Modified Gold Nanoparticles to Overcome the Chemoresistance to Gemcitabine in Mutant p53 Cancer Cells

Modified Gold Nanoparticles to Overcome the Chemoresistance to Gemcitabine in Mutant p53 Cancer Cells

Mutant p53 proteins result from missense mutations in the TP53 gene, the most mutated in human cancer, and have been described to contribute to cancer initiation and progression. Therapeutic strategies for targeting mutant p53 proteins in cancer cells are limited and have proved unsuitable for clini...

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Bibliographic Details
Main Authors: Eduardo García-Garrido, Marco Cordani, Álvaro Somoza
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceutics
Subjects:
mutant p53
nanomedicine
drug delivery
cancer therapy
gold nanoparticles
nucleic acids
Online Access:https://www.mdpi.com/1999-4923/13/12/2067

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