Postnatal - Physiological Research of the Bronchial Receptor System Development on the Isolated Preparation of The Human Trachea In Vitro
Research was done on pharmacological-physiological development of the bronchial receptor system on the smooth muscles of trachea in the newborn children, alive-born and stillborn children. Monitored was the response on: acetylcholine, dopamine, histamine and serotonin in different molar concentrati...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2006-08-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3149 |
| _version_ | 1797260797635723264 |
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| author | Aziz Šukalo Hilmi Islami Ragib Shabani Hilmi Dauti Skender Kutllovci Bashkim Kastrati |
| author_facet | Aziz Šukalo Hilmi Islami Ragib Shabani Hilmi Dauti Skender Kutllovci Bashkim Kastrati |
| author_sort | Aziz Šukalo |
| collection | DOAJ |
| description |
Research was done on pharmacological-physiological development of the bronchial receptor system on the smooth muscles of trachea in the newborn children, alive-born and stillborn children. Monitored was the response on: acetylcholine, dopamine, histamine and serotonin in different molar concentrations 10(-4), 10(-3), 10(-2), 10 mol/dm(-3), micromol/dm(-3)). Research was done on tonus of tracheal smooth muscles of 23 tracheal preparations taken by autopsy after death from different factors. Based on pharmacological-physiological research on the preparations of human isolated trachea it was find out that: acetylcholine stimulation effect is significant (p>0,01) in 38-41 weeks of pregnancy comparing with that in 30-37 weeks of pregnancy (p>0,01), while dopamine stimulation effect is significant (p>0,05) in 30-37 pregnancy weeks comparing with the effect of acetylcholine and dopamine on the still-born infants of the same pregnancy period (p<0,01). Histaminic receptors were developed during intrauterine life after 38 weeks of pregnancy (p>0,025). Serotonin has caused contraction of the bronchial smooth muscles after 30 pregnancy weeks, but response was not significant (p<0,01). This suggests that cholinergic and adrenergic system of the airways in alive newborn infants develops in parallel intrauterine, contrary to other systems which develop in certain extrauterine life phases.
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| first_indexed | 2024-04-24T23:31:02Z |
| format | Article |
| id | doaj.art-cb488cd80d294df1ad8ee290abbc51ec |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:31:02Z |
| publishDate | 2006-08-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-cb488cd80d294df1ad8ee290abbc51ec2024-03-15T14:42:29ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2006-08-016310.17305/bjbms.2006.3149701Postnatal - Physiological Research of the Bronchial Receptor System Development on the Isolated Preparation of The Human Trachea In VitroAziz Šukalo0Hilmi Islami1Ragib Shabani2Hilmi Dauti3Skender Kutllovci4Bashkim Kastrati5Bosnalijek-Pharmaceutical Company - SarajevoInstitute for Pharmacology, Faculty of Medicine, University of PristhinaInstitute for Pathology, Faculty of Medicine, University of PrishtinaInstitute for Anatomy, Faculty of Medicine, University of PrishtinaBosnalijek-Pharmaceutical Company - SarajevoInstitute for Pharmacology, Faculty of Medicine, University of Prishtina Research was done on pharmacological-physiological development of the bronchial receptor system on the smooth muscles of trachea in the newborn children, alive-born and stillborn children. Monitored was the response on: acetylcholine, dopamine, histamine and serotonin in different molar concentrations 10(-4), 10(-3), 10(-2), 10 mol/dm(-3), micromol/dm(-3)). Research was done on tonus of tracheal smooth muscles of 23 tracheal preparations taken by autopsy after death from different factors. Based on pharmacological-physiological research on the preparations of human isolated trachea it was find out that: acetylcholine stimulation effect is significant (p>0,01) in 38-41 weeks of pregnancy comparing with that in 30-37 weeks of pregnancy (p>0,01), while dopamine stimulation effect is significant (p>0,05) in 30-37 pregnancy weeks comparing with the effect of acetylcholine and dopamine on the still-born infants of the same pregnancy period (p<0,01). Histaminic receptors were developed during intrauterine life after 38 weeks of pregnancy (p>0,025). Serotonin has caused contraction of the bronchial smooth muscles after 30 pregnancy weeks, but response was not significant (p<0,01). This suggests that cholinergic and adrenergic system of the airways in alive newborn infants develops in parallel intrauterine, contrary to other systems which develop in certain extrauterine life phases. https://www.bjbms.org/ojs/index.php/bjbms/article/view/3149cholinergicadrenergichistaminergic and serotonergic receptorshuman trachea |
| spellingShingle | Aziz Šukalo Hilmi Islami Ragib Shabani Hilmi Dauti Skender Kutllovci Bashkim Kastrati Postnatal - Physiological Research of the Bronchial Receptor System Development on the Isolated Preparation of The Human Trachea In Vitro Biomolecules & Biomedicine cholinergic adrenergic histaminergic and serotonergic receptors human trachea |
| title | Postnatal - Physiological Research of the Bronchial Receptor System Development on the Isolated Preparation of The Human Trachea In Vitro |
| title_full | Postnatal - Physiological Research of the Bronchial Receptor System Development on the Isolated Preparation of The Human Trachea In Vitro |
| title_fullStr | Postnatal - Physiological Research of the Bronchial Receptor System Development on the Isolated Preparation of The Human Trachea In Vitro |
| title_full_unstemmed | Postnatal - Physiological Research of the Bronchial Receptor System Development on the Isolated Preparation of The Human Trachea In Vitro |
| title_short | Postnatal - Physiological Research of the Bronchial Receptor System Development on the Isolated Preparation of The Human Trachea In Vitro |
| title_sort | postnatal physiological research of the bronchial receptor system development on the isolated preparation of the human trachea in vitro |
| topic | cholinergic adrenergic histaminergic and serotonergic receptors human trachea |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3149 |
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