Dynamic changes of region-specific cortical features and scalp-to-cortex distance: implications for transcranial current stimulation modeling
Abstract Background Transcranial current stimulation in rehabilitation is a fast-growing field featured with computational and biophysical modeling. Cortical features and scalp-to-cortex distance (SCD) are key variables for determining the strength and distribution of the electric field, yet longitu...
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| Format: | Article |
| Language: | English |
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BMC
2021-01-01
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| Series: | Journal of NeuroEngineering and Rehabilitation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12984-020-00764-5 |
| _version_ | 1818419175475904512 |
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| author | Hanna Lu Jing Li Li Zhang Sandra Sau Man Chan Linda Chiu Wa Lam for the Open Access Series of Imaging Studies |
| author_facet | Hanna Lu Jing Li Li Zhang Sandra Sau Man Chan Linda Chiu Wa Lam for the Open Access Series of Imaging Studies |
| author_sort | Hanna Lu |
| collection | DOAJ |
| description | Abstract Background Transcranial current stimulation in rehabilitation is a fast-growing field featured with computational and biophysical modeling. Cortical features and scalp-to-cortex distance (SCD) are key variables for determining the strength and distribution of the electric field, yet longitudinal studies able to capture these dynamic changes are missing. We sought to investigate and quantify the ageing effect on the morphometry and SCD of left primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) in normal ageing adults and mild cognitive impairment (MCI) converters. Methods Baseline, 1-year and 3-year follow-up structural magnetic resonance imaging scans from normal ageing adults (n = 32), and MCI converters (n = 22) were drawn from the Open Access Series of Imaging Studies. We quantified the changes of the cortical features and SCDs of left M1 and DLPFC, including grey matter volume, white matter volume, cortical thickness, and folding. Head model was developed to simulate the impact of SCD on the electric field induced by transcranial current stimulation. Results Pronounced ageing effect was found on the SCD of left DLPFC in MCI converters. The SCD change of left DLPFC from baseline to 3-year follow-up demonstrated better performance to discriminate MCI converters from normal ageing adults than the other morphometric measures. The strength of electric field was consequently decreased with SCD in MCI converters. Conclusion Ageing has a prominent, but differential effect on the region-specific SCD and cortical features in older adults with cognitive impairments. Our findings suggest that SCD, cortical thickness, and folding of the targeted regions could be used as valuable imaging markers when conducting transcranial brain stimulation in individuals with brain atrophy. |
| first_indexed | 2024-12-14T12:34:24Z |
| format | Article |
| id | doaj.art-cb4a8c11de7f44999bc63bbdf3eadfcb |
| institution | Directory Open Access Journal |
| issn | 1743-0003 |
| language | English |
| last_indexed | 2024-12-14T12:34:24Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of NeuroEngineering and Rehabilitation |
| spelling | doaj.art-cb4a8c11de7f44999bc63bbdf3eadfcb2022-12-21T23:01:06ZengBMCJournal of NeuroEngineering and Rehabilitation1743-00032021-01-0118111210.1186/s12984-020-00764-5Dynamic changes of region-specific cortical features and scalp-to-cortex distance: implications for transcranial current stimulation modelingHanna Lu0Jing Li1Li Zhang2Sandra Sau Man Chan3Linda Chiu Wa Lam4for the Open Access Series of Imaging StudiesDepartment of Psychiatry, Multi-Centre, The Chinese University of Hong Kong, Tai Po HospitalDepartment of Psychiatry, Multi-Centre, The Chinese University of Hong Kong, Tai Po HospitalDepartment of Mechanical and Automation Engineering, The Chinese University of Hong KongDepartment of Psychiatry, Multi-Centre, The Chinese University of Hong Kong, Tai Po HospitalDepartment of Psychiatry, Multi-Centre, The Chinese University of Hong Kong, Tai Po HospitalAbstract Background Transcranial current stimulation in rehabilitation is a fast-growing field featured with computational and biophysical modeling. Cortical features and scalp-to-cortex distance (SCD) are key variables for determining the strength and distribution of the electric field, yet longitudinal studies able to capture these dynamic changes are missing. We sought to investigate and quantify the ageing effect on the morphometry and SCD of left primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) in normal ageing adults and mild cognitive impairment (MCI) converters. Methods Baseline, 1-year and 3-year follow-up structural magnetic resonance imaging scans from normal ageing adults (n = 32), and MCI converters (n = 22) were drawn from the Open Access Series of Imaging Studies. We quantified the changes of the cortical features and SCDs of left M1 and DLPFC, including grey matter volume, white matter volume, cortical thickness, and folding. Head model was developed to simulate the impact of SCD on the electric field induced by transcranial current stimulation. Results Pronounced ageing effect was found on the SCD of left DLPFC in MCI converters. The SCD change of left DLPFC from baseline to 3-year follow-up demonstrated better performance to discriminate MCI converters from normal ageing adults than the other morphometric measures. The strength of electric field was consequently decreased with SCD in MCI converters. Conclusion Ageing has a prominent, but differential effect on the region-specific SCD and cortical features in older adults with cognitive impairments. Our findings suggest that SCD, cortical thickness, and folding of the targeted regions could be used as valuable imaging markers when conducting transcranial brain stimulation in individuals with brain atrophy.https://doi.org/10.1186/s12984-020-00764-5Scalp-to-cortex distanceCortical foldingAgeingDLPFCBrain stimulationModeling |
| spellingShingle | Hanna Lu Jing Li Li Zhang Sandra Sau Man Chan Linda Chiu Wa Lam for the Open Access Series of Imaging Studies Dynamic changes of region-specific cortical features and scalp-to-cortex distance: implications for transcranial current stimulation modeling Journal of NeuroEngineering and Rehabilitation Scalp-to-cortex distance Cortical folding Ageing DLPFC Brain stimulation Modeling |
| title | Dynamic changes of region-specific cortical features and scalp-to-cortex distance: implications for transcranial current stimulation modeling |
| title_full | Dynamic changes of region-specific cortical features and scalp-to-cortex distance: implications for transcranial current stimulation modeling |
| title_fullStr | Dynamic changes of region-specific cortical features and scalp-to-cortex distance: implications for transcranial current stimulation modeling |
| title_full_unstemmed | Dynamic changes of region-specific cortical features and scalp-to-cortex distance: implications for transcranial current stimulation modeling |
| title_short | Dynamic changes of region-specific cortical features and scalp-to-cortex distance: implications for transcranial current stimulation modeling |
| title_sort | dynamic changes of region specific cortical features and scalp to cortex distance implications for transcranial current stimulation modeling |
| topic | Scalp-to-cortex distance Cortical folding Ageing DLPFC Brain stimulation Modeling |
| url | https://doi.org/10.1186/s12984-020-00764-5 |
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