Role of the Wnt signaling molecules in the tooth
Wnt signaling plays a central role in many processes during embryonic development and adult homeostasis. At least 19 types of Wnt ligands, receptors, transducers, transcription factors, and antagonists have been identified in mammals. Two distinct Wnt signaling pathways, the canonical signaling path...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-11-01
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| Series: | Japanese Dental Science Review |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1882761616300059 |
| _version_ | 1819078408929280000 |
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| author | Masato Tamura, PhD, DDS Eiji Nemoto, PhD, DDS |
| author_facet | Masato Tamura, PhD, DDS Eiji Nemoto, PhD, DDS |
| author_sort | Masato Tamura, PhD, DDS |
| collection | DOAJ |
| description | Wnt signaling plays a central role in many processes during embryonic development and adult homeostasis. At least 19 types of Wnt ligands, receptors, transducers, transcription factors, and antagonists have been identified in mammals. Two distinct Wnt signaling pathways, the canonical signaling pathway and the noncanonical signaling pathway, have been described. Some Wnt signaling pathway components are expressed in the dental epithelium and mesenchyme during tooth development in humans and mice. Functional studies and experimental analysis of relevant animal models confirm the effects of Wnt signaling pathway on the regulation of developing tooth formation and adult tooth homeostasis. Mutations in some Wnt signaling pathway components have been identified in syndromic and non-syndromic tooth agenesis. This review provides an overview of progress in elucidating the role of Wnt signaling pathway components in the tooth and the resulting possibilities for therapeutic development. |
| first_indexed | 2024-12-21T19:12:38Z |
| format | Article |
| id | doaj.art-cb4eeb8204fe4fd889a4a3f8b24bcb22 |
| institution | Directory Open Access Journal |
| issn | 1882-7616 |
| language | English |
| last_indexed | 2024-12-21T19:12:38Z |
| publishDate | 2016-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj.art-cb4eeb8204fe4fd889a4a3f8b24bcb222022-12-21T18:53:10ZengElsevierJapanese Dental Science Review1882-76162016-11-01524758310.1016/j.jdsr.2016.04.001Role of the Wnt signaling molecules in the toothMasato Tamura, PhD, DDS0Eiji Nemoto, PhD, DDS1Department of Biochemistry and Molecular Biology, Graduate School of Dental Medicine, Hokkaido University, N13, W7, Sapporo, JapanDepartment of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba, Sendai, JapanWnt signaling plays a central role in many processes during embryonic development and adult homeostasis. At least 19 types of Wnt ligands, receptors, transducers, transcription factors, and antagonists have been identified in mammals. Two distinct Wnt signaling pathways, the canonical signaling pathway and the noncanonical signaling pathway, have been described. Some Wnt signaling pathway components are expressed in the dental epithelium and mesenchyme during tooth development in humans and mice. Functional studies and experimental analysis of relevant animal models confirm the effects of Wnt signaling pathway on the regulation of developing tooth formation and adult tooth homeostasis. Mutations in some Wnt signaling pathway components have been identified in syndromic and non-syndromic tooth agenesis. This review provides an overview of progress in elucidating the role of Wnt signaling pathway components in the tooth and the resulting possibilities for therapeutic development.http://www.sciencedirect.com/science/article/pii/S1882761616300059ToothPeriodontal tissueWnt signalingCanonical WntTooth developmentTooth agenesisHypodontiaOligodontia |
| spellingShingle | Masato Tamura, PhD, DDS Eiji Nemoto, PhD, DDS Role of the Wnt signaling molecules in the tooth Japanese Dental Science Review Tooth Periodontal tissue Wnt signaling Canonical Wnt Tooth development Tooth agenesis Hypodontia Oligodontia |
| title | Role of the Wnt signaling molecules in the tooth |
| title_full | Role of the Wnt signaling molecules in the tooth |
| title_fullStr | Role of the Wnt signaling molecules in the tooth |
| title_full_unstemmed | Role of the Wnt signaling molecules in the tooth |
| title_short | Role of the Wnt signaling molecules in the tooth |
| title_sort | role of the wnt signaling molecules in the tooth |
| topic | Tooth Periodontal tissue Wnt signaling Canonical Wnt Tooth development Tooth agenesis Hypodontia Oligodontia |
| url | http://www.sciencedirect.com/science/article/pii/S1882761616300059 |
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