Quinolone Signals Related to Pseudomonas Quinolone Signal-Quorum Sensing Inhibits the Predatory Activity of Bdellovibrio bacteriovorus
Bdellovibrio bacteriovorus is one of the predatory bacteria; therefore, it can act as a novel “living antibiotic,” unlike the current antibiotics. Here the predation of Escherichia coli by B. bacteriovorus was inhibited in the presence of Pseudomonas aeruginosa. This study investigated whether P. ae...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.722579/full |
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| author | Yuki Hoshiko Yoshito Nishiyama Tae Moriya Kiwao Kadokami Luis Esaú López-Jácome Luis Esaú López-Jácome Ryutaro Hirano Rodolfo García-Contreras Toshinari Maeda |
| author_facet | Yuki Hoshiko Yoshito Nishiyama Tae Moriya Kiwao Kadokami Luis Esaú López-Jácome Luis Esaú López-Jácome Ryutaro Hirano Rodolfo García-Contreras Toshinari Maeda |
| author_sort | Yuki Hoshiko |
| collection | DOAJ |
| description | Bdellovibrio bacteriovorus is one of the predatory bacteria; therefore, it can act as a novel “living antibiotic,” unlike the current antibiotics. Here the predation of Escherichia coli by B. bacteriovorus was inhibited in the presence of Pseudomonas aeruginosa. This study investigated whether P. aeruginosa-induced predation inhibition is associated with bacterial quorum sensing (QS). Each las, rhl, or pqs QS mutant in P. aeruginosa was used to check the predatory activity of E. coli cells using B. bacteriovorus. As a result, the predatory activity of B. bacteriovorus increased in a mutant pqs QS system, whereas wild-type PA14 inhibited the predatory activity. Moreover, the addition of 4-hydroxy-2-heptylquinoline (HHQ) or the analog triggered the low predatory activity of B. bacteriovorus and killed B. bacteriovorus cells. Therefore, a defensive action of P. aeruginosa against B. bacteriovorus is activated by the pqs QS system, which produces some quinolone compounds such as HHQ. |
| first_indexed | 2024-12-14T00:34:42Z |
| format | Article |
| id | doaj.art-cb50bc31aa854d3b870a9f4dcff8fccb |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-14T00:34:42Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-cb50bc31aa854d3b870a9f4dcff8fccb2022-12-21T23:24:42ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-09-011210.3389/fmicb.2021.722579722579Quinolone Signals Related to Pseudomonas Quinolone Signal-Quorum Sensing Inhibits the Predatory Activity of Bdellovibrio bacteriovorusYuki Hoshiko0Yoshito Nishiyama1Tae Moriya2Kiwao Kadokami3Luis Esaú López-Jácome4Luis Esaú López-Jácome5Ryutaro Hirano6Rodolfo García-Contreras7Toshinari Maeda8Department of Biological Functions Engineering, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu, JapanDepartment of Biological Functions Engineering, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu, JapanDepartment of Biological Functions Engineering, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu, JapanInstitute of Environmental Science and Technology, The University of Kitakyushu, Kitakyushu, JapanDepartment of Microbiology and Parasitology, Faculty of Medicine, UNAM, Mexico City, MexicoLaboratory of Infectology, National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra, Mexico City, MexicoDepartment of Biological Functions Engineering, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu, JapanDepartment of Microbiology and Parasitology, Faculty of Medicine, UNAM, Mexico City, MexicoDepartment of Biological Functions Engineering, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu, JapanBdellovibrio bacteriovorus is one of the predatory bacteria; therefore, it can act as a novel “living antibiotic,” unlike the current antibiotics. Here the predation of Escherichia coli by B. bacteriovorus was inhibited in the presence of Pseudomonas aeruginosa. This study investigated whether P. aeruginosa-induced predation inhibition is associated with bacterial quorum sensing (QS). Each las, rhl, or pqs QS mutant in P. aeruginosa was used to check the predatory activity of E. coli cells using B. bacteriovorus. As a result, the predatory activity of B. bacteriovorus increased in a mutant pqs QS system, whereas wild-type PA14 inhibited the predatory activity. Moreover, the addition of 4-hydroxy-2-heptylquinoline (HHQ) or the analog triggered the low predatory activity of B. bacteriovorus and killed B. bacteriovorus cells. Therefore, a defensive action of P. aeruginosa against B. bacteriovorus is activated by the pqs QS system, which produces some quinolone compounds such as HHQ.https://www.frontiersin.org/articles/10.3389/fmicb.2021.722579/fullinhibition factorsEscherichia coliquorum sensingPseudomonas quinolone signalPseudomonas aeruginosaBdellovibrio bacteriovorus |
| spellingShingle | Yuki Hoshiko Yoshito Nishiyama Tae Moriya Kiwao Kadokami Luis Esaú López-Jácome Luis Esaú López-Jácome Ryutaro Hirano Rodolfo García-Contreras Toshinari Maeda Quinolone Signals Related to Pseudomonas Quinolone Signal-Quorum Sensing Inhibits the Predatory Activity of Bdellovibrio bacteriovorus Frontiers in Microbiology inhibition factors Escherichia coli quorum sensing Pseudomonas quinolone signal Pseudomonas aeruginosa Bdellovibrio bacteriovorus |
| title | Quinolone Signals Related to Pseudomonas Quinolone Signal-Quorum Sensing Inhibits the Predatory Activity of Bdellovibrio bacteriovorus |
| title_full | Quinolone Signals Related to Pseudomonas Quinolone Signal-Quorum Sensing Inhibits the Predatory Activity of Bdellovibrio bacteriovorus |
| title_fullStr | Quinolone Signals Related to Pseudomonas Quinolone Signal-Quorum Sensing Inhibits the Predatory Activity of Bdellovibrio bacteriovorus |
| title_full_unstemmed | Quinolone Signals Related to Pseudomonas Quinolone Signal-Quorum Sensing Inhibits the Predatory Activity of Bdellovibrio bacteriovorus |
| title_short | Quinolone Signals Related to Pseudomonas Quinolone Signal-Quorum Sensing Inhibits the Predatory Activity of Bdellovibrio bacteriovorus |
| title_sort | quinolone signals related to pseudomonas quinolone signal quorum sensing inhibits the predatory activity of bdellovibrio bacteriovorus |
| topic | inhibition factors Escherichia coli quorum sensing Pseudomonas quinolone signal Pseudomonas aeruginosa Bdellovibrio bacteriovorus |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.722579/full |
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