IL-17A-mediated mitochondrial dysfunction induces pyroptosis in colorectal cancer cells and promotes CD8 + T-cell tumour infiltration

IL-17A-mediated mitochondrial dysfunction induces pyroptosis in colorectal cancer cells and promotes CD8 + T-cell tumour infiltration

Abstract Background Interleukin-17A (IL-17A), a proinflammatory cytokine primarily secreted by Th17 cells, γδT cells and natural killer T (NKT) cells, performs essential roles in the microenvironment of certain inflammation-related tumours by regulating cancer growth and tumour elimination proved in...

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Bibliographic Details
Main Authors: Wen-Qing Feng, Yu-Chen Zhang, Zhuo-Qing Xu, Su-Yue Yu, Jian-ting Huo, Abudumaimaitijiang Tuersun, Min-Hua Zheng, Jing-Kun Zhao, Ya-Ping Zong, Ai-Guo Lu
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Translational Medicine
Subjects:
IL-17A
Colorectal cancer
Mitochondrial dysfunction
Pyroptosis
CD8 + T
Online Access:https://doi.org/10.1186/s12967-023-04187-3

Internet

https://doi.org/10.1186/s12967-023-04187-3

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