Dietary Polyphenols, Berries, and Age-Related Bone Loss: A Review Based on Human, Animal, and Cell Studies
Bone loss during aging has become an increasing public health concern as average life expectancy has increased. One of the most prevalent forms of age-related bone disease today is osteoporosis in which the body slows down bone formation and existing bone is increasingly being resorbed by the body t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-03-01
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| Series: | Antioxidants |
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| Online Access: | http://www.mdpi.com/2076-3921/3/1/144 |
| _version_ | 1797762894184579072 |
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| author | Patrice A. Hubert Sang Gil Lee Sun-Kyeong Lee Ock K. Chun |
| author_facet | Patrice A. Hubert Sang Gil Lee Sun-Kyeong Lee Ock K. Chun |
| author_sort | Patrice A. Hubert |
| collection | DOAJ |
| description | Bone loss during aging has become an increasing public health concern as average life expectancy has increased. One of the most prevalent forms of age-related bone disease today is osteoporosis in which the body slows down bone formation and existing bone is increasingly being resorbed by the body to maintain the calcium balance. Some causes of this bone loss can be attributed to dysregulation of osteoblast and osteoclast activity mediated by increased oxidative stress through the aging process. Due to certain serious adverse effects of the currently available therapeutic agents that limit their efficacy, complementary and alternative medicine (CAM) has garnered interest as a natural means for the prevention of this debilitating disease. Natural antioxidant supplementation, a type of CAM, has been researched to aid in reducing bone loss caused by oxidative stress. Naturally occurring polyphenols, such as anthocyanins rich in berries, are known to have anti-oxidative properties. Several studies have been reviewed to determine the impact polyphenol intake—particularly that of berries—has on bone health. Studies reveal a positive association of high berry intake and higher bone mass, implicating berries as possible inexpensive alternatives in reducing the risk of age related bone loss. |
| first_indexed | 2024-03-12T19:34:54Z |
| format | Article |
| id | doaj.art-cb5655173110498e8129d308a2a7b481 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T19:34:54Z |
| publishDate | 2014-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-cb5655173110498e8129d308a2a7b4812023-08-02T04:18:14ZengMDPI AGAntioxidants2076-39212014-03-013114415810.3390/antiox3010144antiox3010144Dietary Polyphenols, Berries, and Age-Related Bone Loss: A Review Based on Human, Animal, and Cell StudiesPatrice A. Hubert0Sang Gil Lee1Sun-Kyeong Lee2Ock K. Chun3Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269-4017, USADepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269-4017, USACenter on Aging, University of Connecticut Health Center, Farmington, CT 06030-5215, USADepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269-4017, USABone loss during aging has become an increasing public health concern as average life expectancy has increased. One of the most prevalent forms of age-related bone disease today is osteoporosis in which the body slows down bone formation and existing bone is increasingly being resorbed by the body to maintain the calcium balance. Some causes of this bone loss can be attributed to dysregulation of osteoblast and osteoclast activity mediated by increased oxidative stress through the aging process. Due to certain serious adverse effects of the currently available therapeutic agents that limit their efficacy, complementary and alternative medicine (CAM) has garnered interest as a natural means for the prevention of this debilitating disease. Natural antioxidant supplementation, a type of CAM, has been researched to aid in reducing bone loss caused by oxidative stress. Naturally occurring polyphenols, such as anthocyanins rich in berries, are known to have anti-oxidative properties. Several studies have been reviewed to determine the impact polyphenol intake—particularly that of berries—has on bone health. Studies reveal a positive association of high berry intake and higher bone mass, implicating berries as possible inexpensive alternatives in reducing the risk of age related bone loss.http://www.mdpi.com/2076-3921/3/1/144agingbone lossosteoporosisoxidative stressberriespolyphenolsanthocyanins |
| spellingShingle | Patrice A. Hubert Sang Gil Lee Sun-Kyeong Lee Ock K. Chun Dietary Polyphenols, Berries, and Age-Related Bone Loss: A Review Based on Human, Animal, and Cell Studies Antioxidants aging bone loss osteoporosis oxidative stress berries polyphenols anthocyanins |
| title | Dietary Polyphenols, Berries, and Age-Related Bone Loss: A Review Based on Human, Animal, and Cell Studies |
| title_full | Dietary Polyphenols, Berries, and Age-Related Bone Loss: A Review Based on Human, Animal, and Cell Studies |
| title_fullStr | Dietary Polyphenols, Berries, and Age-Related Bone Loss: A Review Based on Human, Animal, and Cell Studies |
| title_full_unstemmed | Dietary Polyphenols, Berries, and Age-Related Bone Loss: A Review Based on Human, Animal, and Cell Studies |
| title_short | Dietary Polyphenols, Berries, and Age-Related Bone Loss: A Review Based on Human, Animal, and Cell Studies |
| title_sort | dietary polyphenols berries and age related bone loss a review based on human animal and cell studies |
| topic | aging bone loss osteoporosis oxidative stress berries polyphenols anthocyanins |
| url | http://www.mdpi.com/2076-3921/3/1/144 |
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