Incorporation of Biologically Active Ingredient Gallic Acid Into Nano-scale Lipid Vesicles
Nano-scale lipid vesicles or liposomes are extremely important lipid particles because of their unique properties and possible incorporation of various biologically active substances into their interior. Therefore, they can be used for numerous biomedical applications. Liposomes have the ability to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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AIDIC Servizi S.r.l.
2023-06-01
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| Series: | Chemical Engineering Transactions |
| Online Access: | https://www.cetjournal.it/index.php/cet/article/view/13409 |
| _version_ | 1827912185253199872 |
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| author | Nika Kucuk Mateja Primozic Zeljko Knez Maja Leitgeb |
| author_facet | Nika Kucuk Mateja Primozic Zeljko Knez Maja Leitgeb |
| author_sort | Nika Kucuk |
| collection | DOAJ |
| description | Nano-scale lipid vesicles or liposomes are extremely important lipid particles because of their unique properties and possible incorporation of various biologically active substances into their interior. Therefore, they can be used for numerous biomedical applications. Liposomes have the ability to protect incorporated bioactive substances, thereby preserving their function. They have a significant advantage over various nanoparticles, as they can bind and transfer hydrophobic, hydrophilic, and amphiphilic compounds.
The aim of the study was the synthesis of liposomes, suitable for the potential encapsulation of active ingredients for pharmaceutical and clinical purposes. Liposomes were prepared using a thin lipid film hydration method with glass beads. The synthesized liposomes were characterized by measuring the zeta potential to determine their stability, polydispersity index, and particle size. Furthermore, the biologically active ingredient gallic acid (GA) was incorporated into the lipid vesicles at different concentrations. The encapsulation efficiency of the active ingredient GA in liposomes and the in vitro release of the encapsulated bioactive component were studied using the dialysis technique. Synthesized nano-scale lipid vesicles were found to be stable, with an average size of 181.5 nm. The highest encapsulation efficiency (98.3%) and the highest percentage of released bioactive substance (38.3%) were obtained at 0.1 mg/mL of GA. GA-incorporated nano-scale lipid vesicles are promising as suitable carriers of bioactive ingredients for various therapeutic purposes. |
| first_indexed | 2024-03-13T02:12:27Z |
| format | Article |
| id | doaj.art-cb5723ffd84b427d9b8ab88d746072f7 |
| institution | Directory Open Access Journal |
| issn | 2283-9216 |
| language | English |
| last_indexed | 2024-03-13T02:12:27Z |
| publishDate | 2023-06-01 |
| publisher | AIDIC Servizi S.r.l. |
| record_format | Article |
| series | Chemical Engineering Transactions |
| spelling | doaj.art-cb5723ffd84b427d9b8ab88d746072f72023-06-30T22:32:04ZengAIDIC Servizi S.r.l.Chemical Engineering Transactions2283-92162023-06-0110010.3303/CET23100087Incorporation of Biologically Active Ingredient Gallic Acid Into Nano-scale Lipid VesiclesNika KucukMateja PrimozicZeljko KnezMaja LeitgebNano-scale lipid vesicles or liposomes are extremely important lipid particles because of their unique properties and possible incorporation of various biologically active substances into their interior. Therefore, they can be used for numerous biomedical applications. Liposomes have the ability to protect incorporated bioactive substances, thereby preserving their function. They have a significant advantage over various nanoparticles, as they can bind and transfer hydrophobic, hydrophilic, and amphiphilic compounds. The aim of the study was the synthesis of liposomes, suitable for the potential encapsulation of active ingredients for pharmaceutical and clinical purposes. Liposomes were prepared using a thin lipid film hydration method with glass beads. The synthesized liposomes were characterized by measuring the zeta potential to determine their stability, polydispersity index, and particle size. Furthermore, the biologically active ingredient gallic acid (GA) was incorporated into the lipid vesicles at different concentrations. The encapsulation efficiency of the active ingredient GA in liposomes and the in vitro release of the encapsulated bioactive component were studied using the dialysis technique. Synthesized nano-scale lipid vesicles were found to be stable, with an average size of 181.5 nm. The highest encapsulation efficiency (98.3%) and the highest percentage of released bioactive substance (38.3%) were obtained at 0.1 mg/mL of GA. GA-incorporated nano-scale lipid vesicles are promising as suitable carriers of bioactive ingredients for various therapeutic purposes.https://www.cetjournal.it/index.php/cet/article/view/13409 |
| spellingShingle | Nika Kucuk Mateja Primozic Zeljko Knez Maja Leitgeb Incorporation of Biologically Active Ingredient Gallic Acid Into Nano-scale Lipid Vesicles Chemical Engineering Transactions |
| title | Incorporation of Biologically Active Ingredient Gallic Acid Into Nano-scale Lipid Vesicles |
| title_full | Incorporation of Biologically Active Ingredient Gallic Acid Into Nano-scale Lipid Vesicles |
| title_fullStr | Incorporation of Biologically Active Ingredient Gallic Acid Into Nano-scale Lipid Vesicles |
| title_full_unstemmed | Incorporation of Biologically Active Ingredient Gallic Acid Into Nano-scale Lipid Vesicles |
| title_short | Incorporation of Biologically Active Ingredient Gallic Acid Into Nano-scale Lipid Vesicles |
| title_sort | incorporation of biologically active ingredient gallic acid into nano scale lipid vesicles |
| url | https://www.cetjournal.it/index.php/cet/article/view/13409 |
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