Gut-brain axis and Alzheimer's disease: Therapeutic interventions and strategies
The effects of the gut microbiome on the brain and the mechanisms of gut-brain communication have been popular research topics for the past few decades. The term gut-brain axis (GBA) evolved to illustrate how the gut and gut microbiota communicate with the brain. The gut-brain axis is an interplay o...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623005157 |
| _version_ | 1797356158934056960 |
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| author | Hetender Singh Chirag Chopra Hemender Singh Vikas Malgotra Atif Khurshid Wani Daljeet Singh Dhanjal Indu Sharma Eugenie Nepovimova Suliman Alomar Reena Singh Varun Sharma Kamil Kuca |
| author_facet | Hetender Singh Chirag Chopra Hemender Singh Vikas Malgotra Atif Khurshid Wani Daljeet Singh Dhanjal Indu Sharma Eugenie Nepovimova Suliman Alomar Reena Singh Varun Sharma Kamil Kuca |
| author_sort | Hetender Singh |
| collection | DOAJ |
| description | The effects of the gut microbiome on the brain and the mechanisms of gut-brain communication have been popular research topics for the past few decades. The term gut-brain axis (GBA) evolved to illustrate how the gut and gut microbiota communicate with the brain. The gut-brain axis is an interplay of the neural, endocrine, immune, and metabolic pathways that help to maintain the brain's homeostasis. Several groups have reported that gut dysbiosis is significantly associated with neuroinflammation, aggregation of amyloid beta, and an increase in oxidative stress during Alzheimer’s disease (AD). Understanding the exact mechanism of how the gut microbiome influences brain function may help develop new therapeutic modalities for AD. This review highlights the functioning of the gut microbiome in AD pathogenesis, the potential beneficial effects of probiotic exopolysaccharides as therapeutic molecules, and the potential benefits of probiotic exopolysaccharides (EPS) as a ray of hope in treating AD. |
| first_indexed | 2024-03-08T14:22:36Z |
| format | Article |
| id | doaj.art-cb57d648f7d845dea03d21ddad88f5e0 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-08T14:22:36Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-cb57d648f7d845dea03d21ddad88f5e02024-01-14T05:37:08ZengElsevierJournal of Functional Foods1756-46462024-01-01112105915Gut-brain axis and Alzheimer's disease: Therapeutic interventions and strategiesHetender Singh0Chirag Chopra1Hemender Singh2Vikas Malgotra3Atif Khurshid Wani4Daljeet Singh Dhanjal5Indu Sharma6Eugenie Nepovimova7Suliman Alomar8Reena Singh9Varun Sharma10Kamil Kuca11School of Biotechnology, University of Jammu, Baba Saheb Ambedkar Road, Jammu Tawi (J&K) 180006, IndiaSchool of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaSchool of Biotechnology, Shri Mata Vaishno Devi University, Kakryal, Katra 182320, Jammu and Kashmir, India; Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, IndiaMaharishi Markandeshwar Institute of Medical Sciences and Research, Ambala-Yamunanagar Highway, Mullana – Ambala, 133-207 Haryana, IndiaSchool of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaSchool of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, IndiaPopulation Geneticist, Genetic Heritage Group, New York University, Abu Dhabi, PO Box 129188, Saadiyat Island, Abu Dhabi, United Arab EmiratesDepartment of Chemistry, Faculty of Science, University of Hradec Králové, Hradec Králové 50 003, Czech Republic; Clinic of Neurology, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech RepublicZoology Department, College of Science, King Saud University, Saudi ArabiaSchool of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, India; Corresponding authors at: Biomedical Research Center, University Hospital Hradec Kralove, 50005 Hradec Kralove, Czech Republic (K. Kuca).NMC Genetics India Pvt. Ltd, 221-223, Vipul Agora, Mehrauli-Gurgaon Rd, Gurugram, Haryana 122001, India; Corresponding authors at: Biomedical Research Center, University Hospital Hradec Kralove, 50005 Hradec Kralove, Czech Republic (K. Kuca).Department of Chemistry, Faculty of Science, University of Hradec Králové, Hradec Králové 50 003, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, 50005 Hradec Kralove, Czech Republic; Corresponding authors at: Biomedical Research Center, University Hospital Hradec Kralove, 50005 Hradec Kralove, Czech Republic (K. Kuca).The effects of the gut microbiome on the brain and the mechanisms of gut-brain communication have been popular research topics for the past few decades. The term gut-brain axis (GBA) evolved to illustrate how the gut and gut microbiota communicate with the brain. The gut-brain axis is an interplay of the neural, endocrine, immune, and metabolic pathways that help to maintain the brain's homeostasis. Several groups have reported that gut dysbiosis is significantly associated with neuroinflammation, aggregation of amyloid beta, and an increase in oxidative stress during Alzheimer’s disease (AD). Understanding the exact mechanism of how the gut microbiome influences brain function may help develop new therapeutic modalities for AD. This review highlights the functioning of the gut microbiome in AD pathogenesis, the potential beneficial effects of probiotic exopolysaccharides as therapeutic molecules, and the potential benefits of probiotic exopolysaccharides (EPS) as a ray of hope in treating AD.http://www.sciencedirect.com/science/article/pii/S1756464623005157Alzheimer’s diseaseExopolysaccharideNeurological disordersProbioticsGut-brain axisGut microbiome |
| spellingShingle | Hetender Singh Chirag Chopra Hemender Singh Vikas Malgotra Atif Khurshid Wani Daljeet Singh Dhanjal Indu Sharma Eugenie Nepovimova Suliman Alomar Reena Singh Varun Sharma Kamil Kuca Gut-brain axis and Alzheimer's disease: Therapeutic interventions and strategies Journal of Functional Foods Alzheimer’s disease Exopolysaccharide Neurological disorders Probiotics Gut-brain axis Gut microbiome |
| title | Gut-brain axis and Alzheimer's disease: Therapeutic interventions and strategies |
| title_full | Gut-brain axis and Alzheimer's disease: Therapeutic interventions and strategies |
| title_fullStr | Gut-brain axis and Alzheimer's disease: Therapeutic interventions and strategies |
| title_full_unstemmed | Gut-brain axis and Alzheimer's disease: Therapeutic interventions and strategies |
| title_short | Gut-brain axis and Alzheimer's disease: Therapeutic interventions and strategies |
| title_sort | gut brain axis and alzheimer s disease therapeutic interventions and strategies |
| topic | Alzheimer’s disease Exopolysaccharide Neurological disorders Probiotics Gut-brain axis Gut microbiome |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623005157 |
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