Purinergic Regulation of Endothelial Barrier Function
Increased vascular permeability is a hallmark of several cardiovascular anomalies, including ischaemia/reperfusion injury and inflammation. During both ischaemia/reperfusion and inflammation, massive amounts of various nucleotides, particularly adenosine 5′-triphosphate (ATP) and adenosine, are rele...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/3/1207 |
| _version_ | 1797407131713929216 |
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| author | Muhammad Aslam Dursun Gündüz Christian Troidl Jacqueline Heger Christian W. Hamm Rainer Schulz |
| author_facet | Muhammad Aslam Dursun Gündüz Christian Troidl Jacqueline Heger Christian W. Hamm Rainer Schulz |
| author_sort | Muhammad Aslam |
| collection | DOAJ |
| description | Increased vascular permeability is a hallmark of several cardiovascular anomalies, including ischaemia/reperfusion injury and inflammation. During both ischaemia/reperfusion and inflammation, massive amounts of various nucleotides, particularly adenosine 5′-triphosphate (ATP) and adenosine, are released that can induce a plethora of signalling pathways via activation of several purinergic receptors and may affect endothelial barrier properties. The nature of the effects on endothelial barrier function may depend on the prevalence and type of purinergic receptors activated in a particular tissue. In this review, we discuss the influence of the activation of various purinergic receptors and downstream signalling pathways on vascular permeability during pathological conditions. |
| first_indexed | 2024-03-09T03:36:50Z |
| format | Article |
| id | doaj.art-cb58760676f34cbea3969fc61e36b581 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T03:36:50Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-cb58760676f34cbea3969fc61e36b5812023-12-03T14:47:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-01223120710.3390/ijms22031207Purinergic Regulation of Endothelial Barrier FunctionMuhammad Aslam0Dursun Gündüz1Christian Troidl2Jacqueline Heger3Christian W. Hamm4Rainer Schulz5Experimental Cardiology, Department of Internal Medicine I, Justus Liebig University, Aulweg 129, 35392 Giessen, GermanyExperimental Cardiology, Department of Internal Medicine I, Justus Liebig University, Aulweg 129, 35392 Giessen, GermanyExperimental Cardiology, Department of Internal Medicine I, Justus Liebig University, Aulweg 129, 35392 Giessen, GermanyInstitute of Physiology, Justus Liebig University, 35392 Giessen, GermanyExperimental Cardiology, Department of Internal Medicine I, Justus Liebig University, Aulweg 129, 35392 Giessen, GermanyInstitute of Physiology, Justus Liebig University, 35392 Giessen, GermanyIncreased vascular permeability is a hallmark of several cardiovascular anomalies, including ischaemia/reperfusion injury and inflammation. During both ischaemia/reperfusion and inflammation, massive amounts of various nucleotides, particularly adenosine 5′-triphosphate (ATP) and adenosine, are released that can induce a plethora of signalling pathways via activation of several purinergic receptors and may affect endothelial barrier properties. The nature of the effects on endothelial barrier function may depend on the prevalence and type of purinergic receptors activated in a particular tissue. In this review, we discuss the influence of the activation of various purinergic receptors and downstream signalling pathways on vascular permeability during pathological conditions.https://www.mdpi.com/1422-0067/22/3/1207Rac1RhoAperipheral actinadenosineATPADP |
| spellingShingle | Muhammad Aslam Dursun Gündüz Christian Troidl Jacqueline Heger Christian W. Hamm Rainer Schulz Purinergic Regulation of Endothelial Barrier Function International Journal of Molecular Sciences Rac1 RhoA peripheral actin adenosine ATP ADP |
| title | Purinergic Regulation of Endothelial Barrier Function |
| title_full | Purinergic Regulation of Endothelial Barrier Function |
| title_fullStr | Purinergic Regulation of Endothelial Barrier Function |
| title_full_unstemmed | Purinergic Regulation of Endothelial Barrier Function |
| title_short | Purinergic Regulation of Endothelial Barrier Function |
| title_sort | purinergic regulation of endothelial barrier function |
| topic | Rac1 RhoA peripheral actin adenosine ATP ADP |
| url | https://www.mdpi.com/1422-0067/22/3/1207 |
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