Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues?
Grazia Lazzari,1 Giuseppe Buono,2 Benedetto Zannino,2 Giovanni Silvano1 1Radiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, 74100, Italy; 2Medical Oncology Unit, San Rocco Hospital, Sessa Aurunca, Caserta, 81037, ItalyCorrespondence: Grazia LazzariRadiation Oncology Unit, San Giuseppe...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-05-01
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| Series: | Breast Cancer: Targets and Therapy |
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| Online Access: | https://www.dovepress.com/breast-cancer-adjuvant-radiotherapy-in-brca12-tp53-atm-genes-mutations-peer-reviewed-fulltext-article-BCTT |
| _version_ | 1824013731552559104 |
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| author | Lazzari G Buono G Zannino B Silvano G |
| author_facet | Lazzari G Buono G Zannino B Silvano G |
| author_sort | Lazzari G |
| collection | DOAJ |
| description | Grazia Lazzari,1 Giuseppe Buono,2 Benedetto Zannino,2 Giovanni Silvano1 1Radiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, 74100, Italy; 2Medical Oncology Unit, San Rocco Hospital, Sessa Aurunca, Caserta, 81037, ItalyCorrespondence: Grazia LazzariRadiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, 74100, ItalyEmail lazzarigrazia@gmail.comAbstract: BRCA1, BRCA2, TP53 and ATM gene mutations are the most studied tumour suppressor genes (TSGs) influencing the loco-regional approach to breast cancer (BC). Due to altered radio sensitivity of mutated cancer cells, mastectomy has always been advised in most patients with BC linked to TSGs mutations in order to avoid or minimize the use of adjuvant radiotherapy (ART). Whether ART is safe or not in these carriers is still debated. As a result, this issue has been widely discussed in the recent ASTRO and ASCO papers, yielding important and useful recommendations on the use of ART according to the mutational status. In this review, we have highlighted the impact of these mutations on local control, toxicities, second tumors, and contralateral breast cancers (CBCs) after ART to solve remaining doubts and encourage the safe use of ART when indicated.Keywords: radiation, radiosensitivity, tumor suppressor genes |
| first_indexed | 2024-12-18T22:05:13Z |
| format | Article |
| id | doaj.art-cb58ab0776f14abcbf70ba335c8c3fa1 |
| institution | Directory Open Access Journal |
| issn | 1179-1314 |
| language | English |
| last_indexed | 2024-12-18T22:05:13Z |
| publishDate | 2021-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Breast Cancer: Targets and Therapy |
| spelling | doaj.art-cb58ab0776f14abcbf70ba335c8c3fa12022-12-21T20:50:10ZengDove Medical PressBreast Cancer: Targets and Therapy1179-13142021-05-01Volume 1329931064735Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues?Lazzari GBuono GZannino BSilvano GGrazia Lazzari,1 Giuseppe Buono,2 Benedetto Zannino,2 Giovanni Silvano1 1Radiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, 74100, Italy; 2Medical Oncology Unit, San Rocco Hospital, Sessa Aurunca, Caserta, 81037, ItalyCorrespondence: Grazia LazzariRadiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, 74100, ItalyEmail lazzarigrazia@gmail.comAbstract: BRCA1, BRCA2, TP53 and ATM gene mutations are the most studied tumour suppressor genes (TSGs) influencing the loco-regional approach to breast cancer (BC). Due to altered radio sensitivity of mutated cancer cells, mastectomy has always been advised in most patients with BC linked to TSGs mutations in order to avoid or minimize the use of adjuvant radiotherapy (ART). Whether ART is safe or not in these carriers is still debated. As a result, this issue has been widely discussed in the recent ASTRO and ASCO papers, yielding important and useful recommendations on the use of ART according to the mutational status. In this review, we have highlighted the impact of these mutations on local control, toxicities, second tumors, and contralateral breast cancers (CBCs) after ART to solve remaining doubts and encourage the safe use of ART when indicated.Keywords: radiation, radiosensitivity, tumor suppressor geneshttps://www.dovepress.com/breast-cancer-adjuvant-radiotherapy-in-brca12-tp53-atm-genes-mutations-peer-reviewed-fulltext-article-BCTTradiationradiosensitivitytumor suppressor genes |
| spellingShingle | Lazzari G Buono G Zannino B Silvano G Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues? Breast Cancer: Targets and Therapy radiation radiosensitivity tumor suppressor genes |
| title | Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues? |
| title_full | Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues? |
| title_fullStr | Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues? |
| title_full_unstemmed | Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues? |
| title_short | Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues? |
| title_sort | breast cancer adjuvant radiotherapy in brca1 2 tp53 atm genes mutations are there solved issues |
| topic | radiation radiosensitivity tumor suppressor genes |
| url | https://www.dovepress.com/breast-cancer-adjuvant-radiotherapy-in-brca12-tp53-atm-genes-mutations-peer-reviewed-fulltext-article-BCTT |
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