2′-Fucosyllactose Is Well Tolerated in a 100% Whey, Partially Hydrolyzed Infant Formula With : A Randomized Controlled Trial
Human milk oligosaccharides are important components of breast milk. We evaluated feeding tolerance of the human milk oligosaccharide 2′-fucosyllactose (2′FL) in a 100% whey, partially hydrolyzed infant formula with the probiotic Bifidobacterium animalis ssp lactis strain Bb12 ( B lactis ; Test) as...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-03-01
|
| Series: | Global Pediatric Health |
| Online Access: | https://doi.org/10.1177/2333794X19833995 |
| _version_ | 1818488169444671488 |
|---|---|
| author | Heidi M. Storm MS, RD Julie Shepard MD Laura M. Czerkies MS, RD Brian Kineman PhD Sarah S. Cohen MS, PhD Heidi Reichert MA Ryan Carvalho MD |
| author_facet | Heidi M. Storm MS, RD Julie Shepard MD Laura M. Czerkies MS, RD Brian Kineman PhD Sarah S. Cohen MS, PhD Heidi Reichert MA Ryan Carvalho MD |
| author_sort | Heidi M. Storm MS, RD |
| collection | DOAJ |
| description | Human milk oligosaccharides are important components of breast milk. We evaluated feeding tolerance of the human milk oligosaccharide 2′-fucosyllactose (2′FL) in a 100% whey, partially hydrolyzed infant formula with the probiotic Bifidobacterium animalis ssp lactis strain Bb12 ( B lactis ; Test) as compared with the same formula without 2′FL (Control) in a randomized controlled trial of healthy infants enrolled at 2 weeks of age (±5 days). After 6 weeks of feeding the assigned formula, the primary outcome of tolerance was assessed using the Infant Gastrointestinal Symptom Questionnaire. Stooling, vomiting, spit-up, crying, and fussing were compared between groups. Seventy-nine infants were enrolled and 63 completed the study per protocol (30 Test, 33 Control). Infant Gastrointestinal Symptom Questionnaire scores were similar between groups (Test 20.9 ± 4.8, Control 20.7 ± 4.3, P = .82). Partially hydrolyzed infant formula with 2′FL and B lactis is tolerated well, as confirmed by a validated multi-symptom index. |
| first_indexed | 2024-12-10T16:47:38Z |
| format | Article |
| id | doaj.art-cb59c831ec744f7b9862fb7874645bba |
| institution | Directory Open Access Journal |
| issn | 2333-794X |
| language | English |
| last_indexed | 2024-12-10T16:47:38Z |
| publishDate | 2019-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Global Pediatric Health |
| spelling | doaj.art-cb59c831ec744f7b9862fb7874645bba2022-12-22T01:41:01ZengSAGE PublishingGlobal Pediatric Health2333-794X2019-03-01610.1177/2333794X198339952′-Fucosyllactose Is Well Tolerated in a 100% Whey, Partially Hydrolyzed Infant Formula With : A Randomized Controlled TrialHeidi M. Storm MS, RD0Julie Shepard MD1Laura M. Czerkies MS, RD2Brian Kineman PhD3Sarah S. Cohen MS, PhD4Heidi Reichert MA5Ryan Carvalho MD6Nestlé Nutrition, Florham Park, NJ, USAOhio Pediatric Research Association, Inc, Dayton, OH, USANestlé Nutrition, Florham Park, NJ, USANestlé Nutrition, Florham Park, NJ, USAEpidStat Institute, Ann Arbor, MI, USAEpidStat Institute, Ann Arbor, MI, USANestlé Nutrition, Florham Park, NJ, USAHuman milk oligosaccharides are important components of breast milk. We evaluated feeding tolerance of the human milk oligosaccharide 2′-fucosyllactose (2′FL) in a 100% whey, partially hydrolyzed infant formula with the probiotic Bifidobacterium animalis ssp lactis strain Bb12 ( B lactis ; Test) as compared with the same formula without 2′FL (Control) in a randomized controlled trial of healthy infants enrolled at 2 weeks of age (±5 days). After 6 weeks of feeding the assigned formula, the primary outcome of tolerance was assessed using the Infant Gastrointestinal Symptom Questionnaire. Stooling, vomiting, spit-up, crying, and fussing were compared between groups. Seventy-nine infants were enrolled and 63 completed the study per protocol (30 Test, 33 Control). Infant Gastrointestinal Symptom Questionnaire scores were similar between groups (Test 20.9 ± 4.8, Control 20.7 ± 4.3, P = .82). Partially hydrolyzed infant formula with 2′FL and B lactis is tolerated well, as confirmed by a validated multi-symptom index.https://doi.org/10.1177/2333794X19833995 |
| spellingShingle | Heidi M. Storm MS, RD Julie Shepard MD Laura M. Czerkies MS, RD Brian Kineman PhD Sarah S. Cohen MS, PhD Heidi Reichert MA Ryan Carvalho MD 2′-Fucosyllactose Is Well Tolerated in a 100% Whey, Partially Hydrolyzed Infant Formula With : A Randomized Controlled Trial Global Pediatric Health |
| title | 2′-Fucosyllactose Is Well Tolerated in a 100% Whey, Partially Hydrolyzed Infant Formula With : A Randomized Controlled Trial |
| title_full | 2′-Fucosyllactose Is Well Tolerated in a 100% Whey, Partially Hydrolyzed Infant Formula With : A Randomized Controlled Trial |
| title_fullStr | 2′-Fucosyllactose Is Well Tolerated in a 100% Whey, Partially Hydrolyzed Infant Formula With : A Randomized Controlled Trial |
| title_full_unstemmed | 2′-Fucosyllactose Is Well Tolerated in a 100% Whey, Partially Hydrolyzed Infant Formula With : A Randomized Controlled Trial |
| title_short | 2′-Fucosyllactose Is Well Tolerated in a 100% Whey, Partially Hydrolyzed Infant Formula With : A Randomized Controlled Trial |
| title_sort | 2 fucosyllactose is well tolerated in a 100 whey partially hydrolyzed infant formula with a randomized controlled trial |
| url | https://doi.org/10.1177/2333794X19833995 |
| work_keys_str_mv | AT heidimstormmsrd 2fucosyllactoseiswelltoleratedina100wheypartiallyhydrolyzedinfantformulawitharandomizedcontrolledtrial AT julieshepardmd 2fucosyllactoseiswelltoleratedina100wheypartiallyhydrolyzedinfantformulawitharandomizedcontrolledtrial AT lauramczerkiesmsrd 2fucosyllactoseiswelltoleratedina100wheypartiallyhydrolyzedinfantformulawitharandomizedcontrolledtrial AT briankinemanphd 2fucosyllactoseiswelltoleratedina100wheypartiallyhydrolyzedinfantformulawitharandomizedcontrolledtrial AT sarahscohenmsphd 2fucosyllactoseiswelltoleratedina100wheypartiallyhydrolyzedinfantformulawitharandomizedcontrolledtrial AT heidireichertma 2fucosyllactoseiswelltoleratedina100wheypartiallyhydrolyzedinfantformulawitharandomizedcontrolledtrial AT ryancarvalhomd 2fucosyllactoseiswelltoleratedina100wheypartiallyhydrolyzedinfantformulawitharandomizedcontrolledtrial |