Germline MLH1, MSH2 and MSH6 variants in Brazilian patients with colorectal cancer and clinical features suggestive of Lynch Syndrome

Germline MLH1, MSH2 and MSH6 variants in Brazilian patients with colorectal cancer and clinical features suggestive of Lynch Syndrome

Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by germline mutations in one of the major genes involved in mismatch repair (MMR): MLH1, MSH2, MSH6 and more rarely, PMS2. Recently, germline deletions in EPCAM have been also associated to the syndrome. Mo...

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Bibliographic Details
Main Authors: Nayê Balzan Schneider, Tatiane Pastor, André Escremim de Paula, Maria Isabel Achatz, Ândrea Ribeiro dos Santos, Fernanda Sales Luiz Vianna, Clévia Rosset, Manuela Pinheiro, Patricia Ashton‐Prolla, Miguel Ângelo Martins Moreira, Edenir Inêz Palmero, Brazilian Lynch Syndrome Study Group
Format: Article
Language:English
Published: Wiley 2018-05-01
Series:Cancer Medicine
Subjects:
Colorectal cancer
Lynch syndrome
MMR genes
Online Access:https://doi.org/10.1002/cam4.1316

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