Analysis of the relapse of imported Plasmodium vivax and Plasmodium ovale in five provinces of China
Abstract Background The global battle against malaria is facing formidable challenges, particularly in controlling Plasmodium vivax and Plasmodium ovale, whose cases have not been reduced as effectively as Plasmodium falciparum because of their relapse. This study investigates the current situation...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-07-01
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| Series: | Malaria Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12936-023-04642-y |
| _version_ | 1797779077860425728 |
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| author | Hui Yan Shujiao Wei Yuan Sui Shenning Lu Weiwei Zhang Xiangyang Feng Ying Liu Tao Zhang Wei Ruan Jing Xia Wen Lin Benedikt Ley Sarah Auburn Shizhu Li Jun Li Duoquan Wang |
| author_facet | Hui Yan Shujiao Wei Yuan Sui Shenning Lu Weiwei Zhang Xiangyang Feng Ying Liu Tao Zhang Wei Ruan Jing Xia Wen Lin Benedikt Ley Sarah Auburn Shizhu Li Jun Li Duoquan Wang |
| author_sort | Hui Yan |
| collection | DOAJ |
| description | Abstract Background The global battle against malaria is facing formidable challenges, particularly in controlling Plasmodium vivax and Plasmodium ovale, whose cases have not been reduced as effectively as Plasmodium falciparum because of their relapse. This study investigates the current situation and underlying factors contributing to relapse or recrudescence of imported cases of P. vivax and P. ovale, and seeks to provide a reference for reducing relapse or recrudescence in malaria-free areas and offers a scientific basis for designing strategies to prevent imported re-transmission. Methods This study analysed imported P. vivax and P. ovale in Anhui, Zhejiang, Henan, Hubei, and Guangxi provinces during 2014–2021 by retrospective analysis. A case–control study was conducted on patients who experienced relapse or recrudescence. Results From 2014 to 2021, 306 cases of P.vivax and 896 cases of P.ovale were included in the study, while 75 cases had relapse or recrudescence, including 49 cases of P. ovale (65.33%) and 26 cases of P. vivax (34.67%). Within less than 5 weeks after returning to the country, 122 cases of P. vivax (39.87%, 122/306) and 265 cases of P. ovale (29.58%, 265/896) occurred. Within less than 53 weeks, the ratio of P. vivax was 94.77% (290/306), and that of P. ovale was 89.96% (806/896). Among the cases experiencing relapse or recrudescence, only 1 case of P. vivax (1/26 3.85%) and 3 cases of P. ovale (3/49 6.12%) occurred within less than 5 weeks after the first onset, whereas 21 cases of P. vivax (21/26 80.77%) and 42 cases of P. ovale (42/49 85.71%) occurred within less than 53 weeks after the first onset. The difference in relapse or recrudescence due to different drugs and medication regimens and medical activities at various levels of medical institutions was statistically significant. Conclusion In areas where malaria has been eliminated, routine health screening in a scientific time frame for people returning from at-risk areas can effectively improve the efficiency of preventing re-transmission, thereby reducing prevention costs and disease burden. Preventing patients from self-treating and strengthening medication regulations in health facilities are key measures to reduce relapse or recrudescence. |
| first_indexed | 2024-03-12T23:25:33Z |
| format | Article |
| id | doaj.art-cb5a88b08f654ab488b0db30a5bb3e24 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-03-12T23:25:33Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-cb5a88b08f654ab488b0db30a5bb3e242023-07-16T11:10:17ZengBMCMalaria Journal1475-28752023-07-0122111110.1186/s12936-023-04642-yAnalysis of the relapse of imported Plasmodium vivax and Plasmodium ovale in five provinces of ChinaHui Yan0Shujiao Wei1Yuan Sui2Shenning Lu3Weiwei Zhang4Xiangyang Feng5Ying Liu6Tao Zhang7Wei Ruan8Jing Xia9Wen Lin10Benedikt Ley11Sarah Auburn12Shizhu Li13Jun Li14Duoquan Wang15Guangxi Zhuang Autonomous Region Center for Disease Control and PreventionGuangxi Zhuang Autonomous Region Center for Disease Control and PreventionBrown School, Washington UniversityNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); NHC Key Laboratory of Parasite and Vector Biology (National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention)Guangxi Zhuang Autonomous Region Center for Disease Control and PreventionGuangxi Zhuang Autonomous Region Center for Disease Control and PreventionHenan Provincial Center for Disease Control and PreventionAnhui Provincial Center for Disease Control and PreventionZhejiang Provincial Center for Disease Control and PreventionHubei Provincial Center for Disease Control and PreventionHubei Provincial Center for Disease Control and PreventionGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin UniversityGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin UniversityChinese Center for Disease Control and Prevention, National Institute of Parasitic Diseases, Chinese Center for Tropical Diseases Research, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Key Laboratory of Parasite and Vector Biology, Ministry of Health, School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of MedicineGuangxi Zhuang Autonomous Region Center for Disease Control and PreventionChinese Center for Disease Control and Prevention, National Institute of Parasitic Diseases, Chinese Center for Tropical Diseases Research, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Key Laboratory of Parasite and Vector Biology, Ministry of Health, School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of MedicineAbstract Background The global battle against malaria is facing formidable challenges, particularly in controlling Plasmodium vivax and Plasmodium ovale, whose cases have not been reduced as effectively as Plasmodium falciparum because of their relapse. This study investigates the current situation and underlying factors contributing to relapse or recrudescence of imported cases of P. vivax and P. ovale, and seeks to provide a reference for reducing relapse or recrudescence in malaria-free areas and offers a scientific basis for designing strategies to prevent imported re-transmission. Methods This study analysed imported P. vivax and P. ovale in Anhui, Zhejiang, Henan, Hubei, and Guangxi provinces during 2014–2021 by retrospective analysis. A case–control study was conducted on patients who experienced relapse or recrudescence. Results From 2014 to 2021, 306 cases of P.vivax and 896 cases of P.ovale were included in the study, while 75 cases had relapse or recrudescence, including 49 cases of P. ovale (65.33%) and 26 cases of P. vivax (34.67%). Within less than 5 weeks after returning to the country, 122 cases of P. vivax (39.87%, 122/306) and 265 cases of P. ovale (29.58%, 265/896) occurred. Within less than 53 weeks, the ratio of P. vivax was 94.77% (290/306), and that of P. ovale was 89.96% (806/896). Among the cases experiencing relapse or recrudescence, only 1 case of P. vivax (1/26 3.85%) and 3 cases of P. ovale (3/49 6.12%) occurred within less than 5 weeks after the first onset, whereas 21 cases of P. vivax (21/26 80.77%) and 42 cases of P. ovale (42/49 85.71%) occurred within less than 53 weeks after the first onset. The difference in relapse or recrudescence due to different drugs and medication regimens and medical activities at various levels of medical institutions was statistically significant. Conclusion In areas where malaria has been eliminated, routine health screening in a scientific time frame for people returning from at-risk areas can effectively improve the efficiency of preventing re-transmission, thereby reducing prevention costs and disease burden. Preventing patients from self-treating and strengthening medication regulations in health facilities are key measures to reduce relapse or recrudescence.https://doi.org/10.1186/s12936-023-04642-yImportedPlasmodium vivaxPlasmodium ovaleRelapse or recrudescenceIncubationPrimaquine |
| spellingShingle | Hui Yan Shujiao Wei Yuan Sui Shenning Lu Weiwei Zhang Xiangyang Feng Ying Liu Tao Zhang Wei Ruan Jing Xia Wen Lin Benedikt Ley Sarah Auburn Shizhu Li Jun Li Duoquan Wang Analysis of the relapse of imported Plasmodium vivax and Plasmodium ovale in five provinces of China Malaria Journal Imported Plasmodium vivax Plasmodium ovale Relapse or recrudescence Incubation Primaquine |
| title | Analysis of the relapse of imported Plasmodium vivax and Plasmodium ovale in five provinces of China |
| title_full | Analysis of the relapse of imported Plasmodium vivax and Plasmodium ovale in five provinces of China |
| title_fullStr | Analysis of the relapse of imported Plasmodium vivax and Plasmodium ovale in five provinces of China |
| title_full_unstemmed | Analysis of the relapse of imported Plasmodium vivax and Plasmodium ovale in five provinces of China |
| title_short | Analysis of the relapse of imported Plasmodium vivax and Plasmodium ovale in five provinces of China |
| title_sort | analysis of the relapse of imported plasmodium vivax and plasmodium ovale in five provinces of china |
| topic | Imported Plasmodium vivax Plasmodium ovale Relapse or recrudescence Incubation Primaquine |
| url | https://doi.org/10.1186/s12936-023-04642-y |
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