Exposure to polychlorinated biphenyls (PCBs) affects the histology and antioxidant capability of the clam Cyclina sinensis
Polychlorinated biphenyls (PCBs) are environmentally persistent and highly toxic organochlorine compounds that may cause toxic effects on aquatic animals. In this study we assess the toxic effect of PCBs on a bivalve used in aquaculture, the clam Cyclina sinensis. To this end, individuals of C. sine...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Marine Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmars.2023.1076870/full |
| _version_ | 1811176978827444224 |
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| author | Meimei Liu Meimei Liu Sishao Fan Sishao Fan Zhichao Rong Zhichao Rong Hao Qiu Hao Qiu Susu Yan Susu Yan Hongwei Ni Hongwei Ni Zhiguo Dong Zhiguo Dong Zhiguo Dong |
| author_facet | Meimei Liu Meimei Liu Sishao Fan Sishao Fan Zhichao Rong Zhichao Rong Hao Qiu Hao Qiu Susu Yan Susu Yan Hongwei Ni Hongwei Ni Zhiguo Dong Zhiguo Dong Zhiguo Dong |
| author_sort | Meimei Liu |
| collection | DOAJ |
| description | Polychlorinated biphenyls (PCBs) are environmentally persistent and highly toxic organochlorine compounds that may cause toxic effects on aquatic animals. In this study we assess the toxic effect of PCBs on a bivalve used in aquaculture, the clam Cyclina sinensis. To this end, individuals of C. sinensis were exposed for 72 h at two PCB concentrations (1 ng/L and 10 ng/L) and control (absence of PCBs). At the end of the exposure, the hemolymph, hepatopancreas, and gills samples of C. sinensis were harvested for analysis of the enzyme activity and histology. The results showed that acute PCBs exposure decreased the survival rate of C. sinensis compared to the control. Acute PCBs exposure up-regulated the enzymatic activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) and the content of malondialdehyde (MDA) in the hemolymph of C. sinensis, while down-regulated the non-specific enzymatic activity of alkaline phosphatase (AKP). For the hepatopancreas, 1 ng/L PCBs exposure up-regulated the enzymatic activity of SOD while down-regulated the enzymatic activity of CAT of C. sinensis. In the gill, the enzymatic activity of CAT decreased significantly and the MDA content increased of C. sinensis after 10 ng/L PCBs exposure. Moreover, histological observations showed that acute exposure to PCBs caused loss of gill filaments and lateral cilia and shortening of their length, in the studied organism. The present study will provide valuable reference data for marine shellfish aquaculture and toxicology research. |
| first_indexed | 2024-04-10T20:01:52Z |
| format | Article |
| id | doaj.art-cb5ac9b008ae4b7cbc241f75c8477c33 |
| institution | Directory Open Access Journal |
| issn | 2296-7745 |
| language | English |
| last_indexed | 2024-04-10T20:01:52Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Marine Science |
| spelling | doaj.art-cb5ac9b008ae4b7cbc241f75c8477c332023-01-27T05:54:13ZengFrontiers Media S.A.Frontiers in Marine Science2296-77452023-01-011010.3389/fmars.2023.10768701076870Exposure to polychlorinated biphenyls (PCBs) affects the histology and antioxidant capability of the clam Cyclina sinensisMeimei Liu0Meimei Liu1Sishao Fan2Sishao Fan3Zhichao Rong4Zhichao Rong5Hao Qiu6Hao Qiu7Susu Yan8Susu Yan9Hongwei Ni10Hongwei Ni11Zhiguo Dong12Zhiguo Dong13Zhiguo Dong14Jiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Ocean University, Lianyungang, ChinaCo-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Institute of Marine Resources Development, Lianyungang, ChinaJiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Ocean University, Lianyungang, ChinaCo-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Institute of Marine Resources Development, Lianyungang, ChinaJiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Ocean University, Lianyungang, ChinaCo-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Institute of Marine Resources Development, Lianyungang, ChinaJiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Ocean University, Lianyungang, ChinaCo-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Institute of Marine Resources Development, Lianyungang, ChinaJiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Ocean University, Lianyungang, ChinaCo-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Institute of Marine Resources Development, Lianyungang, ChinaJiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Ocean University, Lianyungang, ChinaCo-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Institute of Marine Resources Development, Lianyungang, ChinaJiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Ocean University, Lianyungang, ChinaCo-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Institute of Marine Resources Development, Lianyungang, ChinaJiangsu Institute of Marine Resources Development, Jiangsu Ocean University, Lianyungang, ChinaPolychlorinated biphenyls (PCBs) are environmentally persistent and highly toxic organochlorine compounds that may cause toxic effects on aquatic animals. In this study we assess the toxic effect of PCBs on a bivalve used in aquaculture, the clam Cyclina sinensis. To this end, individuals of C. sinensis were exposed for 72 h at two PCB concentrations (1 ng/L and 10 ng/L) and control (absence of PCBs). At the end of the exposure, the hemolymph, hepatopancreas, and gills samples of C. sinensis were harvested for analysis of the enzyme activity and histology. The results showed that acute PCBs exposure decreased the survival rate of C. sinensis compared to the control. Acute PCBs exposure up-regulated the enzymatic activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) and the content of malondialdehyde (MDA) in the hemolymph of C. sinensis, while down-regulated the non-specific enzymatic activity of alkaline phosphatase (AKP). For the hepatopancreas, 1 ng/L PCBs exposure up-regulated the enzymatic activity of SOD while down-regulated the enzymatic activity of CAT of C. sinensis. In the gill, the enzymatic activity of CAT decreased significantly and the MDA content increased of C. sinensis after 10 ng/L PCBs exposure. Moreover, histological observations showed that acute exposure to PCBs caused loss of gill filaments and lateral cilia and shortening of their length, in the studied organism. The present study will provide valuable reference data for marine shellfish aquaculture and toxicology research.https://www.frontiersin.org/articles/10.3389/fmars.2023.1076870/fullbivalveecotoxicologyaquaculturenon-specific immunitychemical stress |
| spellingShingle | Meimei Liu Meimei Liu Sishao Fan Sishao Fan Zhichao Rong Zhichao Rong Hao Qiu Hao Qiu Susu Yan Susu Yan Hongwei Ni Hongwei Ni Zhiguo Dong Zhiguo Dong Zhiguo Dong Exposure to polychlorinated biphenyls (PCBs) affects the histology and antioxidant capability of the clam Cyclina sinensis Frontiers in Marine Science bivalve ecotoxicology aquaculture non-specific immunity chemical stress |
| title | Exposure to polychlorinated biphenyls (PCBs) affects the histology and antioxidant capability of the clam Cyclina sinensis |
| title_full | Exposure to polychlorinated biphenyls (PCBs) affects the histology and antioxidant capability of the clam Cyclina sinensis |
| title_fullStr | Exposure to polychlorinated biphenyls (PCBs) affects the histology and antioxidant capability of the clam Cyclina sinensis |
| title_full_unstemmed | Exposure to polychlorinated biphenyls (PCBs) affects the histology and antioxidant capability of the clam Cyclina sinensis |
| title_short | Exposure to polychlorinated biphenyls (PCBs) affects the histology and antioxidant capability of the clam Cyclina sinensis |
| title_sort | exposure to polychlorinated biphenyls pcbs affects the histology and antioxidant capability of the clam cyclina sinensis |
| topic | bivalve ecotoxicology aquaculture non-specific immunity chemical stress |
| url | https://www.frontiersin.org/articles/10.3389/fmars.2023.1076870/full |
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