Rodent Models of Audiogenic Epilepsy: Genetic Aspects, Advantages, Current Problems and Perspectives
Animal models of epilepsy are of great importance in epileptology. They are used to study the mechanisms of epileptogenesis, and search for new genes and regulatory pathways involved in the development of epilepsy as well as screening new antiepileptic drugs. Today, many methods of modeling epilepsy...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/11/2934 |
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| author | David G. Garbuz Artem A. Davletshin Svetlana A. Litvinova Irina B. Fedotova Natalya M. Surina Inga I. Poletaeva |
| author_facet | David G. Garbuz Artem A. Davletshin Svetlana A. Litvinova Irina B. Fedotova Natalya M. Surina Inga I. Poletaeva |
| author_sort | David G. Garbuz |
| collection | DOAJ |
| description | Animal models of epilepsy are of great importance in epileptology. They are used to study the mechanisms of epileptogenesis, and search for new genes and regulatory pathways involved in the development of epilepsy as well as screening new antiepileptic drugs. Today, many methods of modeling epilepsy in animals are used, including electroconvulsive, pharmacological in intact animals, and genetic, with the predisposition for spontaneous or refractory epileptic seizures. Due to the simplicity of manipulation and universality, genetic models of audiogenic epilepsy in rodents stand out among this diversity. We tried to combine data on the genetics of audiogenic epilepsy in rodents, the relevance of various models of audiogenic epilepsy to certain epileptic syndromes in humans, and the advantages of using of rodent strains predisposed to audiogenic epilepsy in current epileptology. |
| first_indexed | 2024-03-09T18:27:46Z |
| format | Article |
| id | doaj.art-cb600b2103524073a79bf797df4b3f3c |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T18:27:46Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-cb600b2103524073a79bf797df4b3f3c2023-11-24T07:46:26ZengMDPI AGBiomedicines2227-90592022-11-011011293410.3390/biomedicines10112934Rodent Models of Audiogenic Epilepsy: Genetic Aspects, Advantages, Current Problems and PerspectivesDavid G. Garbuz0Artem A. Davletshin1Svetlana A. Litvinova2Irina B. Fedotova3Natalya M. Surina4Inga I. Poletaeva5Laboratory of Molecular Mechanisms of Biological Adaptation, Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, RussiaLaboratory of Molecular Mechanisms of Biological Adaptation, Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, RussiaLaboratory of Psychopharmacology of FSBI “Zakusov Institute of Pharmacology”, 125315 Moscow, RussiaChair of Higher Nervous Activity, Biology Department, Lomonosov Moscow State University, 119991 Moscow, RussiaChair of Higher Nervous Activity, Biology Department, Lomonosov Moscow State University, 119991 Moscow, RussiaChair of Higher Nervous Activity, Biology Department, Lomonosov Moscow State University, 119991 Moscow, RussiaAnimal models of epilepsy are of great importance in epileptology. They are used to study the mechanisms of epileptogenesis, and search for new genes and regulatory pathways involved in the development of epilepsy as well as screening new antiepileptic drugs. Today, many methods of modeling epilepsy in animals are used, including electroconvulsive, pharmacological in intact animals, and genetic, with the predisposition for spontaneous or refractory epileptic seizures. Due to the simplicity of manipulation and universality, genetic models of audiogenic epilepsy in rodents stand out among this diversity. We tried to combine data on the genetics of audiogenic epilepsy in rodents, the relevance of various models of audiogenic epilepsy to certain epileptic syndromes in humans, and the advantages of using of rodent strains predisposed to audiogenic epilepsy in current epileptology.https://www.mdpi.com/2227-9059/10/11/2934audiogenic epilepsygenetic epilepsy modelsepilepsy-associated genesKM ratsWAR ratsGASH/Sal hamster strain |
| spellingShingle | David G. Garbuz Artem A. Davletshin Svetlana A. Litvinova Irina B. Fedotova Natalya M. Surina Inga I. Poletaeva Rodent Models of Audiogenic Epilepsy: Genetic Aspects, Advantages, Current Problems and Perspectives Biomedicines audiogenic epilepsy genetic epilepsy models epilepsy-associated genes KM rats WAR rats GASH/Sal hamster strain |
| title | Rodent Models of Audiogenic Epilepsy: Genetic Aspects, Advantages, Current Problems and Perspectives |
| title_full | Rodent Models of Audiogenic Epilepsy: Genetic Aspects, Advantages, Current Problems and Perspectives |
| title_fullStr | Rodent Models of Audiogenic Epilepsy: Genetic Aspects, Advantages, Current Problems and Perspectives |
| title_full_unstemmed | Rodent Models of Audiogenic Epilepsy: Genetic Aspects, Advantages, Current Problems and Perspectives |
| title_short | Rodent Models of Audiogenic Epilepsy: Genetic Aspects, Advantages, Current Problems and Perspectives |
| title_sort | rodent models of audiogenic epilepsy genetic aspects advantages current problems and perspectives |
| topic | audiogenic epilepsy genetic epilepsy models epilepsy-associated genes KM rats WAR rats GASH/Sal hamster strain |
| url | https://www.mdpi.com/2227-9059/10/11/2934 |
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