Inflammation in Development and Aging: Insights from the Zebrafish Model
Zebrafish are an emergent animal model to study human diseases due to their significant genetic similarity to humans, swift development, and genetic manipulability. Their utility extends to the exploration of the involvement of inflammation in host defense, immune responses, and tissue regeneration....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/25/4/2145 |
| _version_ | 1797298037047951360 |
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| author | Marta Mastrogiovanni Francisco Juan Martínez-Navarro Teresa V. Bowman María L. Cayuela |
| author_facet | Marta Mastrogiovanni Francisco Juan Martínez-Navarro Teresa V. Bowman María L. Cayuela |
| author_sort | Marta Mastrogiovanni |
| collection | DOAJ |
| description | Zebrafish are an emergent animal model to study human diseases due to their significant genetic similarity to humans, swift development, and genetic manipulability. Their utility extends to the exploration of the involvement of inflammation in host defense, immune responses, and tissue regeneration. Additionally, the zebrafish model system facilitates prompt screening of chemical compounds that affect inflammation. This study explored the diverse roles of inflammatory pathways in zebrafish development and aging. Serving as a crucial model, zebrafish provides insights into the intricate interplay of inflammation in both developmental and aging contexts. The evidence presented suggests that the same inflammatory signaling pathways often play instructive or beneficial roles during embryogenesis and are associated with malignancies in adults. |
| first_indexed | 2024-03-07T22:30:02Z |
| format | Article |
| id | doaj.art-cb60d540900241a38cedb694c6acb09c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-07T22:30:02Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-cb60d540900241a38cedb694c6acb09c2024-02-23T15:19:56ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01254214510.3390/ijms25042145Inflammation in Development and Aging: Insights from the Zebrafish ModelMarta Mastrogiovanni0Francisco Juan Martínez-Navarro1Teresa V. Bowman2María L. Cayuela3Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USAGrupo de Telomerasa, Cáncer y Envejecimiento, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, SpainDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USAGrupo de Telomerasa, Cáncer y Envejecimiento, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, SpainZebrafish are an emergent animal model to study human diseases due to their significant genetic similarity to humans, swift development, and genetic manipulability. Their utility extends to the exploration of the involvement of inflammation in host defense, immune responses, and tissue regeneration. Additionally, the zebrafish model system facilitates prompt screening of chemical compounds that affect inflammation. This study explored the diverse roles of inflammatory pathways in zebrafish development and aging. Serving as a crucial model, zebrafish provides insights into the intricate interplay of inflammation in both developmental and aging contexts. The evidence presented suggests that the same inflammatory signaling pathways often play instructive or beneficial roles during embryogenesis and are associated with malignancies in adults.https://www.mdpi.com/1422-0067/25/4/2145<i>Danio rerio</i>zebrafishinflammationagingdevelopmentimmunity |
| spellingShingle | Marta Mastrogiovanni Francisco Juan Martínez-Navarro Teresa V. Bowman María L. Cayuela Inflammation in Development and Aging: Insights from the Zebrafish Model International Journal of Molecular Sciences <i>Danio rerio</i> zebrafish inflammation aging development immunity |
| title | Inflammation in Development and Aging: Insights from the Zebrafish Model |
| title_full | Inflammation in Development and Aging: Insights from the Zebrafish Model |
| title_fullStr | Inflammation in Development and Aging: Insights from the Zebrafish Model |
| title_full_unstemmed | Inflammation in Development and Aging: Insights from the Zebrafish Model |
| title_short | Inflammation in Development and Aging: Insights from the Zebrafish Model |
| title_sort | inflammation in development and aging insights from the zebrafish model |
| topic | <i>Danio rerio</i> zebrafish inflammation aging development immunity |
| url | https://www.mdpi.com/1422-0067/25/4/2145 |
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