Evaluation of hematological parameters and lipid profile in dyspeptic patient with gastric Helicobacter pylori infection, southern Ethiopia, 2022 GC
Introduction: Helicobacter pylori is gram-negative bacteria that mainly inhabits the human stomach and is one of the causes of dyspepsia. However, it is not confined to gastrointestinal tract and extends its pathogenesis on other system. Purpose: To evaluate lipid profiles and hematologic markers in...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-04-01
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| Series: | Gastroenterology & Endoscopy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949752324000190 |
| _version_ | 1797214839805837312 |
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| author | Amanuel Abraham Behailu Tsegaye Mala George |
| author_facet | Amanuel Abraham Behailu Tsegaye Mala George |
| author_sort | Amanuel Abraham |
| collection | DOAJ |
| description | Introduction: Helicobacter pylori is gram-negative bacteria that mainly inhabits the human stomach and is one of the causes of dyspepsia. However, it is not confined to gastrointestinal tract and extends its pathogenesis on other system. Purpose: To evaluate lipid profiles and hematologic markers in dyspeptic individuals with and without H. pylori infection. Patients and methods: The comparative cross-sectional study was conducted at Arba Minch General Hospital, from February 2022 to July 2022, 51 H. Pylori positive and 51 H. pylori-negative dyspeptic patients were recruited for this study by a non-probability purposive sampling technique. Using a pretested questionnaire, socio-demographic and behavioral variables were gathered. H. pylori antigen was detected in human fecal samples using the H. pylori Ag cassette for infection diagnosis. Blood samples were taken to evaluate lipid profile and hematological markers. SPSS version 21 was used to analyze the data and a P-value of <0.05 was regarded as statistically significant for all variables. Results: The study's findings revealed that the H. pylori-positive and H. pylori-negative study groups had different mean deviations for hematological parameters (Hg, RBC, HCT, MCV, MCH, and RDW) and lipid profiles. In the H. Pylori positive group compared to H. pylori-negative patients, the mean value of RDW (13.98 ± 0.96 vs. 14.96 ± 1.38) increased whereas other hematological profiles declined. When compared to H. pylori-negative dyspeptic individuals, there was a drop in the mean value of HDL (40.92 ± 5.64 vs. 37.65 ± 5.88) and increased the mean values of TC, TG, and LDL in H. pylori-positive patients. HDL showed a positive significant relationship with Hgb, RBC, and HCT r = 0.39,r = 0.38,r = 0.43, respectively, while other lipid profiles (TC, TG, LDL) showed a negative significant correlation. Conclusion: The findings showed that H. pylori infection is related to altered lipid profiles and hematological markers, and HDL showed significant positive correlation with Hgb, RBC, and HCT. |
| first_indexed | 2024-04-24T11:20:33Z |
| format | Article |
| id | doaj.art-cb611ac4c7a74717acaa1d9dc4d85670 |
| institution | Directory Open Access Journal |
| issn | 2949-7523 |
| language | English |
| last_indexed | 2024-04-24T11:20:33Z |
| publishDate | 2024-04-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Gastroenterology & Endoscopy |
| spelling | doaj.art-cb611ac4c7a74717acaa1d9dc4d856702024-04-11T04:42:16ZengKeAi Communications Co., Ltd.Gastroenterology & Endoscopy2949-75232024-04-01229095Evaluation of hematological parameters and lipid profile in dyspeptic patient with gastric Helicobacter pylori infection, southern Ethiopia, 2022 GCAmanuel Abraham0Behailu Tsegaye1Mala George2Biomedical Science Department, Wachemo University, Hosanna, EthiopiaBiomedical Science Department, Arba Minch University, Arba Minch, Ethiopia; Corresponding author.Biomedical Science Department, University of Rwanda, RwandaIntroduction: Helicobacter pylori is gram-negative bacteria that mainly inhabits the human stomach and is one of the causes of dyspepsia. However, it is not confined to gastrointestinal tract and extends its pathogenesis on other system. Purpose: To evaluate lipid profiles and hematologic markers in dyspeptic individuals with and without H. pylori infection. Patients and methods: The comparative cross-sectional study was conducted at Arba Minch General Hospital, from February 2022 to July 2022, 51 H. Pylori positive and 51 H. pylori-negative dyspeptic patients were recruited for this study by a non-probability purposive sampling technique. Using a pretested questionnaire, socio-demographic and behavioral variables were gathered. H. pylori antigen was detected in human fecal samples using the H. pylori Ag cassette for infection diagnosis. Blood samples were taken to evaluate lipid profile and hematological markers. SPSS version 21 was used to analyze the data and a P-value of <0.05 was regarded as statistically significant for all variables. Results: The study's findings revealed that the H. pylori-positive and H. pylori-negative study groups had different mean deviations for hematological parameters (Hg, RBC, HCT, MCV, MCH, and RDW) and lipid profiles. In the H. Pylori positive group compared to H. pylori-negative patients, the mean value of RDW (13.98 ± 0.96 vs. 14.96 ± 1.38) increased whereas other hematological profiles declined. When compared to H. pylori-negative dyspeptic individuals, there was a drop in the mean value of HDL (40.92 ± 5.64 vs. 37.65 ± 5.88) and increased the mean values of TC, TG, and LDL in H. pylori-positive patients. HDL showed a positive significant relationship with Hgb, RBC, and HCT r = 0.39,r = 0.38,r = 0.43, respectively, while other lipid profiles (TC, TG, LDL) showed a negative significant correlation. Conclusion: The findings showed that H. pylori infection is related to altered lipid profiles and hematological markers, and HDL showed significant positive correlation with Hgb, RBC, and HCT.http://www.sciencedirect.com/science/article/pii/S2949752324000190H. pyloriHematological markerLipid profileSeverity of dyspeptic symptom |
| spellingShingle | Amanuel Abraham Behailu Tsegaye Mala George Evaluation of hematological parameters and lipid profile in dyspeptic patient with gastric Helicobacter pylori infection, southern Ethiopia, 2022 GC Gastroenterology & Endoscopy H. pylori Hematological marker Lipid profile Severity of dyspeptic symptom |
| title | Evaluation of hematological parameters and lipid profile in dyspeptic patient with gastric Helicobacter pylori infection, southern Ethiopia, 2022 GC |
| title_full | Evaluation of hematological parameters and lipid profile in dyspeptic patient with gastric Helicobacter pylori infection, southern Ethiopia, 2022 GC |
| title_fullStr | Evaluation of hematological parameters and lipid profile in dyspeptic patient with gastric Helicobacter pylori infection, southern Ethiopia, 2022 GC |
| title_full_unstemmed | Evaluation of hematological parameters and lipid profile in dyspeptic patient with gastric Helicobacter pylori infection, southern Ethiopia, 2022 GC |
| title_short | Evaluation of hematological parameters and lipid profile in dyspeptic patient with gastric Helicobacter pylori infection, southern Ethiopia, 2022 GC |
| title_sort | evaluation of hematological parameters and lipid profile in dyspeptic patient with gastric helicobacter pylori infection southern ethiopia 2022 gc |
| topic | H. pylori Hematological marker Lipid profile Severity of dyspeptic symptom |
| url | http://www.sciencedirect.com/science/article/pii/S2949752324000190 |
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