Egg yolk immunoglobulin interactions with Porphyromonas gingivalis to impact periodontal inflammation and halitosis
Abstract Porphyromonas gingivalis is a pathogenic Gram-negative anaerobic bacterium that colonizes the subgingival region of gums. These bacteria can invade periodontal tissues, form plaques, and produce volatile sulfur compounds (VSC) and volatile organic compounds (VOC). Egg yolk immunoglobulin (I...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2018-10-01
|
| Series: | AMB Express |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13568-018-0706-0 |
| _version_ | 1818060260768743424 |
|---|---|
| author | Wu Qiao Fang Wang Xiaochen Xu Shujun Wang Joe Mac Regenstein Bin Bao Ming Ma |
| author_facet | Wu Qiao Fang Wang Xiaochen Xu Shujun Wang Joe Mac Regenstein Bin Bao Ming Ma |
| author_sort | Wu Qiao |
| collection | DOAJ |
| description | Abstract Porphyromonas gingivalis is a pathogenic Gram-negative anaerobic bacterium that colonizes the subgingival region of gums. These bacteria can invade periodontal tissues, form plaques, and produce volatile sulfur compounds (VSC) and volatile organic compounds (VOC). Egg yolk immunoglobulin (IgY) that was specifically produced in egg yolks after chickens were challenged with P. gingivalis could control and prevent oral diseases caused by P. gingivalis. The releases of P. gingivalis offensive metabolic odors in vitro and in vivo were determined using a Halimeter and GCMS. With IgY bacterial growth was inhibited, and the relative amounts of VOC and VSC were decreased. The scores for the oral health index and the levels of IL-6 and TNF-α are also decreased. All treatment groups showed significant anti-inflammatory effects, which strongly suggests that specifically IgY against P. gingivalis may be an effective treatment for the prevention and protection of periodontal inflammation and halitosis. |
| first_indexed | 2024-12-10T13:29:36Z |
| format | Article |
| id | doaj.art-cb6270ff6d6341a58ee2b3178b1b75a9 |
| institution | Directory Open Access Journal |
| issn | 2191-0855 |
| language | English |
| last_indexed | 2024-12-10T13:29:36Z |
| publishDate | 2018-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | AMB Express |
| spelling | doaj.art-cb6270ff6d6341a58ee2b3178b1b75a92022-12-22T01:47:02ZengSpringerOpenAMB Express2191-08552018-10-018111210.1186/s13568-018-0706-0Egg yolk immunoglobulin interactions with Porphyromonas gingivalis to impact periodontal inflammation and halitosisWu Qiao0Fang Wang1Xiaochen Xu2Shujun Wang3Joe Mac Regenstein4Bin Bao5Ming Ma6College of Food Science and Technology, Shanghai Ocean UniversityShanghai University of Medicine & Health SciencesShanghai MAXAM Company LimitedCo-Innovation Center of Jiangsu Marine Bio-industry Technology, Huaihai Institute of TechnologyDepartment of Food Science, Cornell UniversityCollege of Food Science and Technology, Shanghai Ocean UniversityCollege of Food Science and Technology, Shanghai Ocean UniversityAbstract Porphyromonas gingivalis is a pathogenic Gram-negative anaerobic bacterium that colonizes the subgingival region of gums. These bacteria can invade periodontal tissues, form plaques, and produce volatile sulfur compounds (VSC) and volatile organic compounds (VOC). Egg yolk immunoglobulin (IgY) that was specifically produced in egg yolks after chickens were challenged with P. gingivalis could control and prevent oral diseases caused by P. gingivalis. The releases of P. gingivalis offensive metabolic odors in vitro and in vivo were determined using a Halimeter and GCMS. With IgY bacterial growth was inhibited, and the relative amounts of VOC and VSC were decreased. The scores for the oral health index and the levels of IL-6 and TNF-α are also decreased. All treatment groups showed significant anti-inflammatory effects, which strongly suggests that specifically IgY against P. gingivalis may be an effective treatment for the prevention and protection of periodontal inflammation and halitosis.http://link.springer.com/article/10.1186/s13568-018-0706-0Egg yolk immunoglobulinPorphyromonas gingivalisPeriodontal inflammationHalitosisVolatile sulfur compoundsVolatile organic compounds |
| spellingShingle | Wu Qiao Fang Wang Xiaochen Xu Shujun Wang Joe Mac Regenstein Bin Bao Ming Ma Egg yolk immunoglobulin interactions with Porphyromonas gingivalis to impact periodontal inflammation and halitosis AMB Express Egg yolk immunoglobulin Porphyromonas gingivalis Periodontal inflammation Halitosis Volatile sulfur compounds Volatile organic compounds |
| title | Egg yolk immunoglobulin interactions with Porphyromonas gingivalis to impact periodontal inflammation and halitosis |
| title_full | Egg yolk immunoglobulin interactions with Porphyromonas gingivalis to impact periodontal inflammation and halitosis |
| title_fullStr | Egg yolk immunoglobulin interactions with Porphyromonas gingivalis to impact periodontal inflammation and halitosis |
| title_full_unstemmed | Egg yolk immunoglobulin interactions with Porphyromonas gingivalis to impact periodontal inflammation and halitosis |
| title_short | Egg yolk immunoglobulin interactions with Porphyromonas gingivalis to impact periodontal inflammation and halitosis |
| title_sort | egg yolk immunoglobulin interactions with porphyromonas gingivalis to impact periodontal inflammation and halitosis |
| topic | Egg yolk immunoglobulin Porphyromonas gingivalis Periodontal inflammation Halitosis Volatile sulfur compounds Volatile organic compounds |
| url | http://link.springer.com/article/10.1186/s13568-018-0706-0 |
| work_keys_str_mv | AT wuqiao eggyolkimmunoglobulininteractionswithporphyromonasgingivalistoimpactperiodontalinflammationandhalitosis AT fangwang eggyolkimmunoglobulininteractionswithporphyromonasgingivalistoimpactperiodontalinflammationandhalitosis AT xiaochenxu eggyolkimmunoglobulininteractionswithporphyromonasgingivalistoimpactperiodontalinflammationandhalitosis AT shujunwang eggyolkimmunoglobulininteractionswithporphyromonasgingivalistoimpactperiodontalinflammationandhalitosis AT joemacregenstein eggyolkimmunoglobulininteractionswithporphyromonasgingivalistoimpactperiodontalinflammationandhalitosis AT binbao eggyolkimmunoglobulininteractionswithporphyromonasgingivalistoimpactperiodontalinflammationandhalitosis AT mingma eggyolkimmunoglobulininteractionswithporphyromonasgingivalistoimpactperiodontalinflammationandhalitosis |