Are clinical trials randomising households to lifestyle interventions to delay cognitive decline feasible? A pilot study to determine the beliefs, preferences, and deterrents for households impacted by dementia based on semi-structured interviews
Abstract Introduction While lifestyle risk factors are implicated in the development and progression of cognitive impairment, interventional trials of individual participants have yielded unconvincing evidence. We sought to explore the development of lifestyle interventions targeting the household-u...
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-022-02941-8 |
| _version_ | 1811332540432121856 |
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| author | Maria M. Costello Christine E. Mc Carthy Jackie Bosch Stephanie Robinson Clodagh McDermott Michelle D. Canavan Martin J. O’Donnell |
| author_facet | Maria M. Costello Christine E. Mc Carthy Jackie Bosch Stephanie Robinson Clodagh McDermott Michelle D. Canavan Martin J. O’Donnell |
| author_sort | Maria M. Costello |
| collection | DOAJ |
| description | Abstract Introduction While lifestyle risk factors are implicated in the development and progression of cognitive impairment, interventional trials of individual participants have yielded unconvincing evidence. We sought to explore the development of lifestyle interventions targeting the household-unit. Methods Semi-structured interviews were carried out among eight households affected by cognitive impairment (i.e. member of the household had cognitive impairment). Interviews took place online using a secure, web-based video platform recommended for patient clinician interaction. Interview content was analysed, and important themes identified. Results Eighteen participants were interviewed within households, of which eight (one per household) had cognitive impairment and others were spouses or first-degree relatives living in the same home. Several themes emerged; 1) household members without cognitive impairment were more likely to report poor sleep habits, and sleep was perceived to be the hardest behaviour to change; 2) diet generated most interest as a potential lifestyle intervention target as most participants believed there is a strong link with nutrition and cognition; 3) physical activity is challenging to adapt due to lack of motivation and focus when individuals are cognitively impaired. Barriers to study participation, including risk of harm, complexity of intervention and deviation from routine emerged during discussions. Conclusions This study identified beliefs and preferences of households towards lifestyle intervention trials. Findings from this study may be used to inform future clinical trial protocols and future qualitative studies should explore acceptability and feasibility of digital intervention applications. |
| first_indexed | 2024-04-13T16:37:33Z |
| format | Article |
| id | doaj.art-cb67857b0ce047a78044105f77dbd4db |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-04-13T16:37:33Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-cb67857b0ce047a78044105f77dbd4db2022-12-22T02:39:22ZengBMCBMC Geriatrics1471-23182022-04-0122111210.1186/s12877-022-02941-8Are clinical trials randomising households to lifestyle interventions to delay cognitive decline feasible? A pilot study to determine the beliefs, preferences, and deterrents for households impacted by dementia based on semi-structured interviewsMaria M. Costello0Christine E. Mc Carthy1Jackie Bosch2Stephanie Robinson3Clodagh McDermott4Michelle D. Canavan5Martin J. O’Donnell6HRB-Clinical Research Facility, National University of Ireland GalwayHRB-Clinical Research Facility, National University of Ireland GalwaySchool of Rehabilitation Science, McMaster UniversityHRB-Clinical Research Facility, National University of Ireland GalwayHRB-Clinical Research Facility, National University of Ireland GalwayHRB-Clinical Research Facility, National University of Ireland GalwayHRB-Clinical Research Facility, National University of Ireland GalwayAbstract Introduction While lifestyle risk factors are implicated in the development and progression of cognitive impairment, interventional trials of individual participants have yielded unconvincing evidence. We sought to explore the development of lifestyle interventions targeting the household-unit. Methods Semi-structured interviews were carried out among eight households affected by cognitive impairment (i.e. member of the household had cognitive impairment). Interviews took place online using a secure, web-based video platform recommended for patient clinician interaction. Interview content was analysed, and important themes identified. Results Eighteen participants were interviewed within households, of which eight (one per household) had cognitive impairment and others were spouses or first-degree relatives living in the same home. Several themes emerged; 1) household members without cognitive impairment were more likely to report poor sleep habits, and sleep was perceived to be the hardest behaviour to change; 2) diet generated most interest as a potential lifestyle intervention target as most participants believed there is a strong link with nutrition and cognition; 3) physical activity is challenging to adapt due to lack of motivation and focus when individuals are cognitively impaired. Barriers to study participation, including risk of harm, complexity of intervention and deviation from routine emerged during discussions. Conclusions This study identified beliefs and preferences of households towards lifestyle intervention trials. Findings from this study may be used to inform future clinical trial protocols and future qualitative studies should explore acceptability and feasibility of digital intervention applications.https://doi.org/10.1186/s12877-022-02941-8CaregiversDementiaLifestyle interventionsBehavioural changeQualitative |
| spellingShingle | Maria M. Costello Christine E. Mc Carthy Jackie Bosch Stephanie Robinson Clodagh McDermott Michelle D. Canavan Martin J. O’Donnell Are clinical trials randomising households to lifestyle interventions to delay cognitive decline feasible? A pilot study to determine the beliefs, preferences, and deterrents for households impacted by dementia based on semi-structured interviews BMC Geriatrics Caregivers Dementia Lifestyle interventions Behavioural change Qualitative |
| title | Are clinical trials randomising households to lifestyle interventions to delay cognitive decline feasible? A pilot study to determine the beliefs, preferences, and deterrents for households impacted by dementia based on semi-structured interviews |
| title_full | Are clinical trials randomising households to lifestyle interventions to delay cognitive decline feasible? A pilot study to determine the beliefs, preferences, and deterrents for households impacted by dementia based on semi-structured interviews |
| title_fullStr | Are clinical trials randomising households to lifestyle interventions to delay cognitive decline feasible? A pilot study to determine the beliefs, preferences, and deterrents for households impacted by dementia based on semi-structured interviews |
| title_full_unstemmed | Are clinical trials randomising households to lifestyle interventions to delay cognitive decline feasible? A pilot study to determine the beliefs, preferences, and deterrents for households impacted by dementia based on semi-structured interviews |
| title_short | Are clinical trials randomising households to lifestyle interventions to delay cognitive decline feasible? A pilot study to determine the beliefs, preferences, and deterrents for households impacted by dementia based on semi-structured interviews |
| title_sort | are clinical trials randomising households to lifestyle interventions to delay cognitive decline feasible a pilot study to determine the beliefs preferences and deterrents for households impacted by dementia based on semi structured interviews |
| topic | Caregivers Dementia Lifestyle interventions Behavioural change Qualitative |
| url | https://doi.org/10.1186/s12877-022-02941-8 |
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