Histamine-2 receptor antagonists versus proton pump inhibitors for septic shock after lower gastrointestinal tract perforation: a retrospective cohort study using a national inpatient database

Histamine-2 receptor antagonists versus proton pump inhibitors for septic shock after lower gastrointestinal tract perforation: a retrospective cohort study using a national inpatient database

Abstract Background Studies have shown the potential benefit of stress ulcer prophylaxis including histamine-2 receptor antagonists (H2RA) and proton pump inhibitors (PPI) in critically ill patients. However, the adverse effects of stress ulcer prophylaxis such as Clostridioides difficile infection...

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Bibliographic Details
Main Authors: Jun Suzuki, Yusuke Sasabuchi, Shuji Hatakeyama, Hiroki Matsui, Teppei Sasahara, Yuji Morisawa, Toshiyuki Yamada, Hideo Yasunaga
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Intensive Care
Subjects:
Bleeding
Clostridioides difficile infection
Histamine-2 receptor antagonists
Mortality
Hospital-acquired pneumonia
Proton pump inhibitors
Online Access:http://link.springer.com/article/10.1186/s40560-020-00473-0

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