Assessment of radial artery atherosclerosis in acute coronary syndrome patients: an in vivo study using optical coherence tomography
Abstract Background Radial artery (RA) atherosclerosis in acute coronary syndrome (ACS) patients has not been systematically observed in vivo. The study aims to characterize plaque morphology and intimal hyperplasia of the RA in patients with ACS, using optical coherence tomography (OCT). Methods In...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-022-02561-5 |
| _version_ | 1811331921606606848 |
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| author | Zixuan Li Zhe Tang Yujie Wang Zijing Liu Guozhong Wang Libin Zhang Yongxia Wu Jincheng Guo |
| author_facet | Zixuan Li Zhe Tang Yujie Wang Zijing Liu Guozhong Wang Libin Zhang Yongxia Wu Jincheng Guo |
| author_sort | Zixuan Li |
| collection | DOAJ |
| description | Abstract Background Radial artery (RA) atherosclerosis in acute coronary syndrome (ACS) patients has not been systematically observed in vivo. The study aims to characterize plaque morphology and intimal hyperplasia of the RA in patients with ACS, using optical coherence tomography (OCT). Methods In this retrospective study involving 239 ACS patients underwent RA OCT without guidewire shadow, 3 groups were divided according to the following criteria: radial artery plaque (RAP) group included patients with fibrous, lipid or calcified plaque; patients without RAP were further classified into radial intimal hyperplasia (RIH) group (intima media thickness ratio [IMR] ≥ 1) or normal group (IMR < 1). The presence and characteristics of RAP and its related risk factors were identified. Results The RAP, RIH and normal groups included 76 (31.8%), 69 (28.9%) and 94 (39.3%) patients, respectively. Patients in RAP group were the oldest, compared with those in the RIH and normal groups (p < 0.001), and more frequently had triple vessel disease (p = 0.004). The percentage of plaque rupture (72.4% vs. 56.4%, p = 0.018) and calcification (42.1% vs. 27.6%, p = 0.026) at culprit lesion were significantly higher in patients with RAP than those without RAP. A total of 148 RAP were revealed by OCT, including fibrous (72, 48.6%), lipid (50, 33.8%) and calcified plaques (26, 17.6%). The microvessels were also frequently observed in the RAP group than that in RIH and normal groups (59.2% vs. 8.7% vs. 9.6%, p < 0.001). Multivariate logistic regression analysis showed that age, diabetes, and smoking history (all p < 0.05) were independent risk factors for RAP. Conclusions In terms of insights gained from OCT, RA atherosclerosis is not uncommon in ACS patients by OCT, sharing several morphological characters with early coronary atherosclerosis. Aging, diabetes, and smoking are risk factors for RAP. |
| first_indexed | 2024-04-13T16:29:01Z |
| format | Article |
| id | doaj.art-cb6c06f164564934b01005b77d6471b3 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-13T16:29:01Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-cb6c06f164564934b01005b77d6471b32022-12-22T02:39:40ZengBMCBMC Cardiovascular Disorders1471-22612022-03-0122111110.1186/s12872-022-02561-5Assessment of radial artery atherosclerosis in acute coronary syndrome patients: an in vivo study using optical coherence tomographyZixuan Li0Zhe Tang1Yujie Wang2Zijing Liu3Guozhong Wang4Libin Zhang5Yongxia Wu6Jincheng Guo7Department of Cardiology, Beijing Luhe Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Luhe Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Luhe Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Luhe Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Luhe Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Luhe Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Luhe Hospital, Capital Medical UniversityAbstract Background Radial artery (RA) atherosclerosis in acute coronary syndrome (ACS) patients has not been systematically observed in vivo. The study aims to characterize plaque morphology and intimal hyperplasia of the RA in patients with ACS, using optical coherence tomography (OCT). Methods In this retrospective study involving 239 ACS patients underwent RA OCT without guidewire shadow, 3 groups were divided according to the following criteria: radial artery plaque (RAP) group included patients with fibrous, lipid or calcified plaque; patients without RAP were further classified into radial intimal hyperplasia (RIH) group (intima media thickness ratio [IMR] ≥ 1) or normal group (IMR < 1). The presence and characteristics of RAP and its related risk factors were identified. Results The RAP, RIH and normal groups included 76 (31.8%), 69 (28.9%) and 94 (39.3%) patients, respectively. Patients in RAP group were the oldest, compared with those in the RIH and normal groups (p < 0.001), and more frequently had triple vessel disease (p = 0.004). The percentage of plaque rupture (72.4% vs. 56.4%, p = 0.018) and calcification (42.1% vs. 27.6%, p = 0.026) at culprit lesion were significantly higher in patients with RAP than those without RAP. A total of 148 RAP were revealed by OCT, including fibrous (72, 48.6%), lipid (50, 33.8%) and calcified plaques (26, 17.6%). The microvessels were also frequently observed in the RAP group than that in RIH and normal groups (59.2% vs. 8.7% vs. 9.6%, p < 0.001). Multivariate logistic regression analysis showed that age, diabetes, and smoking history (all p < 0.05) were independent risk factors for RAP. Conclusions In terms of insights gained from OCT, RA atherosclerosis is not uncommon in ACS patients by OCT, sharing several morphological characters with early coronary atherosclerosis. Aging, diabetes, and smoking are risk factors for RAP.https://doi.org/10.1186/s12872-022-02561-5Optical coherence tomographyAtherosclerosisRadial arteryPeripheral artery disease |
| spellingShingle | Zixuan Li Zhe Tang Yujie Wang Zijing Liu Guozhong Wang Libin Zhang Yongxia Wu Jincheng Guo Assessment of radial artery atherosclerosis in acute coronary syndrome patients: an in vivo study using optical coherence tomography BMC Cardiovascular Disorders Optical coherence tomography Atherosclerosis Radial artery Peripheral artery disease |
| title | Assessment of radial artery atherosclerosis in acute coronary syndrome patients: an in vivo study using optical coherence tomography |
| title_full | Assessment of radial artery atherosclerosis in acute coronary syndrome patients: an in vivo study using optical coherence tomography |
| title_fullStr | Assessment of radial artery atherosclerosis in acute coronary syndrome patients: an in vivo study using optical coherence tomography |
| title_full_unstemmed | Assessment of radial artery atherosclerosis in acute coronary syndrome patients: an in vivo study using optical coherence tomography |
| title_short | Assessment of radial artery atherosclerosis in acute coronary syndrome patients: an in vivo study using optical coherence tomography |
| title_sort | assessment of radial artery atherosclerosis in acute coronary syndrome patients an in vivo study using optical coherence tomography |
| topic | Optical coherence tomography Atherosclerosis Radial artery Peripheral artery disease |
| url | https://doi.org/10.1186/s12872-022-02561-5 |
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