MicroRNAs as potential diagnostic markers of glial brain tumors
Gliomas are the most invasive brain tumors characterized by high mortality and recurrence rates. Glioblastoma (GBM), a grade IV brain tumor, is known for its heterogeneity and resistance to therapy. Modern diagnostics of various forms of malignant brain tumors is carried out mainly by imaging method...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-12-01
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| Series: | Non-coding RNA Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054022000531 |
| _version_ | 1797204899787702272 |
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| author | Albert Sufianov Sema Begliarzade Tatiana Ilyasova Xun Xu Ozal Beylerli |
| author_facet | Albert Sufianov Sema Begliarzade Tatiana Ilyasova Xun Xu Ozal Beylerli |
| author_sort | Albert Sufianov |
| collection | DOAJ |
| description | Gliomas are the most invasive brain tumors characterized by high mortality and recurrence rates. Glioblastoma (GBM), a grade IV brain tumor, is known for its heterogeneity and resistance to therapy. Modern diagnostics of various forms of malignant brain tumors is carried out mainly by imaging methods, such as magnetic resonance imaging, electroencephalography, positron emission tomography, and tumor biopsy is also used. The disadvantages of these methods are their inaccuracy and invasiveness, which entails certain risks for the patient's health, so modern science has stepped up the search for more reliable and safe methods for diagnosing gliomas, including the search for novel biomarkers. MicroRNA (miRNAs), a class of small non-coding RNA, perform the most important functions in various biological processes. In recent years, great progress in the study of miRNAs paths associated with the GBM pathogenesis has been achieved. MiRNAs molecules were identified as diagnostic and prognostic biomarkers, and can also serve as therapeutic targets and agents. This review provides current knowledge about the role of miRNAs in the pathogenesis of glial brain tumors, as well as the potential use of miRNAs as diagnostic and therapeutic targets for gliomas. |
| first_indexed | 2024-04-11T18:51:06Z |
| format | Article |
| id | doaj.art-cb6c8c0c6dda4debb6ee264cad233910 |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-24T08:42:34Z |
| publishDate | 2022-12-01 |
| publisher | KeAi Communications Co., Ltd. |
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| series | Non-coding RNA Research |
| spelling | doaj.art-cb6c8c0c6dda4debb6ee264cad2339102024-04-16T15:16:24ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402022-12-0174242247MicroRNAs as potential diagnostic markers of glial brain tumorsAlbert Sufianov0Sema Begliarzade1Tatiana Ilyasova2Xun Xu3Ozal Beylerli4Department of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; Educational and Scientific Institute of Neurosurgery, Рeoples’ Friendship University of Russia (RUDN University), Moscow, RussiaRepublican Clinical Perinatal Center, Ufa, Republic of Bashkortostan, 450106, RussiaDepartment of Internal Diseases, Bashkir State Medical University, Ufa, Republic of Bashkortostan, 450008, RussiaDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, ChinaEducational and Scientific Institute of Neurosurgery, Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russia; Corresponding author. Educational and Scientific Institute of Neurosurgery, Рeoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation.Gliomas are the most invasive brain tumors characterized by high mortality and recurrence rates. Glioblastoma (GBM), a grade IV brain tumor, is known for its heterogeneity and resistance to therapy. Modern diagnostics of various forms of malignant brain tumors is carried out mainly by imaging methods, such as magnetic resonance imaging, electroencephalography, positron emission tomography, and tumor biopsy is also used. The disadvantages of these methods are their inaccuracy and invasiveness, which entails certain risks for the patient's health, so modern science has stepped up the search for more reliable and safe methods for diagnosing gliomas, including the search for novel biomarkers. MicroRNA (miRNAs), a class of small non-coding RNA, perform the most important functions in various biological processes. In recent years, great progress in the study of miRNAs paths associated with the GBM pathogenesis has been achieved. MiRNAs molecules were identified as diagnostic and prognostic biomarkers, and can also serve as therapeutic targets and agents. This review provides current knowledge about the role of miRNAs in the pathogenesis of glial brain tumors, as well as the potential use of miRNAs as diagnostic and therapeutic targets for gliomas.http://www.sciencedirect.com/science/article/pii/S2468054022000531Brain tumorsGlioblastomasmiRNAsMolecular markersDiagnostic markers |
| spellingShingle | Albert Sufianov Sema Begliarzade Tatiana Ilyasova Xun Xu Ozal Beylerli MicroRNAs as potential diagnostic markers of glial brain tumors Non-coding RNA Research Brain tumors Glioblastomas miRNAs Molecular markers Diagnostic markers |
| title | MicroRNAs as potential diagnostic markers of glial brain tumors |
| title_full | MicroRNAs as potential diagnostic markers of glial brain tumors |
| title_fullStr | MicroRNAs as potential diagnostic markers of glial brain tumors |
| title_full_unstemmed | MicroRNAs as potential diagnostic markers of glial brain tumors |
| title_short | MicroRNAs as potential diagnostic markers of glial brain tumors |
| title_sort | micrornas as potential diagnostic markers of glial brain tumors |
| topic | Brain tumors Glioblastomas miRNAs Molecular markers Diagnostic markers |
| url | http://www.sciencedirect.com/science/article/pii/S2468054022000531 |
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