Evidence for Sexual Dimorphism in the Response to TLR3 Activation in the Developing Neonatal Mouse Brain: A Pilot Study

Evidence for Sexual Dimorphism in the Response to TLR3 Activation in the Developing Neonatal Mouse Brain: A Pilot Study

Toll-like receptor (TLR)3 activation during the neonatal period produces responses linked to the origins of neuropsychiatric disorders. Although there is sexual dimorphism in neuropsychiatric disorders, it is unknown if brain responses to TLR3 activation are sex-specific. We hypothesized that poly I...

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Bibliographic Details
Main Authors: Raul Chavez-Valdez, Amin Mottahedin, Linnea Stridh, Tracylyn R. Yellowhair, Lauren L. Jantzie, Frances J. Northington, Carina Mallard
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Physiology
Subjects:
poly I:C
inflammation
caspase
cytokines
astroglia
microglia
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00306/full

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