Zika and Chikungunya Virus and Risk for Venous Thromboembolism
A variety of viral infections are associated with hypercoagulable states and may be linked to the development of deep venous thrombosis and pulmonary embolism. The Zika and Chikungunya viral infections spread through the South and Central American continents, moving to North America in 2016, with se...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-01-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/1076029618821184 |
| _version_ | 1819007883143020544 |
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| author | Eduardo Ramacciotti MD, PhD Leandro B. Agati PhD Valéria C. R. Aguiar MD Nelson Wolosker MD, PhD João C. Guerra MD, PhD Roque P. de Almeida MD, PhD Juliana Cardoso Alves MD Renato D. Lopes MD, PhD Thomas W. Wakefield MD Anthony J. Comerota MD Jeanine Walenga PhD Jawed Fareed PhD |
| author_facet | Eduardo Ramacciotti MD, PhD Leandro B. Agati PhD Valéria C. R. Aguiar MD Nelson Wolosker MD, PhD João C. Guerra MD, PhD Roque P. de Almeida MD, PhD Juliana Cardoso Alves MD Renato D. Lopes MD, PhD Thomas W. Wakefield MD Anthony J. Comerota MD Jeanine Walenga PhD Jawed Fareed PhD |
| author_sort | Eduardo Ramacciotti MD, PhD |
| collection | DOAJ |
| description | A variety of viral infections are associated with hypercoagulable states and may be linked to the development of deep venous thrombosis and pulmonary embolism. The Zika and Chikungunya viral infections spread through the South and Central American continents, moving to North America in 2016, with severe cases of polyarthralgia, fever, and Guillain-Barré syndrome leading eventually to death. A decreased trend for both infections was reported in the first quarter of 2017. In this article, we report the possible association of venous thromboembolic events associated with Zika infection. After 2 cases of deep venous thrombosis in patients with acute Zika infections, D-dimer levels were measured in 172 consecutive patients who presented to the emergency department of a university hospital in an endemic region of Brazil with either Zika or Chikungunya infections confirmed by polymerase chain reaction tests. D-dimer levels were increased in 19.4% of 31 patients with Zika and in 63.8% of 141 patients with Chikungunya infections. The mechanisms behind this association are yet to be elucidated as well as the potential for venous thromboembolism prevention strategies for in-hospital patients affected by Zika and Chikungunya infections. |
| first_indexed | 2024-12-21T00:31:39Z |
| format | Article |
| id | doaj.art-cb6d40a98a884ede8da3150135de779f |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-12-21T00:31:39Z |
| publishDate | 2019-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-cb6d40a98a884ede8da3150135de779f2022-12-21T19:21:53ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232019-01-012510.1177/1076029618821184Zika and Chikungunya Virus and Risk for Venous ThromboembolismEduardo Ramacciotti MD, PhD0Leandro B. Agati PhD1Valéria C. R. Aguiar MD2Nelson Wolosker MD, PhD3João C. Guerra MD, PhD4Roque P. de Almeida MD, PhD5Juliana Cardoso Alves MD6Renato D. Lopes MD, PhD7Thomas W. Wakefield MD8Anthony J. Comerota MD9Jeanine Walenga PhD10Jawed Fareed PhD11 Hospital e Maternidade Dr. Christovão da Gama, Santo André, São Paulo, Brazil Hospital e Maternidade Dr. Christovão da Gama, Santo André, São Paulo, Brazil Hospital e Maternidade Dr. Christovão da Gama, Santo André, São Paulo, Brazil Hospital Israelita Albert Einstein, São Paulo, SP, Brazil Hospital Israelita Albert Einstein, São Paulo, SP, Brazil Universidade Federal de Sergipe, Aracajú, SE, Brazil Universidade Federal de Sergipe, Aracajú, SE, Brazil Duke University Hospital, Duke Clinical, Durham, NC, USA Michigan Medicine, Cardiovascular Center, University of Michigan, Ann arbor, MI, USA Mercy St. Vincent Medical Center, Toledo, OH, USA Loyola University Medical Center, Maywood, IL, USA Loyola University Medical Center, Maywood, IL, USAA variety of viral infections are associated with hypercoagulable states and may be linked to the development of deep venous thrombosis and pulmonary embolism. The Zika and Chikungunya viral infections spread through the South and Central American continents, moving to North America in 2016, with severe cases of polyarthralgia, fever, and Guillain-Barré syndrome leading eventually to death. A decreased trend for both infections was reported in the first quarter of 2017. In this article, we report the possible association of venous thromboembolic events associated with Zika infection. After 2 cases of deep venous thrombosis in patients with acute Zika infections, D-dimer levels were measured in 172 consecutive patients who presented to the emergency department of a university hospital in an endemic region of Brazil with either Zika or Chikungunya infections confirmed by polymerase chain reaction tests. D-dimer levels were increased in 19.4% of 31 patients with Zika and in 63.8% of 141 patients with Chikungunya infections. The mechanisms behind this association are yet to be elucidated as well as the potential for venous thromboembolism prevention strategies for in-hospital patients affected by Zika and Chikungunya infections.https://doi.org/10.1177/1076029618821184 |
| spellingShingle | Eduardo Ramacciotti MD, PhD Leandro B. Agati PhD Valéria C. R. Aguiar MD Nelson Wolosker MD, PhD João C. Guerra MD, PhD Roque P. de Almeida MD, PhD Juliana Cardoso Alves MD Renato D. Lopes MD, PhD Thomas W. Wakefield MD Anthony J. Comerota MD Jeanine Walenga PhD Jawed Fareed PhD Zika and Chikungunya Virus and Risk for Venous Thromboembolism Clinical and Applied Thrombosis/Hemostasis |
| title | Zika and Chikungunya Virus and Risk for Venous Thromboembolism |
| title_full | Zika and Chikungunya Virus and Risk for Venous Thromboembolism |
| title_fullStr | Zika and Chikungunya Virus and Risk for Venous Thromboembolism |
| title_full_unstemmed | Zika and Chikungunya Virus and Risk for Venous Thromboembolism |
| title_short | Zika and Chikungunya Virus and Risk for Venous Thromboembolism |
| title_sort | zika and chikungunya virus and risk for venous thromboembolism |
| url | https://doi.org/10.1177/1076029618821184 |
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