Definition, estimation and limitations of the dominant frequency in intracardiac electrograms
Intracardiac electrogram recordings during atrial fibrillation (AFib) are characterized by irregular rhythms and complex morphologies. Hence, analysis in the time domain is a difficult task. The so called dominant frequency DF is a spectrum based approach that aims at finding the most relevant frequ...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2017-09-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2017-0175 |
| _version_ | 1827969068460670976 |
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| author | Schwaderlapp Gerald Oesterlein Tobias Dössel Olaf Armin Luik Schmitt Claus Lenis Gustavo |
| author_facet | Schwaderlapp Gerald Oesterlein Tobias Dössel Olaf Armin Luik Schmitt Claus Lenis Gustavo |
| author_sort | Schwaderlapp Gerald |
| collection | DOAJ |
| description | Intracardiac electrogram recordings during atrial fibrillation (AFib) are characterized by irregular rhythms and complex morphologies. Hence, analysis in the time domain is a difficult task. The so called dominant frequency DF is a spectrum based approach that aims at finding the most relevant frequency in a signal providing information about the rate and dynamics of AFib. However, in recent years various studies reported controversial results regarding the clinical relevance of the DF. In this work, a definition of the DF at a fundamental scale is proposed as the rate at which action potentials are triggered in atrial cells. The most common method to estimate the DF in literature, labeled as DFSpec, is examined in comparison to the proposed definition. A signal processing study using synthetic signals verified that the DFSpec is stable for all changes in morphology of atrial activations. However, it is also demonstrated that the DFSpec becomes unstable for variations above 20% in the cycle length of a signal. Spectrum based DF estimation should be interpreted in a critical manner and is not advisable for study endpoints or clinical markers. |
| first_indexed | 2024-04-09T18:32:18Z |
| format | Article |
| id | doaj.art-cb734fb9c5f049bd899aa451008ef6c8 |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-04-09T18:32:18Z |
| publishDate | 2017-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-cb734fb9c5f049bd899aa451008ef6c82023-04-11T17:07:15ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042017-09-0132959810.1515/cdbme-2017-0175cdbme-2017-0175Definition, estimation and limitations of the dominant frequency in intracardiac electrogramsSchwaderlapp Gerald0Oesterlein Tobias1Dössel Olaf2Armin Luik3Schmitt Claus4Lenis Gustavo5Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 1, 76131 Karlsruhe, GermanyInstitute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, GermanyInstitute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, GermanyStädtisches Klinikum Karlsruhe, Karlsruhe, GermanyStädtisches Klinikum Karlsruhe, Karlsruhe, GermanyInstitute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, GermanyIntracardiac electrogram recordings during atrial fibrillation (AFib) are characterized by irregular rhythms and complex morphologies. Hence, analysis in the time domain is a difficult task. The so called dominant frequency DF is a spectrum based approach that aims at finding the most relevant frequency in a signal providing information about the rate and dynamics of AFib. However, in recent years various studies reported controversial results regarding the clinical relevance of the DF. In this work, a definition of the DF at a fundamental scale is proposed as the rate at which action potentials are triggered in atrial cells. The most common method to estimate the DF in literature, labeled as DFSpec, is examined in comparison to the proposed definition. A signal processing study using synthetic signals verified that the DFSpec is stable for all changes in morphology of atrial activations. However, it is also demonstrated that the DFSpec becomes unstable for variations above 20% in the cycle length of a signal. Spectrum based DF estimation should be interpreted in a critical manner and is not advisable for study endpoints or clinical markers.https://doi.org/10.1515/cdbme-2017-0175dominant frequencyatrial fibrillationsignal processingintracardiac electrogramcatheter ablation |
| spellingShingle | Schwaderlapp Gerald Oesterlein Tobias Dössel Olaf Armin Luik Schmitt Claus Lenis Gustavo Definition, estimation and limitations of the dominant frequency in intracardiac electrograms Current Directions in Biomedical Engineering dominant frequency atrial fibrillation signal processing intracardiac electrogram catheter ablation |
| title | Definition, estimation and limitations of the dominant frequency in intracardiac electrograms |
| title_full | Definition, estimation and limitations of the dominant frequency in intracardiac electrograms |
| title_fullStr | Definition, estimation and limitations of the dominant frequency in intracardiac electrograms |
| title_full_unstemmed | Definition, estimation and limitations of the dominant frequency in intracardiac electrograms |
| title_short | Definition, estimation and limitations of the dominant frequency in intracardiac electrograms |
| title_sort | definition estimation and limitations of the dominant frequency in intracardiac electrograms |
| topic | dominant frequency atrial fibrillation signal processing intracardiac electrogram catheter ablation |
| url | https://doi.org/10.1515/cdbme-2017-0175 |
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