Tight Junctions of the Neurovascular Unit
The homeostatic balance of the brain and retina is maintained by the presence of the blood-brain and inner blood-retinal barrier (BBB/iBRB, respectively) which are highly specialized barriers. Endothelial cells forming the lining of these blood vessels are interconnected by the presence of tight jun...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2021.752781/full |
| _version_ | 1818407235413344256 |
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| author | Natalie Hudson Matthew Campbell |
| author_facet | Natalie Hudson Matthew Campbell |
| author_sort | Natalie Hudson |
| collection | DOAJ |
| description | The homeostatic balance of the brain and retina is maintained by the presence of the blood-brain and inner blood-retinal barrier (BBB/iBRB, respectively) which are highly specialized barriers. Endothelial cells forming the lining of these blood vessels are interconnected by the presence of tight junctions which form the BBB and iBRB. These tight junctions, formed of numerous interacting proteins, enable the entry of molecules into neural tissues while restricting the entry of harmful material such as anaphylatoxins, bacteria and viruses. If the tight junction complex becomes dysregulated due to changes in expression levels of one or more of the components, this can have detrimental effects leading to brain and retinal pathology. |
| first_indexed | 2024-12-14T09:24:37Z |
| format | Article |
| id | doaj.art-cb749eae65cd4941967020af42c4dedd |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-14T09:24:37Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-cb749eae65cd4941967020af42c4dedd2022-12-21T23:08:13ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992021-11-011410.3389/fnmol.2021.752781752781Tight Junctions of the Neurovascular UnitNatalie HudsonMatthew CampbellThe homeostatic balance of the brain and retina is maintained by the presence of the blood-brain and inner blood-retinal barrier (BBB/iBRB, respectively) which are highly specialized barriers. Endothelial cells forming the lining of these blood vessels are interconnected by the presence of tight junctions which form the BBB and iBRB. These tight junctions, formed of numerous interacting proteins, enable the entry of molecules into neural tissues while restricting the entry of harmful material such as anaphylatoxins, bacteria and viruses. If the tight junction complex becomes dysregulated due to changes in expression levels of one or more of the components, this can have detrimental effects leading to brain and retinal pathology.https://www.frontiersin.org/articles/10.3389/fnmol.2021.752781/fulltight junctionneurovasculatureendothelial cellsblood brain barrierinner blood-retinal barrier |
| spellingShingle | Natalie Hudson Matthew Campbell Tight Junctions of the Neurovascular Unit Frontiers in Molecular Neuroscience tight junction neurovasculature endothelial cells blood brain barrier inner blood-retinal barrier |
| title | Tight Junctions of the Neurovascular Unit |
| title_full | Tight Junctions of the Neurovascular Unit |
| title_fullStr | Tight Junctions of the Neurovascular Unit |
| title_full_unstemmed | Tight Junctions of the Neurovascular Unit |
| title_short | Tight Junctions of the Neurovascular Unit |
| title_sort | tight junctions of the neurovascular unit |
| topic | tight junction neurovasculature endothelial cells blood brain barrier inner blood-retinal barrier |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2021.752781/full |
| work_keys_str_mv | AT nataliehudson tightjunctionsoftheneurovascularunit AT matthewcampbell tightjunctionsoftheneurovascularunit |