The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test

The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test

Aims: The number of approved drugs for the clinical treatment of Alzheimer disease remains limited. For this reason, there is extensive search for novel therapies. Of these, cholinesterase inhibitors have some proven benefit in slowing the disease progression and still remain the first-line therapeu...

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Bibliographic Details
Main Authors: Jan Misik, Jan Korabecny, Eugenie Nepovimova, Pavla Cabelova, Jiri Kassa
Format: Article
Language:English
Published: Palacký University Olomouc, Faculty of Medicine and Dentistry 2015-12-01
Series:Biomedical Papers
Subjects:
acetylcholine
acetylcholinesterase
alzheimer disease
spatial orientation
donepezil
tacrine
Online Access:https://biomed.papers.upol.cz/artkey/bio-201504-0006_The_effects_of_novel_7-MEOTA-donepezil_like_hybrids_and_N-alkylated_tacrine_analogues_in_the_treatment_of_quinu.php

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