Identification of Novel HBV/HDV Entry Inhibitors by Pharmacophore- and QSAR-Guided Virtual Screening

Identification of Novel HBV/HDV Entry Inhibitors by Pharmacophore- and QSAR-Guided Virtual Screening

The hepatic bile acid transporter Na<sup>+</sup>/taurocholate co-transporting polypeptide (NTCP) was identified in 2012 as the high-affinity hepatic receptor for the hepatitis B and D viruses (HBV/HDV). Since then, this carrier has emerged as promising drug target for HBV/HDV virus entry...

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Bibliographic Details
Main Authors: Michael Kirstgen, Simon Franz Müller, Kira Alessandra Alicia Theresa Lowjaga, Nora Goldmann, Felix Lehmann, Sami Alakurtti, Jari Yli-Kauhaluoma, Karl-Heinz Baringhaus, Reimar Krieg, Dieter Glebe, Joachim Geyer
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Viruses
Subjects:
HBV
HDV
NTCP
entry inhibitor
QSAR
pharmacophore
Online Access:https://www.mdpi.com/1999-4915/13/8/1489

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