Selective androgen receptor modulators for the treatment of late onset male hypogonadism
Several testosterone preparations are used in the treatment of hypogonadism in the ageing male. These therapies differ in their convenience, flexibility, regional availability and expense but share their pharmacokinetic basis of approval and dearth of long-term safety data. The brevity and relativel...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2014-04-01
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| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=2;spage=256;epage=261;aulast=Coss |
| _version_ | 1811194715487338496 |
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| author | Christopher C Coss Amanda Jones Michael L Hancock Mitchell S Steiner James T Dalton |
| author_facet | Christopher C Coss Amanda Jones Michael L Hancock Mitchell S Steiner James T Dalton |
| author_sort | Christopher C Coss |
| collection | DOAJ |
| description | Several testosterone preparations are used in the treatment of hypogonadism in the ageing male. These therapies differ in their convenience, flexibility, regional availability and expense but share their pharmacokinetic basis of approval and dearth of long-term safety data. The brevity and relatively reduced cost of pharmacokinetic based registration trials provides little commercial incentive to develop improved novel therapies for the treatment of late onset male hypogonadism. Selective androgen receptor modulators (SARMs) have been shown to provide anabolic benefit in the absence of androgenic effects on prostate, hair and skin. Current clinical development for SARMs is focused on acute muscle wasting conditions with defi ned clinical endpoints of physical function and lean body mass. Similar regulatory clarity concerning clinical deficits in men with hypogonadism is required before the beneficial pharmacology and desirable pharmacokinetics of SARMs can be employed in the treatment of late onset male hypogonadism. |
| first_indexed | 2024-04-12T00:31:21Z |
| format | Article |
| id | doaj.art-cb7a209083cf49388d5dbc9bca43efe1 |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-04-12T00:31:21Z |
| publishDate | 2014-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-cb7a209083cf49388d5dbc9bca43efe12022-12-22T03:55:20ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622014-04-0116225626110.4103/1008-682X.122339Selective androgen receptor modulators for the treatment of late onset male hypogonadismChristopher C CossAmanda JonesMichael L HancockMitchell S SteinerJames T DaltonSeveral testosterone preparations are used in the treatment of hypogonadism in the ageing male. These therapies differ in their convenience, flexibility, regional availability and expense but share their pharmacokinetic basis of approval and dearth of long-term safety data. The brevity and relatively reduced cost of pharmacokinetic based registration trials provides little commercial incentive to develop improved novel therapies for the treatment of late onset male hypogonadism. Selective androgen receptor modulators (SARMs) have been shown to provide anabolic benefit in the absence of androgenic effects on prostate, hair and skin. Current clinical development for SARMs is focused on acute muscle wasting conditions with defi ned clinical endpoints of physical function and lean body mass. Similar regulatory clarity concerning clinical deficits in men with hypogonadism is required before the beneficial pharmacology and desirable pharmacokinetics of SARMs can be employed in the treatment of late onset male hypogonadism.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=2;spage=256;epage=261;aulast=Cosshypogonadism; late onset hypogonadism; selective androgen receptor modulators; testosterone |
| spellingShingle | Christopher C Coss Amanda Jones Michael L Hancock Mitchell S Steiner James T Dalton Selective androgen receptor modulators for the treatment of late onset male hypogonadism Asian Journal of Andrology hypogonadism; late onset hypogonadism; selective androgen receptor modulators; testosterone |
| title | Selective androgen receptor modulators for the treatment of late onset male hypogonadism |
| title_full | Selective androgen receptor modulators for the treatment of late onset male hypogonadism |
| title_fullStr | Selective androgen receptor modulators for the treatment of late onset male hypogonadism |
| title_full_unstemmed | Selective androgen receptor modulators for the treatment of late onset male hypogonadism |
| title_short | Selective androgen receptor modulators for the treatment of late onset male hypogonadism |
| title_sort | selective androgen receptor modulators for the treatment of late onset male hypogonadism |
| topic | hypogonadism; late onset hypogonadism; selective androgen receptor modulators; testosterone |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=2;spage=256;epage=261;aulast=Coss |
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