Correlation of Pathogenesis, Early Diagnosis and Treatment of Colorectal Cancer with Microorganisms
Colorectal cancer is one of the major diseases that threaten human health. With the development of microbiome technology in recent years, many studies have reported the relation between microorganisms and the pathogenesis and development of colorectal cancer, such as Fusobacterium nucleatum and Bact...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2020-12-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://html.rhhz.net/ZLFZYJ/html/8578.2020.20.0596.htm |
| _version_ | 1818379929953239040 |
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| author | LU Wei XIAO Qian HU Yeting KONG Xiangxing DING Kefeng |
| author_facet | LU Wei XIAO Qian HU Yeting KONG Xiangxing DING Kefeng |
| author_sort | LU Wei |
| collection | DOAJ |
| description | Colorectal cancer is one of the major diseases that threaten human health. With the development of microbiome technology in recent years, many studies have reported the relation between microorganisms and the pathogenesis and development of colorectal cancer, such as Fusobacterium nucleatum and Bacteroides fragilis were found to induce and promote colorectal cancer. In addition, some researchers discovered the inhibitory effect of some bacterial metabolites such as short-chain fatty acids on the occurrence and development of colorectal cancer. Based on the differential microorganisms between colorectal cancer patients and healthy controls, the diagnostic model could be established. In the field of colorectal cancer treatment, microorganisms may become drug targets for inhibiting the occurrence and development of colorectal cancer, and they could influence the efficacy and side effects of chemotherapeutic drugs. Combined with the recent research progress and the author's own research interest, this article will review the correlation of pathogenesis, early diagnosis and treatment of colorectal cancer with microorganisms. |
| first_indexed | 2024-12-14T02:10:36Z |
| format | Article |
| id | doaj.art-cb7ab675d7ff41e8a58b81a3f40a3936 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 1000-8578 |
| language | zho |
| last_indexed | 2024-12-14T02:10:36Z |
| publishDate | 2020-12-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-cb7ab675d7ff41e8a58b81a3f40a39362022-12-21T23:20:46ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782020-12-01471290991410.3971/j.issn.1000-8578.2020.20.05968578.2020.20.0596Correlation of Pathogenesis, Early Diagnosis and Treatment of Colorectal Cancer with MicroorganismsLU Wei0XIAO Qian1HU Yeting2KONG Xiangxing3DING Kefeng4Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, ChinaDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, ChinaDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, ChinaDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, ChinaDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, ChinaColorectal cancer is one of the major diseases that threaten human health. With the development of microbiome technology in recent years, many studies have reported the relation between microorganisms and the pathogenesis and development of colorectal cancer, such as Fusobacterium nucleatum and Bacteroides fragilis were found to induce and promote colorectal cancer. In addition, some researchers discovered the inhibitory effect of some bacterial metabolites such as short-chain fatty acids on the occurrence and development of colorectal cancer. Based on the differential microorganisms between colorectal cancer patients and healthy controls, the diagnostic model could be established. In the field of colorectal cancer treatment, microorganisms may become drug targets for inhibiting the occurrence and development of colorectal cancer, and they could influence the efficacy and side effects of chemotherapeutic drugs. Combined with the recent research progress and the author's own research interest, this article will review the correlation of pathogenesis, early diagnosis and treatment of colorectal cancer with microorganisms.http://html.rhhz.net/ZLFZYJ/html/8578.2020.20.0596.htmmicroorganismscolorectal cancerpathogenesisearly diagnosistreatment |
| spellingShingle | LU Wei XIAO Qian HU Yeting KONG Xiangxing DING Kefeng Correlation of Pathogenesis, Early Diagnosis and Treatment of Colorectal Cancer with Microorganisms Zhongliu Fangzhi Yanjiu microorganisms colorectal cancer pathogenesis early diagnosis treatment |
| title | Correlation of Pathogenesis, Early Diagnosis and Treatment of Colorectal Cancer with Microorganisms |
| title_full | Correlation of Pathogenesis, Early Diagnosis and Treatment of Colorectal Cancer with Microorganisms |
| title_fullStr | Correlation of Pathogenesis, Early Diagnosis and Treatment of Colorectal Cancer with Microorganisms |
| title_full_unstemmed | Correlation of Pathogenesis, Early Diagnosis and Treatment of Colorectal Cancer with Microorganisms |
| title_short | Correlation of Pathogenesis, Early Diagnosis and Treatment of Colorectal Cancer with Microorganisms |
| title_sort | correlation of pathogenesis early diagnosis and treatment of colorectal cancer with microorganisms |
| topic | microorganisms colorectal cancer pathogenesis early diagnosis treatment |
| url | http://html.rhhz.net/ZLFZYJ/html/8578.2020.20.0596.htm |
| work_keys_str_mv | AT luwei correlationofpathogenesisearlydiagnosisandtreatmentofcolorectalcancerwithmicroorganisms AT xiaoqian correlationofpathogenesisearlydiagnosisandtreatmentofcolorectalcancerwithmicroorganisms AT huyeting correlationofpathogenesisearlydiagnosisandtreatmentofcolorectalcancerwithmicroorganisms AT kongxiangxing correlationofpathogenesisearlydiagnosisandtreatmentofcolorectalcancerwithmicroorganisms AT dingkefeng correlationofpathogenesisearlydiagnosisandtreatmentofcolorectalcancerwithmicroorganisms |