Hot-Melt Extruded Amorphous Solid Dispersion for Solubility, Stability, and Bioavailability Enhancement of Telmisartan
Telmisartan (TEL, an antihypertensive drug) belongs to Class II of the Biopharmaceutical Classification System (BCS) because of its poor aqueous solubility. In this study, we enhanced the solubility, bioavailability, and stability of TEL through the fabrication of TEL-loaded pH-modulated solid dispe...
Main Authors: | Bhupendra Raj Giri, Jaewook Kwon, Anh Q. Vo, Ajinkya M. Bhagurkar, Suresh Bandari, Dong Wuk Kim |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-01-01
|
Series: | Pharmaceuticals |
Subjects: | |
Online Access: | https://www.mdpi.com/1424-8247/14/1/73 |
Similar Items
-
A Hot-Melt Extrusion Risk Assessment Classification System for Amorphous Solid Dispersion Formulation Development
by: Samuel O. Kyeremateng, et al.
Published: (2022-05-01) -
Downstream Processing of Itraconazole:HPMCAS Amorphous Solid Dispersion: From Hot-Melt Extrudate to Tablet Using a Quality by Design Approach
by: Saurabh M Mishra, et al.
Published: (2022-07-01) -
The potential anticancer activities of telmisartan – a literature review
by: Andriana Hadjiyianni, et al.
Published: (2023-09-01) -
Immune pleiotropic effect of telmisartan in arterial hypertension
by: N. M. Agarkov, et al.
Published: (2022-07-01) -
Understanding the pH Dependence of Supersaturation State—A Case Study of Telmisartan
by: Szabina Kádár, et al.
Published: (2022-08-01)