Angiopoietin-2 Combined with Radiochemotherapy Impedes Glioblastoma Recurrence by Acting in an Autocrine and Paracrine Manner: A Preclinical Study

Angiopoietin-2 Combined with Radiochemotherapy Impedes Glioblastoma Recurrence by Acting in an Autocrine and Paracrine Manner: A Preclinical Study

(1) We wanted to assess the impact of Ang2 in RCT-induced changes in the environment of glioblastoma. (2) The effect of Ang2 overexpression in tumor cells was studied in the GL261 syngeneic immunocompetent model of GB in response to fractionated RCT. (3) We showed that RCT combined with Ang2 led to...

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Bibliographic Details
Main Authors: Charly Helaine, Aurélie E. Ferré, Marine M. Leblond, Elodie A. Pérès, Myriam Bernaudin, Samuel Valable, Edwige Petit
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
glioblastoma
angiopoietin-2
vascularization
inflammation
microenvironment
radiotherapy
Online Access:https://www.mdpi.com/2072-6694/12/12/3585

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