Why Septic Patients Remain Sick After Hospital Discharge?
Sepsis is well known to cause a high patient death rate (up to 50%) during the intensive care unit (ICU) stay. In addition, sepsis survival patients also exhibit a very high death rate after hospital discharge compared to patients with any other disease. The addressed question is then: why septic pa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.605666/full |
| _version_ | 1819178046964367360 |
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| author | Raquel Bragante Gritte Talita Souza-Siqueira Rui Curi Rui Curi Marcel Cerqueira Cesar Machado Francisco Garcia Soriano Francisco Garcia Soriano |
| author_facet | Raquel Bragante Gritte Talita Souza-Siqueira Rui Curi Rui Curi Marcel Cerqueira Cesar Machado Francisco Garcia Soriano Francisco Garcia Soriano |
| author_sort | Raquel Bragante Gritte |
| collection | DOAJ |
| description | Sepsis is well known to cause a high patient death rate (up to 50%) during the intensive care unit (ICU) stay. In addition, sepsis survival patients also exhibit a very high death rate after hospital discharge compared to patients with any other disease. The addressed question is then: why septic patients remain ill after hospital discharge? The cellular and molecular mechanisms involved in the high rate of septic patient deaths are still unknown. We described herein the studies that investigated the percentage of septic patients that died after hospital discharge ranging from 90 days up to 5 years. We also reported the symptoms of septic patients after hospital discharge and the development of the recently called post-sepsis syndrome (PSS). The most common symptoms of the PSS are cognitive disabilities, physical functioning decline, difficulties in performing routine daily activities, and poor life quality. The PSS also associates with quite often reinfection and re-hospitalization. This condition is the cause of the high rate of death mentioned above. We reported the proportion of patients dying after hospital discharge up to 5 years of followed up and the PSS symptoms associated. The authors also discuss the possible cellular and metabolic reprogramming mechanisms related with the low survival of septic patients and the occurrence of PSS. |
| first_indexed | 2024-12-22T21:36:20Z |
| format | Article |
| id | doaj.art-cb7b97dbd6f2431cb5ee73938334372a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T21:36:20Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-cb7b97dbd6f2431cb5ee73938334372a2022-12-21T18:11:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-02-011110.3389/fimmu.2020.605666605666Why Septic Patients Remain Sick After Hospital Discharge?Raquel Bragante Gritte0Talita Souza-Siqueira1Rui Curi2Rui Curi3Marcel Cerqueira Cesar Machado4Francisco Garcia Soriano5Francisco Garcia Soriano6Interdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, BrazilInterdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, BrazilInterdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, BrazilImmunobiological Production Section, Bioindustrial Center, Butantan Institute, São Paulo, BrazilDepartment of Emergency Medicine, University of São Paulo, São Paulo, BrazilUniversity Hospital, University of São Paulo, São Paulo, BrazilInternal Medicine Department, School of Medicine, University of São Paulo, São Paulo, BrazilSepsis is well known to cause a high patient death rate (up to 50%) during the intensive care unit (ICU) stay. In addition, sepsis survival patients also exhibit a very high death rate after hospital discharge compared to patients with any other disease. The addressed question is then: why septic patients remain ill after hospital discharge? The cellular and molecular mechanisms involved in the high rate of septic patient deaths are still unknown. We described herein the studies that investigated the percentage of septic patients that died after hospital discharge ranging from 90 days up to 5 years. We also reported the symptoms of septic patients after hospital discharge and the development of the recently called post-sepsis syndrome (PSS). The most common symptoms of the PSS are cognitive disabilities, physical functioning decline, difficulties in performing routine daily activities, and poor life quality. The PSS also associates with quite often reinfection and re-hospitalization. This condition is the cause of the high rate of death mentioned above. We reported the proportion of patients dying after hospital discharge up to 5 years of followed up and the PSS symptoms associated. The authors also discuss the possible cellular and metabolic reprogramming mechanisms related with the low survival of septic patients and the occurrence of PSS.https://www.frontiersin.org/articles/10.3389/fimmu.2020.605666/fullinflammationsepticemiapost sepsis syndromemetabolic reprogrammingleukocytes |
| spellingShingle | Raquel Bragante Gritte Talita Souza-Siqueira Rui Curi Rui Curi Marcel Cerqueira Cesar Machado Francisco Garcia Soriano Francisco Garcia Soriano Why Septic Patients Remain Sick After Hospital Discharge? Frontiers in Immunology inflammation septicemia post sepsis syndrome metabolic reprogramming leukocytes |
| title | Why Septic Patients Remain Sick After Hospital Discharge? |
| title_full | Why Septic Patients Remain Sick After Hospital Discharge? |
| title_fullStr | Why Septic Patients Remain Sick After Hospital Discharge? |
| title_full_unstemmed | Why Septic Patients Remain Sick After Hospital Discharge? |
| title_short | Why Septic Patients Remain Sick After Hospital Discharge? |
| title_sort | why septic patients remain sick after hospital discharge |
| topic | inflammation septicemia post sepsis syndrome metabolic reprogramming leukocytes |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.605666/full |
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