Electrochemotherapy in Aggressive Hemangioma of the Spine: A Case Series and Narrative Literature Review
(1) <b>Background:</b> this case series and literature review aims to evaluate the efficacy and safety of electrochemotherapy in the management of aggressive spinal hemangiomas, presenting two distinct cases. (2) <b>Methods:</b> we present two cases of spinal aggressive heman...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/5/1239 |
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| author | Giuseppe Tedesco Luigi Emanuele Noli Cristiana Griffoni Riccardo Ghermandi Giancarlo Facchini Giuliano Peta Nicolas Papalexis Emanuela Asunis Stefano Pasini Alessandro Gasbarrini |
| author_facet | Giuseppe Tedesco Luigi Emanuele Noli Cristiana Griffoni Riccardo Ghermandi Giancarlo Facchini Giuliano Peta Nicolas Papalexis Emanuela Asunis Stefano Pasini Alessandro Gasbarrini |
| author_sort | Giuseppe Tedesco |
| collection | DOAJ |
| description | (1) <b>Background:</b> this case series and literature review aims to evaluate the efficacy and safety of electrochemotherapy in the management of aggressive spinal hemangiomas, presenting two distinct cases. (2) <b>Methods:</b> we present two cases of spinal aggressive hemangioma which were refractory to conventional treatments and underwent electrochemotherapy. Case 1 involves a 50-year-old female who presented with an aggressive spinal hemangioma of L1, who previously underwent various treatments including surgery, radio-chemotherapy, and arterial embolization. Case 2 describes a 16-year-old female with a T12 vertebral hemangioma, previously treated with surgery and stabilization, who faced limitations in treatment options due to her young age and the location of the hemangioma. (3) <b>Results:</b> in Case 1, electrochemotherapy with bleomycin was administered following the failure of previous treatments and resulted in the reduction of the lesion size and improvement in clinical symptoms. In Case 2, electrochemotherapy was chosen due to the risks associated with other treatments and was completed without any adverse events. Both cases demonstrated the potential of electrochemotherapy as a viable treatment option for spinal hemangiomas, especially in complex or recurrent cases. (4) <b>Conclusions:</b> electrochemotherapy with bleomycin is a promising treatment for aggressive spinal hemangiomas when conventional therapies are not feasible or have failed. Further research is needed to establish definitive protocols and long-term outcomes of electrochemotherapy in spinal hemangioma management. |
| first_indexed | 2024-04-25T00:27:05Z |
| format | Article |
| id | doaj.art-cb7dbcd2a8144e5f9d3f1d6e5d20a023 |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-25T00:27:05Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-cb7dbcd2a8144e5f9d3f1d6e5d20a0232024-03-12T16:47:40ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-01135123910.3390/jcm13051239Electrochemotherapy in Aggressive Hemangioma of the Spine: A Case Series and Narrative Literature ReviewGiuseppe Tedesco0Luigi Emanuele Noli1Cristiana Griffoni2Riccardo Ghermandi3Giancarlo Facchini4Giuliano Peta5Nicolas Papalexis6Emanuela Asunis7Stefano Pasini8Alessandro Gasbarrini9Department of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Neurosurgery, IRCCS Istituto delle Scienze Neurologiche Bologna, Bellaria Hospital, 40139 Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDiagnostic and Interventional Radiology Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDiagnostic and Interventional Radiology Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDiagnostic and Interventional Radiology Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy(1) <b>Background:</b> this case series and literature review aims to evaluate the efficacy and safety of electrochemotherapy in the management of aggressive spinal hemangiomas, presenting two distinct cases. (2) <b>Methods:</b> we present two cases of spinal aggressive hemangioma which were refractory to conventional treatments and underwent electrochemotherapy. Case 1 involves a 50-year-old female who presented with an aggressive spinal hemangioma of L1, who previously underwent various treatments including surgery, radio-chemotherapy, and arterial embolization. Case 2 describes a 16-year-old female with a T12 vertebral hemangioma, previously treated with surgery and stabilization, who faced limitations in treatment options due to her young age and the location of the hemangioma. (3) <b>Results:</b> in Case 1, electrochemotherapy with bleomycin was administered following the failure of previous treatments and resulted in the reduction of the lesion size and improvement in clinical symptoms. In Case 2, electrochemotherapy was chosen due to the risks associated with other treatments and was completed without any adverse events. Both cases demonstrated the potential of electrochemotherapy as a viable treatment option for spinal hemangiomas, especially in complex or recurrent cases. (4) <b>Conclusions:</b> electrochemotherapy with bleomycin is a promising treatment for aggressive spinal hemangiomas when conventional therapies are not feasible or have failed. Further research is needed to establish definitive protocols and long-term outcomes of electrochemotherapy in spinal hemangioma management.https://www.mdpi.com/2077-0383/13/5/1239hemangiomaspineelectrochemotherapybleomycin |
| spellingShingle | Giuseppe Tedesco Luigi Emanuele Noli Cristiana Griffoni Riccardo Ghermandi Giancarlo Facchini Giuliano Peta Nicolas Papalexis Emanuela Asunis Stefano Pasini Alessandro Gasbarrini Electrochemotherapy in Aggressive Hemangioma of the Spine: A Case Series and Narrative Literature Review Journal of Clinical Medicine hemangioma spine electrochemotherapy bleomycin |
| title | Electrochemotherapy in Aggressive Hemangioma of the Spine: A Case Series and Narrative Literature Review |
| title_full | Electrochemotherapy in Aggressive Hemangioma of the Spine: A Case Series and Narrative Literature Review |
| title_fullStr | Electrochemotherapy in Aggressive Hemangioma of the Spine: A Case Series and Narrative Literature Review |
| title_full_unstemmed | Electrochemotherapy in Aggressive Hemangioma of the Spine: A Case Series and Narrative Literature Review |
| title_short | Electrochemotherapy in Aggressive Hemangioma of the Spine: A Case Series and Narrative Literature Review |
| title_sort | electrochemotherapy in aggressive hemangioma of the spine a case series and narrative literature review |
| topic | hemangioma spine electrochemotherapy bleomycin |
| url | https://www.mdpi.com/2077-0383/13/5/1239 |
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