Effects of Combinations of Toxin Binders with or without Natural Components on Broiler Breeders Exposed to Ochratoxin A
The objective of this study was to investigate the effects of toxin binders on broiler breeders fed an ochratoxin A (OTA)-contaminated diet. A total of 60 45-week-old female Arbor Acres broiler breeder birds with an initial body weight of 3.65 ± 0.35 kg were randomly divided into 6 treatment groups,...
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MDPI AG
2023-07-01
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| Online Access: | https://www.mdpi.com/2076-2615/13/14/2266 |
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| author | Jihwan Lee Hyunah Cho Dongcheol Song Seyeon Chang Jaewoo An Jeonghun Nam Byoungkon Lee Sowoong Kim Woo Kyun Kim Jinho Cho |
| author_facet | Jihwan Lee Hyunah Cho Dongcheol Song Seyeon Chang Jaewoo An Jeonghun Nam Byoungkon Lee Sowoong Kim Woo Kyun Kim Jinho Cho |
| author_sort | Jihwan Lee |
| collection | DOAJ |
| description | The objective of this study was to investigate the effects of toxin binders on broiler breeders fed an ochratoxin A (OTA)-contaminated diet. A total of 60 45-week-old female Arbor Acres broiler breeder birds with an initial body weight of 3.65 ± 0.35 kg were randomly divided into 6 treatment groups, with 10 replicates per group and 1 bird per replicate. The trial was conducted for 9 weeks (including 1 week of adaptation). Feed additive 1 (FA1) was composed of clay minerals (85% bentonite and 12% clinoptilolite) with 3% charcoal. FA2 was composed of clay minerals (66.1% aluminosilicates) with natural components (0.8% artichoke and rosemary plant extracts), 7% yeast extract, 0.5% beta-glucans, and 25.6% carriers. The dietary treatment groups were as follows: (1) birds fed an OTA-free basal diet (Negative Control; NC); (2) lipopolysaccharide (LPS)-challenged birds fed a diet including OTA (4 mg/kg) (Positive Control, PC); (3) the PC with 0.05% FA1 (Treatment 1, T1); (4) the PC with 0.10% FA1 (Treatment 2, T2); (5) the PC with 0.10% FA2 (Treatment 3, T3); and (6) the PC with 0.20% FA2 (Treatment 4, T4). The LPS challenge (an intramuscular injection of 1 mg <i>E. coli</i> O55:B5 LPS per kg of body weight) was performed on the first day of the experiment. The results of this experiment show that the PC treatment negatively affected (<i>p</i> < 0.05) egg production, hatchability, Haugh unit, bone mineralization, relative organ weight (abdominal fat, liver), the levels of glutamic oxaloacetic transaminase (GOT), high-density lipoprotein (HDL), and total cholesterol in the blood, and OTA accumulation in the liver compared with the NC. However, supplementation with toxin binders mitigated (<i>p</i> < 0.05) the negative effects of the OTA. Specifically, supplementation with 0.10% FA1 and 0.10% FA2 increased (<i>p</i> < 0.05) eggshell strength by week 4, and the Haugh unit and bone mineralization (phosphorous) by week 8, while decreasing (<i>p</i> < 0.05) the relative weight of the liver and the levels of GOT and HDL in the blood. Supplementation with 0.10% FA2 led to greater improvements in various parameters, including laying performance and bone mineralization, than the other treatments. In conclusion, toxin binders with or without natural components can be effective tools in the mitigation of OTA-induced problems due to their synergistic effects. |
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| spelling | doaj.art-cb7ebfb762d044a695d9691d9fee15fe2023-11-18T17:59:53ZengMDPI AGAnimals2076-26152023-07-011314226610.3390/ani13142266Effects of Combinations of Toxin Binders with or without Natural Components on Broiler Breeders Exposed to Ochratoxin AJihwan Lee0Hyunah Cho1Dongcheol Song2Seyeon Chang3Jaewoo An4Jeonghun Nam5Byoungkon Lee6Sowoong Kim7Woo Kyun Kim8Jinho Cho9Department of Poultry Science, University of Georgia, Athens, GA 30602, USADepartment of Animal Science, Chungbuk National University, Cheongju 28644, Republic of KoreaDepartment of Animal Science, Chungbuk National University, Cheongju 28644, Republic of KoreaDepartment of Animal Science, Chungbuk National University, Cheongju 28644, Republic of KoreaDepartment of Animal Science, Chungbuk National University, Cheongju 28644, Republic of KoreaCherrybro Co., Ltd., Jincheon 27820, Republic of KoreaCherrybro Co., Ltd., Jincheon 27820, Republic of KoreaProvimi Co., Ltd., Seoul 06158, Republic of KoreaDepartment of Poultry Science, University of Georgia, Athens, GA 30602, USADepartment of Animal Science, Chungbuk National University, Cheongju 28644, Republic of KoreaThe objective of this study was to investigate the effects of toxin binders on broiler breeders fed an ochratoxin A (OTA)-contaminated diet. A total of 60 45-week-old female Arbor Acres broiler breeder birds with an initial body weight of 3.65 ± 0.35 kg were randomly divided into 6 treatment groups, with 10 replicates per group and 1 bird per replicate. The trial was conducted for 9 weeks (including 1 week of adaptation). Feed additive 1 (FA1) was composed of clay minerals (85% bentonite and 12% clinoptilolite) with 3% charcoal. FA2 was composed of clay minerals (66.1% aluminosilicates) with natural components (0.8% artichoke and rosemary plant extracts), 7% yeast extract, 0.5% beta-glucans, and 25.6% carriers. The dietary treatment groups were as follows: (1) birds fed an OTA-free basal diet (Negative Control; NC); (2) lipopolysaccharide (LPS)-challenged birds fed a diet including OTA (4 mg/kg) (Positive Control, PC); (3) the PC with 0.05% FA1 (Treatment 1, T1); (4) the PC with 0.10% FA1 (Treatment 2, T2); (5) the PC with 0.10% FA2 (Treatment 3, T3); and (6) the PC with 0.20% FA2 (Treatment 4, T4). The LPS challenge (an intramuscular injection of 1 mg <i>E. coli</i> O55:B5 LPS per kg of body weight) was performed on the first day of the experiment. The results of this experiment show that the PC treatment negatively affected (<i>p</i> < 0.05) egg production, hatchability, Haugh unit, bone mineralization, relative organ weight (abdominal fat, liver), the levels of glutamic oxaloacetic transaminase (GOT), high-density lipoprotein (HDL), and total cholesterol in the blood, and OTA accumulation in the liver compared with the NC. However, supplementation with toxin binders mitigated (<i>p</i> < 0.05) the negative effects of the OTA. Specifically, supplementation with 0.10% FA1 and 0.10% FA2 increased (<i>p</i> < 0.05) eggshell strength by week 4, and the Haugh unit and bone mineralization (phosphorous) by week 8, while decreasing (<i>p</i> < 0.05) the relative weight of the liver and the levels of GOT and HDL in the blood. Supplementation with 0.10% FA2 led to greater improvements in various parameters, including laying performance and bone mineralization, than the other treatments. In conclusion, toxin binders with or without natural components can be effective tools in the mitigation of OTA-induced problems due to their synergistic effects.https://www.mdpi.com/2076-2615/13/14/2266broiler breederochratoxin Atoxin binderclay mineralnatural component |
| spellingShingle | Jihwan Lee Hyunah Cho Dongcheol Song Seyeon Chang Jaewoo An Jeonghun Nam Byoungkon Lee Sowoong Kim Woo Kyun Kim Jinho Cho Effects of Combinations of Toxin Binders with or without Natural Components on Broiler Breeders Exposed to Ochratoxin A Animals broiler breeder ochratoxin A toxin binder clay mineral natural component |
| title | Effects of Combinations of Toxin Binders with or without Natural Components on Broiler Breeders Exposed to Ochratoxin A |
| title_full | Effects of Combinations of Toxin Binders with or without Natural Components on Broiler Breeders Exposed to Ochratoxin A |
| title_fullStr | Effects of Combinations of Toxin Binders with or without Natural Components on Broiler Breeders Exposed to Ochratoxin A |
| title_full_unstemmed | Effects of Combinations of Toxin Binders with or without Natural Components on Broiler Breeders Exposed to Ochratoxin A |
| title_short | Effects of Combinations of Toxin Binders with or without Natural Components on Broiler Breeders Exposed to Ochratoxin A |
| title_sort | effects of combinations of toxin binders with or without natural components on broiler breeders exposed to ochratoxin a |
| topic | broiler breeder ochratoxin A toxin binder clay mineral natural component |
| url | https://www.mdpi.com/2076-2615/13/14/2266 |
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