Combined treatment with valproic acid and estrogen has neuroprotective effects in ovariectomized mice with Alzheimer’s disease

Combined treatment with valproic acid and estrogen has neuroprotective effects in ovariectomized mice with Alzheimer’s disease

Postmenopausal women with Alzheimer’s disease (AD) exhibit dramatically reduced sensitivity to estrogen replacement therapy, which is though to be related to an estrogen receptor (ER)α/ERβ ratio imbalance arising from a significantly decreased level of ERs of the brain. The aim of our study was to i...

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Bibliographic Details
Main Authors: Yan-Zhen Li, Yuan-Jie Liu, Wei Zhang, Shi-Fang Luo, Xin Zhou, Gui-Qiong He
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Neural Regeneration Research
Subjects:
17β-estradiol; amyloid β; dementia; estrogen receptor α; estrogen receptor β; glycogen synthase kinase-3β; liquiritigenin; menopause; neuron loss; tau
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=10;spage=2078;epage=2085;aulast=Li

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