Features of a clinical course of the acute respiratory diseases caused by adenoviruses of epidemic significant serotypes
The objective: To investigate etiological structure of adenoviral diseases in young people from organized groups and the clinical features of acute respiratory disease caused by different serotypes of adenovirus were identified.Materials and methods: A total 382 patients with adenovirusinfections we...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2014-09-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/230 |
| _version_ | 1797702174912806912 |
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| author | N. I. L`vov A. A. Sominina K. V. Zhdanov Yu. V. Lobzin |
| author_facet | N. I. L`vov A. A. Sominina K. V. Zhdanov Yu. V. Lobzin |
| author_sort | N. I. L`vov |
| collection | DOAJ |
| description | The objective: To investigate etiological structure of adenoviral diseases in young people from organized groups and the clinical features of acute respiratory disease caused by different serotypes of adenovirus were identified.Materials and methods: A total 382 patients with adenovirusinfections were investigated. Virus isolation from nasopharyngeal swabs was carried out in cell cultures Vero, HeLa, Hep-2. Typing of adenoviruses was performed by virus neutralization test with polyclonal rabbit subtype specific sera. The average (M), standard deviation (SD) and frequency of occurrence (%) of clinical signs (respiratory and non-respiratory syndromes of pneumonia, protracted and recurrent course was calculated. Significance of the differences (p<0,05) of average frequency of cases compared to independent group of patients was evaluated by Student t-test and criterion φ2 (phi – square) Fischer, respectively.Results: As result of investigation 199 adenovirus strains (52,1 %) were isolated. 183 strains were serotyped: 64 (32,2 %) – 3 serotype, 42 (21,1 %) – 4 serotype, 38 (19,1 %) – 7 serotype, 15 (7,5 %) – 5 serotype, 11 (5,5 %) – 21 serotype, 8 (4,0 %) – 1 serotype, 3 (1,5 %) – 2 serotype, 2 (1,0 %) – 6 serotype. In assessing the features of the clinical course of adenoviral infection caused by the most actual serotypes (3, 4, 7) of adenovirus revealed that duration of diseases caused by serotype 7 was significantly longer and remained febrile fever (4,3±2,74 days, p<0,05), rhinitis (9,4±6,01 days, p<0,05), pharyngitis (7,9±2,87 days, p<0,05), laryngitis (7,3±2,87 days, p<0,05) and bronchitis (11,8±8,03 days, p<0,05), tonsillitis (63,0%, φ2=12,6, p<0,05), lymphadenopathy (63,0%, φ2=4,1, p<0,05), and pneumonia (34,2%, φ2=3,84, p<0,05) were registered significantly more frequently.Conclusion: The study showed that the adenoviruses of 3, 4 and 7 serotype have the greatest epidemiological significance. Clinical features of adenoviral diseases caused by 7 serotype were manifested in more frequent registration of non-respiratory syndromes and the development of pneumonia. |
| first_indexed | 2024-03-12T04:46:21Z |
| format | Article |
| id | doaj.art-cb7fde4c303143079bc2358d7891b600 |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2024-03-12T04:46:21Z |
| publishDate | 2014-09-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-cb7fde4c303143079bc2358d7891b6002023-09-03T09:28:13ZrusJournal InfectologyЖурнал инфектологии2072-67322014-09-016251110.22625/2072-6732-2014-6-2-5-11244Features of a clinical course of the acute respiratory diseases caused by adenoviruses of epidemic significant serotypesN. I. L`vov0A. A. Sominina1K. V. Zhdanov2Yu. V. Lobzin3Военно-медицинская академия им. С.М. Кирова, Санкт-Петербург, РоссияНаучно-исследовательский институт гриппа, Санкт-Петербург, РоссияВоенно-медицинская академия им. С.М. Кирова, Санкт-Петербург, РоссияНаучно-исследовательский институт детских инфекций ФМБА России, Санкт-Петербург, Россия Северо-Западный государственный медицинский университет им. И.И. Мечникова, Санкт-Петербург, РоссияThe objective: To investigate etiological structure of adenoviral diseases in young people from organized groups and the clinical features of acute respiratory disease caused by different serotypes of adenovirus were identified.Materials and methods: A total 382 patients with adenovirusinfections were investigated. Virus isolation from nasopharyngeal swabs was carried out in cell cultures Vero, HeLa, Hep-2. Typing of adenoviruses was performed by virus neutralization test with polyclonal rabbit subtype specific sera. The average (M), standard deviation (SD) and frequency of occurrence (%) of clinical signs (respiratory and non-respiratory syndromes of pneumonia, protracted and recurrent course was calculated. Significance of the differences (p<0,05) of average frequency of cases compared to independent group of patients was evaluated by Student t-test and criterion φ2 (phi – square) Fischer, respectively.Results: As result of investigation 199 adenovirus strains (52,1 %) were isolated. 183 strains were serotyped: 64 (32,2 %) – 3 serotype, 42 (21,1 %) – 4 serotype, 38 (19,1 %) – 7 serotype, 15 (7,5 %) – 5 serotype, 11 (5,5 %) – 21 serotype, 8 (4,0 %) – 1 serotype, 3 (1,5 %) – 2 serotype, 2 (1,0 %) – 6 serotype. In assessing the features of the clinical course of adenoviral infection caused by the most actual serotypes (3, 4, 7) of adenovirus revealed that duration of diseases caused by serotype 7 was significantly longer and remained febrile fever (4,3±2,74 days, p<0,05), rhinitis (9,4±6,01 days, p<0,05), pharyngitis (7,9±2,87 days, p<0,05), laryngitis (7,3±2,87 days, p<0,05) and bronchitis (11,8±8,03 days, p<0,05), tonsillitis (63,0%, φ2=12,6, p<0,05), lymphadenopathy (63,0%, φ2=4,1, p<0,05), and pneumonia (34,2%, φ2=3,84, p<0,05) were registered significantly more frequently.Conclusion: The study showed that the adenoviruses of 3, 4 and 7 serotype have the greatest epidemiological significance. Clinical features of adenoviral diseases caused by 7 serotype were manifested in more frequent registration of non-respiratory syndromes and the development of pneumonia.https://journal.niidi.ru/jofin/article/view/230аденовирусные заболеваниясеротипы аденовирусовклиническое течениепневмония |
| spellingShingle | N. I. L`vov A. A. Sominina K. V. Zhdanov Yu. V. Lobzin Features of a clinical course of the acute respiratory diseases caused by adenoviruses of epidemic significant serotypes Журнал инфектологии аденовирусные заболевания серотипы аденовирусов клиническое течение пневмония |
| title | Features of a clinical course of the acute respiratory diseases caused by adenoviruses of epidemic significant serotypes |
| title_full | Features of a clinical course of the acute respiratory diseases caused by adenoviruses of epidemic significant serotypes |
| title_fullStr | Features of a clinical course of the acute respiratory diseases caused by adenoviruses of epidemic significant serotypes |
| title_full_unstemmed | Features of a clinical course of the acute respiratory diseases caused by adenoviruses of epidemic significant serotypes |
| title_short | Features of a clinical course of the acute respiratory diseases caused by adenoviruses of epidemic significant serotypes |
| title_sort | features of a clinical course of the acute respiratory diseases caused by adenoviruses of epidemic significant serotypes |
| topic | аденовирусные заболевания серотипы аденовирусов клиническое течение пневмония |
| url | https://journal.niidi.ru/jofin/article/view/230 |
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