Synthesis, characterization and in vitro biological studies of novel Nitrilo derivatives of N-substituted phenyl piperazine
Nitrilo derivatives of N-alkyl and N-aryl phenyl piperazine have been synthesized and screened for antibacterial and antifungal activities. All the synthesized compounds showed the antibacterial activity against pathogenic strains of Staphylococcus aureus (MTCCB 737), Pseudomonas aeruginosa (MTCCB...
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| Format: | Article |
| Language: | English |
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University of Thi-Qar
2019-05-01
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| Series: | مجلة علوم ذي قار |
| Online Access: | http://jsci.utq.edu.iq/index.php/main/article/view/214 |
| _version_ | 1797404272803971072 |
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| author | Idries AL-Mashkor |
| author_facet | Idries AL-Mashkor |
| author_sort | Idries AL-Mashkor |
| collection | DOAJ |
| description |
Nitrilo derivatives of N-alkyl and N-aryl phenyl piperazine have been synthesized and
screened for antibacterial and antifungal activities. All the synthesized compounds showed the
antibacterial activity against pathogenic strains of Staphylococcus aureus (MTCCB 737),
Pseudomonas aeruginosa (MTCCB 741),Streptomyces epidermidis (MTCCB 1824) and
Escherichia coli(MTCCB 1652) and antifungal activity against pathogenic strains of
Aspergillus fumigatus (ITCC 4517), Aspergillus flavus (ITCC 5192) and Aspergillus niger
(ITCC 5405). All compounds showed mild to moderate antimicrobial activity. However,
compounds 3c, 4a and 6 showed potent antibacterial activity against pathogenic strains used
in the study. Compounds 3a, 3b, 4b, and 4d showed mild to moderate antifungal activity
against Aspergillus pathogenic strains.
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| first_indexed | 2024-03-09T02:52:34Z |
| format | Article |
| id | doaj.art-cb7fea6985514137b0ef1beff10694f4 |
| institution | Directory Open Access Journal |
| issn | 1991-8690 2709-0256 |
| language | English |
| last_indexed | 2024-03-09T02:52:34Z |
| publishDate | 2019-05-01 |
| publisher | University of Thi-Qar |
| record_format | Article |
| series | مجلة علوم ذي قار |
| spelling | doaj.art-cb7fea6985514137b0ef1beff10694f42023-12-05T09:57:42ZengUniversity of Thi-Qarمجلة علوم ذي قار1991-86902709-02562019-05-0131Synthesis, characterization and in vitro biological studies of novel Nitrilo derivatives of N-substituted phenyl piperazine Idries AL-Mashkor 0Department of Biochemistry - College of Medicine - University of Thi-qar Nitrilo derivatives of N-alkyl and N-aryl phenyl piperazine have been synthesized and screened for antibacterial and antifungal activities. All the synthesized compounds showed the antibacterial activity against pathogenic strains of Staphylococcus aureus (MTCCB 737), Pseudomonas aeruginosa (MTCCB 741),Streptomyces epidermidis (MTCCB 1824) and Escherichia coli(MTCCB 1652) and antifungal activity against pathogenic strains of Aspergillus fumigatus (ITCC 4517), Aspergillus flavus (ITCC 5192) and Aspergillus niger (ITCC 5405). All compounds showed mild to moderate antimicrobial activity. However, compounds 3c, 4a and 6 showed potent antibacterial activity against pathogenic strains used in the study. Compounds 3a, 3b, 4b, and 4d showed mild to moderate antifungal activity against Aspergillus pathogenic strains. http://jsci.utq.edu.iq/index.php/main/article/view/214 |
| spellingShingle | Idries AL-Mashkor Synthesis, characterization and in vitro biological studies of novel Nitrilo derivatives of N-substituted phenyl piperazine مجلة علوم ذي قار |
| title | Synthesis, characterization and in vitro biological studies of novel Nitrilo derivatives of N-substituted phenyl piperazine |
| title_full | Synthesis, characterization and in vitro biological studies of novel Nitrilo derivatives of N-substituted phenyl piperazine |
| title_fullStr | Synthesis, characterization and in vitro biological studies of novel Nitrilo derivatives of N-substituted phenyl piperazine |
| title_full_unstemmed | Synthesis, characterization and in vitro biological studies of novel Nitrilo derivatives of N-substituted phenyl piperazine |
| title_short | Synthesis, characterization and in vitro biological studies of novel Nitrilo derivatives of N-substituted phenyl piperazine |
| title_sort | synthesis characterization and in vitro biological studies of novel nitrilo derivatives of n substituted phenyl piperazine |
| url | http://jsci.utq.edu.iq/index.php/main/article/view/214 |
| work_keys_str_mv | AT idriesalmashkor synthesischaracterizationandinvitrobiologicalstudiesofnovelnitriloderivativesofnsubstitutedphenylpiperazine |