Biosynthesis of copperoxide nanoparticles using Abies spectabilis plant extract and analyzing its antinociceptive and anti-inflammatory potency in various mice models
Nanotechnology has shown rapid progress in various fields had made a remarkable change in the field of therapeutics too. The present study aims to synthesize and characterize the eco-friendly biocompatible copper oxide nanoparticles using Abies spectabilis plant extract (AS-CuONPs) and inspect its a...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535220302549 |
| _version_ | 1818432704833650688 |
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| author | Hongtao Liu SiMin Zheng HongFei Xiong Mona S Alwahibi Xiaoli Niu |
| author_facet | Hongtao Liu SiMin Zheng HongFei Xiong Mona S Alwahibi Xiaoli Niu |
| author_sort | Hongtao Liu |
| collection | DOAJ |
| description | Nanotechnology has shown rapid progress in various fields had made a remarkable change in the field of therapeutics too. The present study aims to synthesize and characterize the eco-friendly biocompatible copper oxide nanoparticles using Abies spectabilis plant extract (AS-CuONPs) and inspect its ameliorative potential against the different stimuli induced nociception and inflammatory reactions in mice. The formulated AS-CuONPs were characterized via the UV–vis spectroscopy, FT-IR, and TEM analysis. The nociception was induced by the method of acetic acid, glutamate, capsaicin, formalin, and thermal-induced techniques. The anti-inflammatory property of AS-CuONPs with carrageenan induced paw edema, peritoneal leukocyte infiltration, and carrageenan induced air pouch tests. Our result of UV–Visible spectroscopic analysis confirms the formation of AS-CuONPs and the characterization with FTIR and TEM proves the same. The result of various stimuli induced nociception models provide the evidence that formulated AS-CuONPs effectively inhibits the nociceptive responses in mice. Further the infiltration of leukocytes and inflammatory cytokines were drastically decreased by the AS-CuONPs treatment in the mice. The open field analysis confirms that the AS-CuONPs doesn’t impart any behavioral changes in mice. Over all our results confirms that AS-CuONPs is effective against different stimuli induced nociception and it act as a potent anti-inflammatory agent without rendering any side effects. |
| first_indexed | 2024-12-14T16:09:26Z |
| format | Article |
| id | doaj.art-cb80e45f391748d69667a9f9a529223c |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-14T16:09:26Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-cb80e45f391748d69667a9f9a529223c2022-12-21T22:55:01ZengElsevierArabian Journal of Chemistry1878-53522020-09-0113969957006Biosynthesis of copperoxide nanoparticles using Abies spectabilis plant extract and analyzing its antinociceptive and anti-inflammatory potency in various mice modelsHongtao Liu0SiMin Zheng1HongFei Xiong2Mona S Alwahibi3Xiaoli Niu4Department of Anesthesia, The Second Affiliated Hospital of Xi’an JiaoTong University, Xi’an, Shaanxi 710004, ChinaDepartment of Anesthesia, The Second Affiliated Hospital of Xi’an JiaoTong University, Xi’an, Shaanxi 710004, ChinaDepartment of Anesthesia, The Second Affiliated Hospital of Xi’an JiaoTong University, Xi’an, Shaanxi 710004, ChinaDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Anesthesia, The Second Affiliated Hospital of Xi’an JiaoTong University, Xi’an, Shaanxi 710004, China; Corresponding author.Nanotechnology has shown rapid progress in various fields had made a remarkable change in the field of therapeutics too. The present study aims to synthesize and characterize the eco-friendly biocompatible copper oxide nanoparticles using Abies spectabilis plant extract (AS-CuONPs) and inspect its ameliorative potential against the different stimuli induced nociception and inflammatory reactions in mice. The formulated AS-CuONPs were characterized via the UV–vis spectroscopy, FT-IR, and TEM analysis. The nociception was induced by the method of acetic acid, glutamate, capsaicin, formalin, and thermal-induced techniques. The anti-inflammatory property of AS-CuONPs with carrageenan induced paw edema, peritoneal leukocyte infiltration, and carrageenan induced air pouch tests. Our result of UV–Visible spectroscopic analysis confirms the formation of AS-CuONPs and the characterization with FTIR and TEM proves the same. The result of various stimuli induced nociception models provide the evidence that formulated AS-CuONPs effectively inhibits the nociceptive responses in mice. Further the infiltration of leukocytes and inflammatory cytokines were drastically decreased by the AS-CuONPs treatment in the mice. The open field analysis confirms that the AS-CuONPs doesn’t impart any behavioral changes in mice. Over all our results confirms that AS-CuONPs is effective against different stimuli induced nociception and it act as a potent anti-inflammatory agent without rendering any side effects.http://www.sciencedirect.com/science/article/pii/S1878535220302549Copper oxide nanoparticlesGreen synthesisAbies spectabilisAntinociceptionAnti-inflammation |
| spellingShingle | Hongtao Liu SiMin Zheng HongFei Xiong Mona S Alwahibi Xiaoli Niu Biosynthesis of copperoxide nanoparticles using Abies spectabilis plant extract and analyzing its antinociceptive and anti-inflammatory potency in various mice models Arabian Journal of Chemistry Copper oxide nanoparticles Green synthesis Abies spectabilis Antinociception Anti-inflammation |
| title | Biosynthesis of copperoxide nanoparticles using Abies spectabilis plant extract and analyzing its antinociceptive and anti-inflammatory potency in various mice models |
| title_full | Biosynthesis of copperoxide nanoparticles using Abies spectabilis plant extract and analyzing its antinociceptive and anti-inflammatory potency in various mice models |
| title_fullStr | Biosynthesis of copperoxide nanoparticles using Abies spectabilis plant extract and analyzing its antinociceptive and anti-inflammatory potency in various mice models |
| title_full_unstemmed | Biosynthesis of copperoxide nanoparticles using Abies spectabilis plant extract and analyzing its antinociceptive and anti-inflammatory potency in various mice models |
| title_short | Biosynthesis of copperoxide nanoparticles using Abies spectabilis plant extract and analyzing its antinociceptive and anti-inflammatory potency in various mice models |
| title_sort | biosynthesis of copperoxide nanoparticles using abies spectabilis plant extract and analyzing its antinociceptive and anti inflammatory potency in various mice models |
| topic | Copper oxide nanoparticles Green synthesis Abies spectabilis Antinociception Anti-inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S1878535220302549 |
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