Multiomic characterisation of the long-term sequelae of SARS survivors: a clinical observational studyResearch in context
Summary: Background: We aimed to characterise the long-term health outcomes of survivors of severe acute respiratory syndrome (SARS) and determine their recovery status and possible immunological basis. Methods: We performed a clinical observational study on 14 health workers who survived SARS coro...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | EClinicalMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537023000615 |
| _version_ | 1797893803503255552 |
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| author | Kuan Li Qian Wu Hongjie Li Haibai Sun Zhiheng Xing Li Li Huaiyong Chen |
| author_facet | Kuan Li Qian Wu Hongjie Li Haibai Sun Zhiheng Xing Li Li Huaiyong Chen |
| author_sort | Kuan Li |
| collection | DOAJ |
| description | Summary: Background: We aimed to characterise the long-term health outcomes of survivors of severe acute respiratory syndrome (SARS) and determine their recovery status and possible immunological basis. Methods: We performed a clinical observational study on 14 health workers who survived SARS coronavirus infection between Apr 20, 2003 and Jun 6, 2003 in Haihe Hospital (Tianjin, China). Eighteen years after discharge, SARS survivors were interviewed using questionnaires on symptoms and quality of life, and received physical examination, laboratory tests, pulmonary function tests, arterial blood gas analysis, and chest imaging. Plasma samples were collected for metabolomic, proteomic, and single-cell transcriptomic analyses. The health outcomes were compared 18 and 12 years after discharge. Control individuals were also health workers from the same hospital but did not infect with SARS coronavirus. Findings: Fatigue was the most common symptom in SARS survivors 18 years after discharge, with osteoporosis and necrosis of the femoral head being the main sequelae. The respiratory function and hip function scores of the SARS survivors were significantly lower than those of the controls. Physical and social functioning at 18 years was improved compared to that after 12 years but still worse than the controls. Emotional and mental health were fully recovered. Lung lesions on CT scans remained consistent at 18 years, especially in the right upper lobe and left lower lobe lesions. Plasma multiomics analysis indicated an abnormal metabolism of amino acids and lipids, promoted host defense immune responses to bacteria and external stimuli, B-cell activation, and enhanced cytotoxicity of CD8+ T cells but impaired antigen presentation capacity of CD4+ T cells. Interpretation: Although health outcomes continued to improve, our study suggested that SARS survivors still suffered from physical fatigue, osteoporosis, and necrosis of the femoral head 18 years after discharge, possibly related to plasma metabolic disorders and immunological alterations. Funding: This study was funded by the Tianjin Haihe Hospital Science and Technology Fund (HHYY-202012) and Tianjin Key Medical Discipline (Specialty) Construction Project (TJYXZDXK-063B, TJYXZDXK-067C). |
| first_indexed | 2024-04-10T06:59:02Z |
| format | Article |
| id | doaj.art-cb8383410a9f469aa37e22ba515f2ef0 |
| institution | Directory Open Access Journal |
| issn | 2589-5370 |
| language | English |
| last_indexed | 2024-04-10T06:59:02Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj.art-cb8383410a9f469aa37e22ba515f2ef02023-02-28T04:09:04ZengElsevierEClinicalMedicine2589-53702023-04-0158101884Multiomic characterisation of the long-term sequelae of SARS survivors: a clinical observational studyResearch in contextKuan Li0Qian Wu1Hongjie Li2Haibai Sun3Zhiheng Xing4Li Li5Huaiyong Chen6Department of Basic Medicine, Haihe Hospital, Tianjin University, Tianjin, ChinaDepartment of Respiratory Medicine, Haihe Hospital, Tianjin Medical University, Tianjin, ChinaDepartment of Clinical Laboratory, Haihe Hospital, Tianjin University, Tianjin, ChinaDepartment of Clinical Laboratory, Haihe Hospital, Tianjin University, Tianjin, China; Corresponding author.Department of Radiology, Haihe Hospital, Tianjin University, Tianjin, China; Corresponding author.Department of Respiratory Medicine, Haihe Hospital, Tianjin Medical University, Tianjin, China; Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin Institute of Respiratory Diseases, Tianjin, China; Tianjin Key Laboratory of Lung Regenerative Medicine, Tianjin, China; Corresponding author.Department of Basic Medicine, Haihe Hospital, Tianjin University, Tianjin, China; Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin Institute of Respiratory Diseases, Tianjin, China; Tianjin Key Laboratory of Lung Regenerative Medicine, Tianjin, China; Corresponding author. Haihe Hospital, Tianjin University, Tianjin 300350, PR China.Summary: Background: We aimed to characterise the long-term health outcomes of survivors of severe acute respiratory syndrome (SARS) and determine their recovery status and possible immunological basis. Methods: We performed a clinical observational study on 14 health workers who survived SARS coronavirus infection between Apr 20, 2003 and Jun 6, 2003 in Haihe Hospital (Tianjin, China). Eighteen years after discharge, SARS survivors were interviewed using questionnaires on symptoms and quality of life, and received physical examination, laboratory tests, pulmonary function tests, arterial blood gas analysis, and chest imaging. Plasma samples were collected for metabolomic, proteomic, and single-cell transcriptomic analyses. The health outcomes were compared 18 and 12 years after discharge. Control individuals were also health workers from the same hospital but did not infect with SARS coronavirus. Findings: Fatigue was the most common symptom in SARS survivors 18 years after discharge, with osteoporosis and necrosis of the femoral head being the main sequelae. The respiratory function and hip function scores of the SARS survivors were significantly lower than those of the controls. Physical and social functioning at 18 years was improved compared to that after 12 years but still worse than the controls. Emotional and mental health were fully recovered. Lung lesions on CT scans remained consistent at 18 years, especially in the right upper lobe and left lower lobe lesions. Plasma multiomics analysis indicated an abnormal metabolism of amino acids and lipids, promoted host defense immune responses to bacteria and external stimuli, B-cell activation, and enhanced cytotoxicity of CD8+ T cells but impaired antigen presentation capacity of CD4+ T cells. Interpretation: Although health outcomes continued to improve, our study suggested that SARS survivors still suffered from physical fatigue, osteoporosis, and necrosis of the femoral head 18 years after discharge, possibly related to plasma metabolic disorders and immunological alterations. Funding: This study was funded by the Tianjin Haihe Hospital Science and Technology Fund (HHYY-202012) and Tianjin Key Medical Discipline (Specialty) Construction Project (TJYXZDXK-063B, TJYXZDXK-067C).http://www.sciencedirect.com/science/article/pii/S2589537023000615SARSLong-term sequelaeImmune functionMultiomics analysisRespiratory functions |
| spellingShingle | Kuan Li Qian Wu Hongjie Li Haibai Sun Zhiheng Xing Li Li Huaiyong Chen Multiomic characterisation of the long-term sequelae of SARS survivors: a clinical observational studyResearch in context EClinicalMedicine SARS Long-term sequelae Immune function Multiomics analysis Respiratory functions |
| title | Multiomic characterisation of the long-term sequelae of SARS survivors: a clinical observational studyResearch in context |
| title_full | Multiomic characterisation of the long-term sequelae of SARS survivors: a clinical observational studyResearch in context |
| title_fullStr | Multiomic characterisation of the long-term sequelae of SARS survivors: a clinical observational studyResearch in context |
| title_full_unstemmed | Multiomic characterisation of the long-term sequelae of SARS survivors: a clinical observational studyResearch in context |
| title_short | Multiomic characterisation of the long-term sequelae of SARS survivors: a clinical observational studyResearch in context |
| title_sort | multiomic characterisation of the long term sequelae of sars survivors a clinical observational studyresearch in context |
| topic | SARS Long-term sequelae Immune function Multiomics analysis Respiratory functions |
| url | http://www.sciencedirect.com/science/article/pii/S2589537023000615 |
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