Improving social function with real-world social-cognitive remediation in schizophrenia: Results from the RemedRugby quasi-experimental trial
AbstractBackground.Functional capacity (FC) has been identified as a key outcome to improve real-world functioning in schizophrenia. FC is influenced by cognitive impairments, negative symptoms, self-stigma and reduced physical activity (PA). Psychosocial interventions targeting FC are still under-d...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2020-01-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933820000425/type/journal_article |
| _version_ | 1811156335220228096 |
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| author | Julien Dubreucq Franck Gabayet Bernard Ycart Megane Faraldo Fanny Melis Thierry Lucas Benjamin Arnaud Mickael Bacconnier Motassem Bakri Gentiane Cambier Florian Carmona Isabelle Chereau Titaua Challe Sophie Morel Sylvie Pires Celine Roussel Philippe Lamy Guillaume Legrand Emmanuelle Pages Romain Pommier Romain Rey Yohan Souchet Pierre-Michel Llorca Catherine Massoubre the RemedRugby Group |
| author_facet | Julien Dubreucq Franck Gabayet Bernard Ycart Megane Faraldo Fanny Melis Thierry Lucas Benjamin Arnaud Mickael Bacconnier Motassem Bakri Gentiane Cambier Florian Carmona Isabelle Chereau Titaua Challe Sophie Morel Sylvie Pires Celine Roussel Philippe Lamy Guillaume Legrand Emmanuelle Pages Romain Pommier Romain Rey Yohan Souchet Pierre-Michel Llorca Catherine Massoubre the RemedRugby Group |
| author_sort | Julien Dubreucq |
| collection | DOAJ |
| description | AbstractBackground.Functional capacity (FC) has been identified as a key outcome to improve real-world functioning in schizophrenia. FC is influenced by cognitive impairments, negative symptoms, self-stigma and reduced physical activity (PA). Psychosocial interventions targeting FC are still under-developed.Methods.we conducted a quasi-experimental study evaluating the effects of an exercise-enriched integrated social cognitive remediation (SCR) intervention (RemedRugby [RR]) compared with an active control group practicing Touch Rugby (TR). To our knowledge, this is the first trial to date evaluating the effectiveness of such a program provided in a real-life environment.Results.Eighty-seven people with schizophrenia were included and allocated to either the RR group (n = 57) or the TR group (n = 30) according to the routine clinical practice of the recruiting center. Outcomes were evaluated at baseline and post-treatment in both groups and after 6 months of follow-up in the RR group using standardized scales for symptom severity, social functioning, self-stigma, and a large cognitive battery. After treatment we observed moderate to large improvements in social function (Personal and Social Performance Scale [PSP], p < 0.001, d = 1.255), symptom severity (Positive and Negative Syndrome Scale [PANSS] negative, p < 0.001, d = 0.827; PANSS GP, p < 0.001, d = 0.991; PANSS positive, p = 0.009, d = 0.594), verbal abstraction (p = 0.008, d = 0.554), aggression bias (p = 0.008, d = 0.627), and self-stigma (stereotype endorsement, p = 0.019, d = 0.495; discrimination experiences, p = 0.047; d = 0.389) that were specific to the RR group and were not observed in participants playing only TR. Effects were persistent over time and even larger between post-treatment and follow-up.Conclusions.Exercise-enriched integrated SCR appears promising to improve real-life functioning in schizophrenia. Future research should investigate the potential effects of this intervention on neuroplasticity and physical fitness. |
| first_indexed | 2024-04-10T04:49:47Z |
| format | Article |
| id | doaj.art-cb83b59e87934180968c73a15242008b |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-04-10T04:49:47Z |
| publishDate | 2020-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-cb83b59e87934180968c73a15242008b2023-03-09T12:33:58ZengCambridge University PressEuropean Psychiatry0924-93381778-35852020-01-016310.1192/j.eurpsy.2020.42Improving social function with real-world social-cognitive remediation in schizophrenia: Results from the RemedRugby quasi-experimental trialJulien Dubreucq0https://orcid.org/0000-0003-4079-4194Franck Gabayet1https://orcid.org/0000-0002-0585-0456Bernard Ycart2Megane Faraldo3https://orcid.org/0000-0002-2021-2049Fanny Melis4Thierry Lucas5Benjamin Arnaud6Mickael Bacconnier7Motassem Bakri8Gentiane Cambier9Florian Carmona10Isabelle Chereau11Titaua Challe12Sophie Morel13Sylvie Pires14Celine Roussel15Philippe Lamy16Guillaume Legrand17Emmanuelle Pages18Romain Pommier19Romain Rey20Yohan Souchet21Pierre-Michel Llorca22Catherine Massoubre23the RemedRugby GroupCentre de Neurosciences Cognitive, UMR 5229, CNRS and Université Lyon 1, Lyon, France Centre Référent de Réhabilitation Psychosociale et de Remédiation cognitive (C3R), Centre Hospitalier Alpes Isère, Grenoble, France Fondation FondaMental, Créteil, France Réseau Handicap Psychique, Grenoble, FranceCentre Référent de Réhabilitation Psychosociale et de Remédiation cognitive (C3R), Centre Hospitalier Alpes Isère, Grenoble, France Fondation FondaMental, Créteil, FranceLaboratoire Jean Kuntzmann, CNRS UMR 5224, Université Grenoble-Alpes, Grenoble, FranceCentre Référent de Réhabilitation Psychosociale et de Remédiation cognitive (C3R), Centre Hospitalier Alpes Isère, Grenoble, France Fondation FondaMental, Créteil, FranceCentre Référent de Réhabilitation Psychosociale et de Remédiation cognitive (C3R), Centre Hospitalier Alpes Isère, Grenoble, FranceCentre Référent de Réhabilitation Psychosociale et de Remédiation cognitive (C3R), Centre Hospitalier Alpes Isère, Grenoble, FranceCentre Hospitalier Sainte Marie de Clermont Ferrand, 33 rue Gabriel Péri, CS 9912, Clermont-Ferrand Cedex 1 63037, FranceCentre Médical La Teppe, 25 Avenue de la Bouterne, CS 9721, Tain-l'Hermitage Cedex 26602, France Centre de Réhabilitation Psychosociale et de Remédiation Cognitive (C2R), CH Drôme Vivarais, Montéléger, FranceCentre de Réhabilitation Psychosociale et de Remédiation Cognitive (C2R), CH Drôme Vivarais, Montéléger, FranceCentre Hospitalier de la Savoie, 89 avenue de Bassens, Bassens73000, FranceREHALise, CHU de Saint-Etienne, Saint-Etienne, FranceFondation FondaMental, Créteil, France CMP B, CHU, EA 7280 Faculté de Médecine, Université d'Auvergne, BP 69, Clermont-Ferrand Cedex 1 63003, FranceCentre Départemental de Réhabilitation Psychosociale des Glières, 219 Chemin des Bois des Fornets, La Roche sur Foron 74800, FranceCentre de Réhabilitation Psychosociale et de Remédiation Cognitive (C2R), CH Drôme Vivarais, Montéléger, FranceFondation FondaMental, Créteil, France CMP B, CHU, EA 7280 Faculté de Médecine, Université d'Auvergne, BP 69, Clermont-Ferrand Cedex 1 63003, FranceCentre Départemental de Réhabilitation Psychosociale des Glières, 219 Chemin des Bois des Fornets, La Roche sur Foron 74800, FranceREHALise, CHU de Saint-Etienne, Saint-Etienne, FranceCentre Hospitalier Sainte Marie de Clermont Ferrand, 33 rue Gabriel Péri, CS 9912, Clermont-Ferrand Cedex 1 63037, FranceCentre Hospitalier de la Savoie, 89 avenue de Bassens, Bassens73000, FranceREHALise, CHU de Saint-Etienne, Saint-Etienne, FranceFondation FondaMental, Créteil, France Université Claude Bernard Lyon 1/Centre Hospitalier Le Vinatier Pole Est BP 300 39, 95 bd Pinel, Bron Cedex69678, FranceFondation FondaMental, Créteil, France Université Claude Bernard Lyon 1/Centre Hospitalier Le Vinatier Pole Est BP 300 39, 95 bd Pinel, Bron Cedex69678, FranceFondation FondaMental, Créteil, France CMP B, CHU, EA 7280 Faculté de Médecine, Université d'Auvergne, BP 69, Clermont-Ferrand Cedex 1 63003, FranceREHALise, CHU de Saint-Etienne, Saint-Etienne, FranceAbstractBackground.Functional capacity (FC) has been identified as a key outcome to improve real-world functioning in schizophrenia. FC is influenced by cognitive impairments, negative symptoms, self-stigma and reduced physical activity (PA). Psychosocial interventions targeting FC are still under-developed.Methods.we conducted a quasi-experimental study evaluating the effects of an exercise-enriched integrated social cognitive remediation (SCR) intervention (RemedRugby [RR]) compared with an active control group practicing Touch Rugby (TR). To our knowledge, this is the first trial to date evaluating the effectiveness of such a program provided in a real-life environment.Results.Eighty-seven people with schizophrenia were included and allocated to either the RR group (n = 57) or the TR group (n = 30) according to the routine clinical practice of the recruiting center. Outcomes were evaluated at baseline and post-treatment in both groups and after 6 months of follow-up in the RR group using standardized scales for symptom severity, social functioning, self-stigma, and a large cognitive battery. After treatment we observed moderate to large improvements in social function (Personal and Social Performance Scale [PSP], p < 0.001, d = 1.255), symptom severity (Positive and Negative Syndrome Scale [PANSS] negative, p < 0.001, d = 0.827; PANSS GP, p < 0.001, d = 0.991; PANSS positive, p = 0.009, d = 0.594), verbal abstraction (p = 0.008, d = 0.554), aggression bias (p = 0.008, d = 0.627), and self-stigma (stereotype endorsement, p = 0.019, d = 0.495; discrimination experiences, p = 0.047; d = 0.389) that were specific to the RR group and were not observed in participants playing only TR. Effects were persistent over time and even larger between post-treatment and follow-up.Conclusions.Exercise-enriched integrated SCR appears promising to improve real-life functioning in schizophrenia. Future research should investigate the potential effects of this intervention on neuroplasticity and physical fitness.https://www.cambridge.org/core/product/identifier/S0924933820000425/type/journal_articlePhysical activityschizophreniasocial cognitive remediationsocial functiontouchrugby |
| spellingShingle | Julien Dubreucq Franck Gabayet Bernard Ycart Megane Faraldo Fanny Melis Thierry Lucas Benjamin Arnaud Mickael Bacconnier Motassem Bakri Gentiane Cambier Florian Carmona Isabelle Chereau Titaua Challe Sophie Morel Sylvie Pires Celine Roussel Philippe Lamy Guillaume Legrand Emmanuelle Pages Romain Pommier Romain Rey Yohan Souchet Pierre-Michel Llorca Catherine Massoubre the RemedRugby Group Improving social function with real-world social-cognitive remediation in schizophrenia: Results from the RemedRugby quasi-experimental trial European Psychiatry Physical activity schizophrenia social cognitive remediation social function touchrugby |
| title | Improving social function with real-world social-cognitive remediation in schizophrenia: Results from the RemedRugby quasi-experimental trial |
| title_full | Improving social function with real-world social-cognitive remediation in schizophrenia: Results from the RemedRugby quasi-experimental trial |
| title_fullStr | Improving social function with real-world social-cognitive remediation in schizophrenia: Results from the RemedRugby quasi-experimental trial |
| title_full_unstemmed | Improving social function with real-world social-cognitive remediation in schizophrenia: Results from the RemedRugby quasi-experimental trial |
| title_short | Improving social function with real-world social-cognitive remediation in schizophrenia: Results from the RemedRugby quasi-experimental trial |
| title_sort | improving social function with real world social cognitive remediation in schizophrenia results from the remedrugby quasi experimental trial |
| topic | Physical activity schizophrenia social cognitive remediation social function touchrugby |
| url | https://www.cambridge.org/core/product/identifier/S0924933820000425/type/journal_article |
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