Prevalence of Glucose-6-phosphate dehydrogenase (G6PD) deficiency of newborns in Rasol Akram and Ali Asghar hospitals of Tehran
Background: Glucose 6- phosphate dehydrogenase (G6PD) deficiency is a genetic disorder and assessment of newborns with or without this deficiency is counted as one of the effective components in public health evaluation in different countries. So, this study was aimed to assess prevalence of G6PD de...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Bushehr University of Medical Sciences
2013-04-01
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| Series: | Iranian South Medical Journal |
| Subjects: | |
| Online Access: | http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-313&slc_lang=en&sid=1 |
| _version_ | 1828471759329820672 |
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| author | Ali Kazemi Hossein Norouzi Mahmood Tohidi Moghaddam Alireza Naderloo |
| author_facet | Ali Kazemi Hossein Norouzi Mahmood Tohidi Moghaddam Alireza Naderloo |
| author_sort | Ali Kazemi |
| collection | DOAJ |
| description | Background: Glucose 6- phosphate dehydrogenase (G6PD) deficiency is a genetic disorder and assessment of newborns with or without this deficiency is counted as one of the effective components in public health evaluation in different countries. So, this study was aimed to assess prevalence of G6PD deficiency in newborns in Tehran. Material and Methods: This cross- sectional study was done on 1226 newborns (585 male, 641 female) in Rasol Akram and Ali Asghar hospitals in 2009. G6PD screening was done by fluorescent spot test method and G6PD activity was determined by Beutler method. Indices of weight, age, bilirubin level, blood group, and coomb’s test and reticulocyte count were recorded for all neonates. Obtained results were assessed using SPSS program (version 16) and T student and Chi square tests and (P<0.05) was considered significant. Results: Of 1226 newborns, 27 newborns (2/2 %) (12 male, 15 female) were G6PD deficient which of 27 neonates, 19 neonates had hyperbilirubinaemia. G6PD activity was 11/4±1.1 (U/gHb) in normal newborns but in G6PD deficient newborns was 2.2±0.63 (U/gHb) which difference between them was significant. (P=0.027) The mean value of bilirubin was 7.7±0.11 (mg/dL) in normal neonates but in deficient was 13.1±1.1 (mg/dL) which was statistically higher than normal newborns (P =0.047). Of total newborns transfusion exchange was done for 22 newborns which 8 neonates (36.3 %) of them were G6PD deficient. Conclusion: With regard to prevalence of 2.2 % of G6PD deficiency, necessity of cord blood samples’ assessment and training the high risk mothers for prevention of hyperbilirubinaemia induced neurologic damage (kernicterus) are recommended. |
| first_indexed | 2024-12-11T05:17:13Z |
| format | Article |
| id | doaj.art-cb8620349f7347c48d2fa3469644696f |
| institution | Directory Open Access Journal |
| issn | 1735-4374 1735-6954 |
| language | English |
| last_indexed | 2024-12-11T05:17:13Z |
| publishDate | 2013-04-01 |
| publisher | Bushehr University of Medical Sciences |
| record_format | Article |
| series | Iranian South Medical Journal |
| spelling | doaj.art-cb8620349f7347c48d2fa3469644696f2022-12-22T01:19:47ZengBushehr University of Medical SciencesIranian South Medical Journal1735-43741735-69542013-04-011616168Prevalence of Glucose-6-phosphate dehydrogenase (G6PD) deficiency of newborns in Rasol Akram and Ali Asghar hospitals of TehranAli Kazemi0Hossein Norouzi1Mahmood Tohidi Moghaddam2Alireza Naderloo3 Department of Pharmacology, School of Specialized Sciences, Science and Research branch, Islamic Azad University, Tehran, IRAN Department of Laboratory Sciences, School of Allied medicine, Tehran University of Medical Sciences, Tehran, IRAN Department of Nutrition, School of Medicine, Tehran University of Medical Sciences, Tehran, IRAN Department of Computer Sciences, School of Allied medicine, Tehran University of Medical Sciences, Tehran, IRAN Background: Glucose 6- phosphate dehydrogenase (G6PD) deficiency is a genetic disorder and assessment of newborns with or without this deficiency is counted as one of the effective components in public health evaluation in different countries. So, this study was aimed to assess prevalence of G6PD deficiency in newborns in Tehran. Material and Methods: This cross- sectional study was done on 1226 newborns (585 male, 641 female) in Rasol Akram and Ali Asghar hospitals in 2009. G6PD screening was done by fluorescent spot test method and G6PD activity was determined by Beutler method. Indices of weight, age, bilirubin level, blood group, and coomb’s test and reticulocyte count were recorded for all neonates. Obtained results were assessed using SPSS program (version 16) and T student and Chi square tests and (P<0.05) was considered significant. Results: Of 1226 newborns, 27 newborns (2/2 %) (12 male, 15 female) were G6PD deficient which of 27 neonates, 19 neonates had hyperbilirubinaemia. G6PD activity was 11/4±1.1 (U/gHb) in normal newborns but in G6PD deficient newborns was 2.2±0.63 (U/gHb) which difference between them was significant. (P=0.027) The mean value of bilirubin was 7.7±0.11 (mg/dL) in normal neonates but in deficient was 13.1±1.1 (mg/dL) which was statistically higher than normal newborns (P =0.047). Of total newborns transfusion exchange was done for 22 newborns which 8 neonates (36.3 %) of them were G6PD deficient. Conclusion: With regard to prevalence of 2.2 % of G6PD deficiency, necessity of cord blood samples’ assessment and training the high risk mothers for prevention of hyperbilirubinaemia induced neurologic damage (kernicterus) are recommended.http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-313&slc_lang=en&sid=1Glucose -6 – phosphate dehydrogenase Hyperbilirubinemia newborns Iran |
| spellingShingle | Ali Kazemi Hossein Norouzi Mahmood Tohidi Moghaddam Alireza Naderloo Prevalence of Glucose-6-phosphate dehydrogenase (G6PD) deficiency of newborns in Rasol Akram and Ali Asghar hospitals of Tehran Iranian South Medical Journal Glucose -6 – phosphate dehydrogenase Hyperbilirubinemia newborns Iran |
| title | Prevalence of Glucose-6-phosphate dehydrogenase (G6PD) deficiency of newborns in Rasol Akram and Ali Asghar hospitals of Tehran |
| title_full | Prevalence of Glucose-6-phosphate dehydrogenase (G6PD) deficiency of newborns in Rasol Akram and Ali Asghar hospitals of Tehran |
| title_fullStr | Prevalence of Glucose-6-phosphate dehydrogenase (G6PD) deficiency of newborns in Rasol Akram and Ali Asghar hospitals of Tehran |
| title_full_unstemmed | Prevalence of Glucose-6-phosphate dehydrogenase (G6PD) deficiency of newborns in Rasol Akram and Ali Asghar hospitals of Tehran |
| title_short | Prevalence of Glucose-6-phosphate dehydrogenase (G6PD) deficiency of newborns in Rasol Akram and Ali Asghar hospitals of Tehran |
| title_sort | prevalence of glucose 6 phosphate dehydrogenase g6pd deficiency of newborns in rasol akram and ali asghar hospitals of tehran |
| topic | Glucose -6 – phosphate dehydrogenase Hyperbilirubinemia newborns Iran |
| url | http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-313&slc_lang=en&sid=1 |
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