Cytokine responses to SARS-COV2 infection in mother-infant dyads: a systematic review and meta-analysis
BackgroundThe COVID-19 pandemic has affected a significant number of pregnant women worldwide, but studies on immune responses have presented conflicting results. This study aims to systematically review cytokine profiles in pregnant women with SARS-CoV-2 infection and their infants to evaluate immu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1277697/full |
| _version_ | 1797658933081407488 |
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| author | Samhita Jain Isabel Elaine Allen Dongli Song Dongli Song Xianhua Piao Xianhua Piao Xianhua Piao |
| author_facet | Samhita Jain Isabel Elaine Allen Dongli Song Dongli Song Xianhua Piao Xianhua Piao Xianhua Piao |
| author_sort | Samhita Jain |
| collection | DOAJ |
| description | BackgroundThe COVID-19 pandemic has affected a significant number of pregnant women worldwide, but studies on immune responses have presented conflicting results. This study aims to systematically review cytokine profiles in pregnant women with SARS-CoV-2 infection and their infants to evaluate immune responses and potential transplacental transfer of cytokines.Materials and methodsA comprehensive search of 4 databases was conducted to identify relevant studies. Inclusion criteria included studies measuring individual cytokines in pregnant women and/or their neonates. Studies were evaluated for quality, and data were extracted for analysis. Meta-analyses were performed using the random-effects model.ResultsSeventeen studies met the inclusion criteria, including data from 748 pregnant women and 287 infants. More than three of these studies evaluated data of 20 cytokines in maternal serum, and data of 10 cytokines was available from cord blood samples. Only the serum level of CXCL10 was significantly up-regulated in SARS-CoV-2 positive pregnant women (n = 339) compared to SARS-CoV-2 negative pregnant women (n = 409). Subset analysis of maternal samples (n = 183) collected during the acute phase of COVID-19 infection showed elevated CXCL10 and IFN-γ. No significant differences in cytokine levels were found between cord blood samples collected from infants born to mothers with (n = 97) and without (n = 190) COVID-19 during gestation. Subset analysis of cord blood samples collected during the acute phase of maternal infection was limited by insufficient data. The heterogeneity among the studies was substantial.ConclusionThe findings suggest that maternal cytokines responses to SARS-CoV-2 infection during pregnancy are not significantly dysregulated, except for CXCL10 and IFN-γ during the acute phase of illness. No evidence of increased cytokine levels in cord blood samples was observed, although this could be impacted by the time period between initial maternal infection and cord blood collection. These results provide some reassurance to parents and healthcare providers but should be interpreted cautiously due to study variations and limitations. |
| first_indexed | 2024-03-11T18:06:35Z |
| format | Article |
| id | doaj.art-cb876628242d419f8f8696f521bfdff0 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-11T18:06:35Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-cb876628242d419f8f8696f521bfdff02023-10-17T07:30:01ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-10-011110.3389/fped.2023.12776971277697Cytokine responses to SARS-COV2 infection in mother-infant dyads: a systematic review and meta-analysisSamhita Jain0Isabel Elaine Allen1Dongli Song2Dongli Song3Xianhua Piao4Xianhua Piao5Xianhua Piao6Division of Neonatology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Pediatrics, Division of Neonatology, Santa Clara Valley Medical Center, San Jose, CA, United StatesDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, United StatesDivision of Neonatology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United StatesNewborn Brain Research Institute, University of California, San Francisco, San Francisco, CA, United StatesWeill Institute for Neuroscience, University of California, San Francisco, San Francisco CA, United StatesBackgroundThe COVID-19 pandemic has affected a significant number of pregnant women worldwide, but studies on immune responses have presented conflicting results. This study aims to systematically review cytokine profiles in pregnant women with SARS-CoV-2 infection and their infants to evaluate immune responses and potential transplacental transfer of cytokines.Materials and methodsA comprehensive search of 4 databases was conducted to identify relevant studies. Inclusion criteria included studies measuring individual cytokines in pregnant women and/or their neonates. Studies were evaluated for quality, and data were extracted for analysis. Meta-analyses were performed using the random-effects model.ResultsSeventeen studies met the inclusion criteria, including data from 748 pregnant women and 287 infants. More than three of these studies evaluated data of 20 cytokines in maternal serum, and data of 10 cytokines was available from cord blood samples. Only the serum level of CXCL10 was significantly up-regulated in SARS-CoV-2 positive pregnant women (n = 339) compared to SARS-CoV-2 negative pregnant women (n = 409). Subset analysis of maternal samples (n = 183) collected during the acute phase of COVID-19 infection showed elevated CXCL10 and IFN-γ. No significant differences in cytokine levels were found between cord blood samples collected from infants born to mothers with (n = 97) and without (n = 190) COVID-19 during gestation. Subset analysis of cord blood samples collected during the acute phase of maternal infection was limited by insufficient data. The heterogeneity among the studies was substantial.ConclusionThe findings suggest that maternal cytokines responses to SARS-CoV-2 infection during pregnancy are not significantly dysregulated, except for CXCL10 and IFN-γ during the acute phase of illness. No evidence of increased cytokine levels in cord blood samples was observed, although this could be impacted by the time period between initial maternal infection and cord blood collection. These results provide some reassurance to parents and healthcare providers but should be interpreted cautiously due to study variations and limitations.https://www.frontiersin.org/articles/10.3389/fped.2023.1277697/fullSARS-CoV2pregnancycytokinesmother-infant dyadcord blood |
| spellingShingle | Samhita Jain Isabel Elaine Allen Dongli Song Dongli Song Xianhua Piao Xianhua Piao Xianhua Piao Cytokine responses to SARS-COV2 infection in mother-infant dyads: a systematic review and meta-analysis Frontiers in Pediatrics SARS-CoV2 pregnancy cytokines mother-infant dyad cord blood |
| title | Cytokine responses to SARS-COV2 infection in mother-infant dyads: a systematic review and meta-analysis |
| title_full | Cytokine responses to SARS-COV2 infection in mother-infant dyads: a systematic review and meta-analysis |
| title_fullStr | Cytokine responses to SARS-COV2 infection in mother-infant dyads: a systematic review and meta-analysis |
| title_full_unstemmed | Cytokine responses to SARS-COV2 infection in mother-infant dyads: a systematic review and meta-analysis |
| title_short | Cytokine responses to SARS-COV2 infection in mother-infant dyads: a systematic review and meta-analysis |
| title_sort | cytokine responses to sars cov2 infection in mother infant dyads a systematic review and meta analysis |
| topic | SARS-CoV2 pregnancy cytokines mother-infant dyad cord blood |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1277697/full |
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