Imaging Cardiovascular Inflammation in the COVID-19 Era
Cardiac complications are among the most frequent extrapulmonary manifestations of COVID-19 and are associated with high mortality rates. Moreover, positive SARS-CoV-2 patients with underlying cardiovascular disease are more likely to require intensive care and are at higher risk of death. The under...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/6/1114 |
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| author | Andras Mester Imre Benedek Nora Rat Cosmin Tolescu Stefania Alexandra Polexa Theodora Benedek |
| author_facet | Andras Mester Imre Benedek Nora Rat Cosmin Tolescu Stefania Alexandra Polexa Theodora Benedek |
| author_sort | Andras Mester |
| collection | DOAJ |
| description | Cardiac complications are among the most frequent extrapulmonary manifestations of COVID-19 and are associated with high mortality rates. Moreover, positive SARS-CoV-2 patients with underlying cardiovascular disease are more likely to require intensive care and are at higher risk of death. The underlying mechanism for myocardial injury is multifaceted, in which the severe inflammatory response causes myocardial inflammation, coronary plaque destabilization, acute thrombotic events, and ischemia. Cardiac magnetic resonance (CMR) imaging is the non-invasive method of choice for identifying myocardial injury, and it is able to differentiate between underlying causes in various and often challenging clinical scenarios. Multimodal imaging protocols that incorporate CMR and computed tomography provide a complex evaluation for both respiratory and cardiovascular complications of SARS-CoV2 infection. This, in relation to biological evaluation of systemic inflammation, can guide appropriate therapeutic management in every stage of the disease. The use of artificial intelligence can further improve the diagnostic accuracy of these imaging techniques, thus enabling risk stratification and evaluation of prognosis. The present manuscript aims to review the current knowledge on the possible modalities for imaging COVID-related myocardial inflammation or post-COVID coronary inflammation and atherosclerosis. |
| first_indexed | 2024-03-10T10:17:57Z |
| format | Article |
| id | doaj.art-cb8857e7639f40e59d182b336f53e9d8 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T10:17:57Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-cb8857e7639f40e59d182b336f53e9d82023-11-22T00:43:17ZengMDPI AGDiagnostics2075-44182021-06-01116111410.3390/diagnostics11061114Imaging Cardiovascular Inflammation in the COVID-19 EraAndras Mester0Imre Benedek1Nora Rat2Cosmin Tolescu3Stefania Alexandra Polexa4Theodora Benedek5Department of Cardiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Târgu Mureș, RomaniaDepartment of Cardiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Târgu Mureș, RomaniaDepartment of Cardiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Târgu Mureș, RomaniaCardiology Clinic of the Emergency Clinical County Hospital of Târgu Mureș, 540142 Târgu Mureș, RomaniaCardiology Clinic of the Emergency Clinical County Hospital of Târgu Mureș, 540142 Târgu Mureș, RomaniaDepartment of Cardiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Târgu Mureș, RomaniaCardiac complications are among the most frequent extrapulmonary manifestations of COVID-19 and are associated with high mortality rates. Moreover, positive SARS-CoV-2 patients with underlying cardiovascular disease are more likely to require intensive care and are at higher risk of death. The underlying mechanism for myocardial injury is multifaceted, in which the severe inflammatory response causes myocardial inflammation, coronary plaque destabilization, acute thrombotic events, and ischemia. Cardiac magnetic resonance (CMR) imaging is the non-invasive method of choice for identifying myocardial injury, and it is able to differentiate between underlying causes in various and often challenging clinical scenarios. Multimodal imaging protocols that incorporate CMR and computed tomography provide a complex evaluation for both respiratory and cardiovascular complications of SARS-CoV2 infection. This, in relation to biological evaluation of systemic inflammation, can guide appropriate therapeutic management in every stage of the disease. The use of artificial intelligence can further improve the diagnostic accuracy of these imaging techniques, thus enabling risk stratification and evaluation of prognosis. The present manuscript aims to review the current knowledge on the possible modalities for imaging COVID-related myocardial inflammation or post-COVID coronary inflammation and atherosclerosis.https://www.mdpi.com/2075-4418/11/6/1114COVID-19cardiac magnetic resonanceinflammationmultimodal imagingmyocardial injuryartificial intelligence |
| spellingShingle | Andras Mester Imre Benedek Nora Rat Cosmin Tolescu Stefania Alexandra Polexa Theodora Benedek Imaging Cardiovascular Inflammation in the COVID-19 Era Diagnostics COVID-19 cardiac magnetic resonance inflammation multimodal imaging myocardial injury artificial intelligence |
| title | Imaging Cardiovascular Inflammation in the COVID-19 Era |
| title_full | Imaging Cardiovascular Inflammation in the COVID-19 Era |
| title_fullStr | Imaging Cardiovascular Inflammation in the COVID-19 Era |
| title_full_unstemmed | Imaging Cardiovascular Inflammation in the COVID-19 Era |
| title_short | Imaging Cardiovascular Inflammation in the COVID-19 Era |
| title_sort | imaging cardiovascular inflammation in the covid 19 era |
| topic | COVID-19 cardiac magnetic resonance inflammation multimodal imaging myocardial injury artificial intelligence |
| url | https://www.mdpi.com/2075-4418/11/6/1114 |
| work_keys_str_mv | AT andrasmester imagingcardiovascularinflammationinthecovid19era AT imrebenedek imagingcardiovascularinflammationinthecovid19era AT norarat imagingcardiovascularinflammationinthecovid19era AT cosmintolescu imagingcardiovascularinflammationinthecovid19era AT stefaniaalexandrapolexa imagingcardiovascularinflammationinthecovid19era AT theodorabenedek imagingcardiovascularinflammationinthecovid19era |