Nano-Graphene Oxide Functionalized Bioactive Poly(lactic acid) and Poly(ε-caprolactone) Nanofibrous Scaffolds
A versatile and convenient way to produce bioactive poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) electrospun nanofibrous scaffolds is described. PLA and PCL are extensively used as biocompatible scaffold materials for tissue engineering. Here, biobased nano graphene oxide dots (nGO) are in...
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MDPI AG
2018-04-01
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| Series: | Materials |
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| Online Access: | http://www.mdpi.com/1996-1944/11/4/566 |
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| author | Duo Wu Archana Samanta Rajiv K. Srivastava Minna Hakkarainen |
| author_facet | Duo Wu Archana Samanta Rajiv K. Srivastava Minna Hakkarainen |
| author_sort | Duo Wu |
| collection | DOAJ |
| description | A versatile and convenient way to produce bioactive poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) electrospun nanofibrous scaffolds is described. PLA and PCL are extensively used as biocompatible scaffold materials for tissue engineering. Here, biobased nano graphene oxide dots (nGO) are incorporated in PLA or PCL electrospun scaffolds during the electrospinning process aiming to enhance the mechanical properties and endorse osteo-bioactivity. nGO was found to tightly attach to the fibers through secondary interactions. It also improved the electrospinnability and fiber quality. The prepared nanofibrous scaffolds exhibited enhanced mechanical properties, increased hydrophilicity, good cytocompatibility and osteo-bioactivity. Therefore, immense potential for bone tissue engineering applications is anticipated. |
| first_indexed | 2024-04-13T05:37:00Z |
| format | Article |
| id | doaj.art-cb8a5496798f48639acbb138322c6d34 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-04-13T05:37:00Z |
| publishDate | 2018-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-cb8a5496798f48639acbb138322c6d342022-12-22T03:00:14ZengMDPI AGMaterials1996-19442018-04-0111456610.3390/ma11040566ma11040566Nano-Graphene Oxide Functionalized Bioactive Poly(lactic acid) and Poly(ε-caprolactone) Nanofibrous ScaffoldsDuo Wu0Archana Samanta1Rajiv K. Srivastava2Minna Hakkarainen3Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, SE-100 44 Stockholm, SwedenDepartment of Textile Technology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, IndiaDepartment of Textile Technology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, IndiaDepartment of Fibre and Polymer Technology, KTH Royal Institute of Technology, SE-100 44 Stockholm, SwedenA versatile and convenient way to produce bioactive poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) electrospun nanofibrous scaffolds is described. PLA and PCL are extensively used as biocompatible scaffold materials for tissue engineering. Here, biobased nano graphene oxide dots (nGO) are incorporated in PLA or PCL electrospun scaffolds during the electrospinning process aiming to enhance the mechanical properties and endorse osteo-bioactivity. nGO was found to tightly attach to the fibers through secondary interactions. It also improved the electrospinnability and fiber quality. The prepared nanofibrous scaffolds exhibited enhanced mechanical properties, increased hydrophilicity, good cytocompatibility and osteo-bioactivity. Therefore, immense potential for bone tissue engineering applications is anticipated.http://www.mdpi.com/1996-1944/11/4/566PLAPCLgraphene oxidescaffoldmechanical propertiesbiomineralization |
| spellingShingle | Duo Wu Archana Samanta Rajiv K. Srivastava Minna Hakkarainen Nano-Graphene Oxide Functionalized Bioactive Poly(lactic acid) and Poly(ε-caprolactone) Nanofibrous Scaffolds Materials PLA PCL graphene oxide scaffold mechanical properties biomineralization |
| title | Nano-Graphene Oxide Functionalized Bioactive Poly(lactic acid) and Poly(ε-caprolactone) Nanofibrous Scaffolds |
| title_full | Nano-Graphene Oxide Functionalized Bioactive Poly(lactic acid) and Poly(ε-caprolactone) Nanofibrous Scaffolds |
| title_fullStr | Nano-Graphene Oxide Functionalized Bioactive Poly(lactic acid) and Poly(ε-caprolactone) Nanofibrous Scaffolds |
| title_full_unstemmed | Nano-Graphene Oxide Functionalized Bioactive Poly(lactic acid) and Poly(ε-caprolactone) Nanofibrous Scaffolds |
| title_short | Nano-Graphene Oxide Functionalized Bioactive Poly(lactic acid) and Poly(ε-caprolactone) Nanofibrous Scaffolds |
| title_sort | nano graphene oxide functionalized bioactive poly lactic acid and poly ε caprolactone nanofibrous scaffolds |
| topic | PLA PCL graphene oxide scaffold mechanical properties biomineralization |
| url | http://www.mdpi.com/1996-1944/11/4/566 |
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