Personalized dietary advices provided by a dietitian increase calcium intake in outpatients with multiple sclerosis—Results from a randomized, controlled, single-blind trial
Background and aimsMultiple sclerosis (MS) is associated with osteoporosis, possibly due to neurological disability and decreased calcium intake. The objective of this study was to evaluate the efficacy of a personalized nutritional advice program by a dietitian compared to the delivery of a standar...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.919336/full |
| _version_ | 1828062584231690240 |
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| author | Sandrine Fiorella Sandrine Fiorella Hanane Agherbi Emilia El Houjeiry Giovanni Castelnovo Dimitri Renard Pauline Privat Elodie Santamaria Virginie Vallayer Sandrine Alonso Thierry Chevallier Candice Bancal Sabine Laurent-Chabalier Eric Thouvenot Eric Thouvenot |
| author_facet | Sandrine Fiorella Sandrine Fiorella Hanane Agherbi Emilia El Houjeiry Giovanni Castelnovo Dimitri Renard Pauline Privat Elodie Santamaria Virginie Vallayer Sandrine Alonso Thierry Chevallier Candice Bancal Sabine Laurent-Chabalier Eric Thouvenot Eric Thouvenot |
| author_sort | Sandrine Fiorella |
| collection | DOAJ |
| description | Background and aimsMultiple sclerosis (MS) is associated with osteoporosis, possibly due to neurological disability and decreased calcium intake. The objective of this study was to evaluate the efficacy of a personalized nutritional advice program by a dietitian compared to the delivery of a standard advice form to optimize dietary calcium intake in outpatients with MS.MethodsWe performed a randomized, controlled, parallel trial comparing the efficacy of a personalized dietary advice (PDA) program to standard advice form (SAF) to increase daily calcium intake in MS patients. The study population was composed by patients with relapsing-remitting MS aged 18–69 years old. PDA program consisted in dietary advice delivered by a dietitian at baseline, 1 month, and 3 months. Calcium and nutrient intake in patients from both groups was evaluated at baseline and 6 months using a dietary survey.ResultsOf the 194 patients screened for inclusion, 182 patients were included (79% female, median age of 42 years, and median EDSS of 2.0), and randomized to SAF (n = 92) or PDA (n = 90). At 6 months, median calcium intake increased by 241 mg/day in the PDA group and decreased by 120 mg/day in the SAF group (p < 0.0001). However, the median calcium intake was 947 mg/day in the SAF group and 778 mg/day in the PDA group at baseline (p = 0.0077), potentially favoring the effect of dietary advice. Complementary analyses focusing on patients with insufficient calcium intakes at baseline revealed comparable values in both groups (p = 0.69). Of those, patients included in the PDA group obtained significantly higher calcium intakes at 6 months than patients from the SAF group (p = 0.0086) independently of EDSS, PASAT, HADS and EQ-5D scores.ConclusionThis work shows the efficacy of dietary management based on personalized advice program over 3 months to durably increase calcium consumption in MS patients with insufficient calcium intake.Clinical trial registrationclinicaltrials.gov, identifier NCT02664623. |
| first_indexed | 2024-04-10T22:31:06Z |
| format | Article |
| id | doaj.art-cb8d237915e045ba99ec42c333564096 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-10T22:31:06Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-cb8d237915e045ba99ec42c3335640962023-01-17T05:57:30ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-01-01910.3389/fnut.2022.919336919336Personalized dietary advices provided by a dietitian increase calcium intake in outpatients with multiple sclerosis—Results from a randomized, controlled, single-blind trialSandrine Fiorella0Sandrine Fiorella1Hanane Agherbi2Emilia El Houjeiry3Giovanni Castelnovo4Dimitri Renard5Pauline Privat6Elodie Santamaria7Virginie Vallayer8Sandrine Alonso9Thierry Chevallier10Candice Bancal11Sabine Laurent-Chabalier12Eric Thouvenot13Eric Thouvenot14Department of Neurology, CHU Nîmes, University of Montpellier, Montpellier, FranceUnité Transversale de Nutrition Clinique, CHU Nîmes, University of Montpellier, Montpellier, FranceDepartment of Neurology, CHU Nîmes, University of Montpellier, Montpellier, FranceDepartment of Neurology, CHU Nîmes, University of Montpellier, Montpellier, FranceDepartment of Neurology, CHU Nîmes, University of Montpellier, Montpellier, FranceDepartment of Neurology, CHU Nîmes, University of Montpellier, Montpellier, FranceUnité Transversale de Nutrition Clinique, CHU Nîmes, University of Montpellier, Montpellier, FranceUnité Transversale de Nutrition Clinique, CHU Nîmes, University of Montpellier, Montpellier, FranceUnité Transversale de Nutrition Clinique, CHU Nîmes, University of Montpellier, Montpellier, FranceDepartment of Biostatistics, Clinical Epidemiology, Public Health and Innovation in Methodology, CHU Nîmes, University of Montpellier, Montpellier, FranceDepartment of Biostatistics, Clinical Epidemiology, Public Health and Innovation in Methodology, CHU Nîmes, University of Montpellier, Montpellier, FranceLaboratory of Biochemistry and Molecular Biology, CHU Nîmes, University of Montpellier, Montpellier, FranceDepartment of Biostatistics, Clinical Epidemiology, Public Health and Innovation in Methodology, CHU Nîmes, University of Montpellier, Montpellier, FranceDepartment of Neurology, CHU Nîmes, University of Montpellier, Montpellier, FranceThe Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, FranceBackground and aimsMultiple sclerosis (MS) is associated with osteoporosis, possibly due to neurological disability and decreased calcium intake. The objective of this study was to evaluate the efficacy of a personalized nutritional advice program by a dietitian compared to the delivery of a standard advice form to optimize dietary calcium intake in outpatients with MS.MethodsWe performed a randomized, controlled, parallel trial comparing the efficacy of a personalized dietary advice (PDA) program to standard advice form (SAF) to increase daily calcium intake in MS patients. The study population was composed by patients with relapsing-remitting MS aged 18–69 years old. PDA program consisted in dietary advice delivered by a dietitian at baseline, 1 month, and 3 months. Calcium and nutrient intake in patients from both groups was evaluated at baseline and 6 months using a dietary survey.ResultsOf the 194 patients screened for inclusion, 182 patients were included (79% female, median age of 42 years, and median EDSS of 2.0), and randomized to SAF (n = 92) or PDA (n = 90). At 6 months, median calcium intake increased by 241 mg/day in the PDA group and decreased by 120 mg/day in the SAF group (p < 0.0001). However, the median calcium intake was 947 mg/day in the SAF group and 778 mg/day in the PDA group at baseline (p = 0.0077), potentially favoring the effect of dietary advice. Complementary analyses focusing on patients with insufficient calcium intakes at baseline revealed comparable values in both groups (p = 0.69). Of those, patients included in the PDA group obtained significantly higher calcium intakes at 6 months than patients from the SAF group (p = 0.0086) independently of EDSS, PASAT, HADS and EQ-5D scores.ConclusionThis work shows the efficacy of dietary management based on personalized advice program over 3 months to durably increase calcium consumption in MS patients with insufficient calcium intake.Clinical trial registrationclinicaltrials.gov, identifier NCT02664623.https://www.frontiersin.org/articles/10.3389/fnut.2022.919336/fullcalcium intakedietary advicemultiple sclerosiscoaching/accompanimentpersonalized medicine |
| spellingShingle | Sandrine Fiorella Sandrine Fiorella Hanane Agherbi Emilia El Houjeiry Giovanni Castelnovo Dimitri Renard Pauline Privat Elodie Santamaria Virginie Vallayer Sandrine Alonso Thierry Chevallier Candice Bancal Sabine Laurent-Chabalier Eric Thouvenot Eric Thouvenot Personalized dietary advices provided by a dietitian increase calcium intake in outpatients with multiple sclerosis—Results from a randomized, controlled, single-blind trial Frontiers in Nutrition calcium intake dietary advice multiple sclerosis coaching/accompaniment personalized medicine |
| title | Personalized dietary advices provided by a dietitian increase calcium intake in outpatients with multiple sclerosis—Results from a randomized, controlled, single-blind trial |
| title_full | Personalized dietary advices provided by a dietitian increase calcium intake in outpatients with multiple sclerosis—Results from a randomized, controlled, single-blind trial |
| title_fullStr | Personalized dietary advices provided by a dietitian increase calcium intake in outpatients with multiple sclerosis—Results from a randomized, controlled, single-blind trial |
| title_full_unstemmed | Personalized dietary advices provided by a dietitian increase calcium intake in outpatients with multiple sclerosis—Results from a randomized, controlled, single-blind trial |
| title_short | Personalized dietary advices provided by a dietitian increase calcium intake in outpatients with multiple sclerosis—Results from a randomized, controlled, single-blind trial |
| title_sort | personalized dietary advices provided by a dietitian increase calcium intake in outpatients with multiple sclerosis results from a randomized controlled single blind trial |
| topic | calcium intake dietary advice multiple sclerosis coaching/accompaniment personalized medicine |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.919336/full |
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