Effect of Interval and Continued Exercises with Crocin on Bax/Bcl-2 in Diabetic Obese Rats
Objective: Diabetes is a metabolic disease which is linked to increased physical disabilities and muscle tissue damage. The aim of this study was to investigate the effect of interval and continued exercises with crocin on Bax/Bcl-2 ratio in diabetic obese rats. Materials and Methods: In this clinic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences
2019-09-01
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| Series: | Iranian Journal of Diabetes and Obesity |
| Subjects: | |
| Online Access: | http://ijdo.ssu.ac.ir/article-1-515-en.html |
| _version_ | 1818677180716023808 |
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| author | Ghobad Hassanpour Hojatollah Nikbakht Mohammad ali Azarbayjani Nader Shakeri Hossein Abed Natanzi |
| author_facet | Ghobad Hassanpour Hojatollah Nikbakht Mohammad ali Azarbayjani Nader Shakeri Hossein Abed Natanzi |
| author_sort | Ghobad Hassanpour |
| collection | DOAJ |
| description | Objective: Diabetes is a metabolic disease which is linked to increased physical disabilities and muscle tissue damage. The aim of this study was to investigate the effect of interval and continued exercises with crocin on Bax/Bcl-2 ratio in diabetic obese rats.
Materials and Methods: In this clinical trial study, 56 adult diabetic rats (high-fat diet and venous injection of streptozotocin) were selected and randomly assigned to groups (1), intense interval exercises (2), low intensity exercise (3), intense interval exercise with crocin consumption, (4) Low intensity exercise with crocin consumption, (5) Crocin consumption, (6) sham and (7) control were divided. Intense interval and low intensity exercise groups lasted for 8 weeks, three sessions per week, with intensity of 80 to 85 and 50 to 55 percent of maximum treadmill running, and crocin consumption groups for 8 weeks per day, mg / kg 25 crocin were taken peritoneal. To analyze the research hypotheses, Kolmogorov- Smirnov tests, independent T- tests and two-way multi-variable analysis of variance were used along with Benferron's comparison method. It should be noted that the significance level in all measurements was considered to be P-value≤ 0.05.
Results: Results showed that exercise (P-value: 0.12) and crocin (P-value: 0.10) consumption had no significant effect on Bax/Bcl-2 gene expression in diabetic rats. Also interaction of exercise and crocin consumption on Bax/Bcl-2 was not significant (P-value: 0.12).
Conclusion: It appears that exercise and crocin consumption have not interaction effect on improvement of Bax / Bcl-2 ratio in diabetic rats. |
| first_indexed | 2024-12-17T08:55:17Z |
| format | Article |
| id | doaj.art-cb8d8f39d3f747428a8c2d7dfb42266f |
| institution | Directory Open Access Journal |
| issn | 2008-6792 2345-2250 |
| language | English |
| last_indexed | 2024-12-17T08:55:17Z |
| publishDate | 2019-09-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Diabetes and Obesity |
| spelling | doaj.art-cb8d8f39d3f747428a8c2d7dfb42266f2022-12-21T21:55:59ZengShahid Sadoughi University of Medical SciencesIranian Journal of Diabetes and Obesity2008-67922345-22502019-09-01113196199Effect of Interval and Continued Exercises with Crocin on Bax/Bcl-2 in Diabetic Obese RatsGhobad Hassanpour0Hojatollah Nikbakht1Mohammad ali Azarbayjani2Nader Shakeri3Hossein Abed Natanzi4 Department of Exercise Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran Department of Exercise Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran Department of Exercise Physiology, Science and Research Branch, Islamic AzadUniversity, Tehran, Iran Department of Exercise Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran Objective: Diabetes is a metabolic disease which is linked to increased physical disabilities and muscle tissue damage. The aim of this study was to investigate the effect of interval and continued exercises with crocin on Bax/Bcl-2 ratio in diabetic obese rats. Materials and Methods: In this clinical trial study, 56 adult diabetic rats (high-fat diet and venous injection of streptozotocin) were selected and randomly assigned to groups (1), intense interval exercises (2), low intensity exercise (3), intense interval exercise with crocin consumption, (4) Low intensity exercise with crocin consumption, (5) Crocin consumption, (6) sham and (7) control were divided. Intense interval and low intensity exercise groups lasted for 8 weeks, three sessions per week, with intensity of 80 to 85 and 50 to 55 percent of maximum treadmill running, and crocin consumption groups for 8 weeks per day, mg / kg 25 crocin were taken peritoneal. To analyze the research hypotheses, Kolmogorov- Smirnov tests, independent T- tests and two-way multi-variable analysis of variance were used along with Benferron's comparison method. It should be noted that the significance level in all measurements was considered to be P-value≤ 0.05. Results: Results showed that exercise (P-value: 0.12) and crocin (P-value: 0.10) consumption had no significant effect on Bax/Bcl-2 gene expression in diabetic rats. Also interaction of exercise and crocin consumption on Bax/Bcl-2 was not significant (P-value: 0.12). Conclusion: It appears that exercise and crocin consumption have not interaction effect on improvement of Bax / Bcl-2 ratio in diabetic rats.http://ijdo.ssu.ac.ir/article-1-515-en.htmldiabetesbax/bcl2exercisescrocin |
| spellingShingle | Ghobad Hassanpour Hojatollah Nikbakht Mohammad ali Azarbayjani Nader Shakeri Hossein Abed Natanzi Effect of Interval and Continued Exercises with Crocin on Bax/Bcl-2 in Diabetic Obese Rats Iranian Journal of Diabetes and Obesity diabetes bax/bcl2 exercises crocin |
| title | Effect of Interval and Continued Exercises with Crocin on Bax/Bcl-2 in Diabetic Obese Rats |
| title_full | Effect of Interval and Continued Exercises with Crocin on Bax/Bcl-2 in Diabetic Obese Rats |
| title_fullStr | Effect of Interval and Continued Exercises with Crocin on Bax/Bcl-2 in Diabetic Obese Rats |
| title_full_unstemmed | Effect of Interval and Continued Exercises with Crocin on Bax/Bcl-2 in Diabetic Obese Rats |
| title_short | Effect of Interval and Continued Exercises with Crocin on Bax/Bcl-2 in Diabetic Obese Rats |
| title_sort | effect of interval and continued exercises with crocin on bax bcl 2 in diabetic obese rats |
| topic | diabetes bax/bcl2 exercises crocin |
| url | http://ijdo.ssu.ac.ir/article-1-515-en.html |
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