Lipocalin-2 Deficiency Reduces Oxidative Stress and Neuroinflammation and Results in Attenuation of Kainic Acid-Induced Hippocampal Cell Death

Lipocalin-2 Deficiency Reduces Oxidative Stress and Neuroinflammation and Results in Attenuation of Kainic Acid-Induced Hippocampal Cell Death

The hippocampal cell death that follows kainic acid (KA)-induced seizures is associated with blood–brain barrier (BBB) leakage and oxidative stress. Lipocalin-2 (LCN2) is an iron-trafficking protein which contributes to both oxidative stress and inflammation. However, LCN2′s role in KA-induced hippo...

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Bibliographic Details
Main Authors: Hyun Joo Shin, Eun Ae Jeong, Jong Youl Lee, Hyeong Seok An, Hye Min Jang, Yu Jeong Ahn, Jaewoong Lee, Kyung Eun Kim, Gu Seob Roh
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Antioxidants
Subjects:
kainic acid
lipocalin-2
oxidative stress
neuroinflammation
hippocampus
Online Access:https://www.mdpi.com/2076-3921/10/1/100

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