History of mild traumatic brain injury is associated with deficits in relational memory, reduced hippocampal volume, and less neural activity later in life
Evidence suggests that a history of head trauma is associated with memory deficits later in life. The majority of previous research has focused on moderate-to-severe traumatic brain injury (TBI), but recent evidence suggests that even a mild TBI (mTBI) can interact with the aging process and produce...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00041/full |
| _version_ | 1818989925159141376 |
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| author | Jim M Monti Jim M Monti Michelle W Voss Ari ePence Edward eMcAuley Edward eMcAuley Arthur F Kramer Arthur F Kramer Arthur F Kramer Neal J Cohen Neal J Cohen Neal J Cohen |
| author_facet | Jim M Monti Jim M Monti Michelle W Voss Ari ePence Edward eMcAuley Edward eMcAuley Arthur F Kramer Arthur F Kramer Arthur F Kramer Neal J Cohen Neal J Cohen Neal J Cohen |
| author_sort | Jim M Monti |
| collection | DOAJ |
| description | Evidence suggests that a history of head trauma is associated with memory deficits later in life. The majority of previous research has focused on moderate-to-severe traumatic brain injury (TBI), but recent evidence suggests that even a mild TBI (mTBI) can interact with the aging process and produce reductions in memory performance. This study examined the association of mTBI with memory and the brain by comparing young and middle-aged adults who have had mTBI in their recent (several years ago) and remote (several decades ago) past, respectively, with control subjects on a face-scene relational memory paradigm while they underwent functional magnetic resonance imaging. Hippocampal volumes were also examined from high-resolution structural images. Results indicated middle-aged adults with a head injury in their remote past had impaired memory compared to gender, age, and education matched control participants, consistent with previous results in the study of memory, aging, and TBI. The present findings extended previous results by demonstrating that these individuals also had smaller bilateral hippocampi, and had reduced neural activity during memory performance in cortical regions important for memory retrieval. These results indicate that a history of mTBI may be one of the many factors that negatively influence cognitive and brain health in aging. |
| first_indexed | 2024-12-20T19:46:13Z |
| format | Article |
| id | doaj.art-cb8f09a069f246ab94e58409ecf03dec |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-20T19:46:13Z |
| publishDate | 2013-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-cb8f09a069f246ab94e58409ecf03dec2022-12-21T19:28:24ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652013-08-01510.3389/fnagi.2013.0004160091History of mild traumatic brain injury is associated with deficits in relational memory, reduced hippocampal volume, and less neural activity later in lifeJim M Monti0Jim M Monti1Michelle W Voss2Ari ePence3Edward eMcAuley4Edward eMcAuley5Arthur F Kramer6Arthur F Kramer7Arthur F Kramer8Neal J Cohen9Neal J Cohen10Neal J Cohen11University of Illinois Urbana-ChampaignUniversity of Illinois Urbana ChampaignUniversity of IowaUniversity of Illinois Urbana ChampaignUniversity of Illinois Urbana-ChampaignUniversity of Illinois Urbana ChampaignUniversity of Illinois Urbana ChampaignUniversity of Illinois Urbana-ChampaignUniversity of Illinois Urbana-ChampaignUniversity of Illinois Urbana ChampaignUniversity of Illinois Urbana-ChampaignUniversity of Illinois Urbana-ChampaignEvidence suggests that a history of head trauma is associated with memory deficits later in life. The majority of previous research has focused on moderate-to-severe traumatic brain injury (TBI), but recent evidence suggests that even a mild TBI (mTBI) can interact with the aging process and produce reductions in memory performance. This study examined the association of mTBI with memory and the brain by comparing young and middle-aged adults who have had mTBI in their recent (several years ago) and remote (several decades ago) past, respectively, with control subjects on a face-scene relational memory paradigm while they underwent functional magnetic resonance imaging. Hippocampal volumes were also examined from high-resolution structural images. Results indicated middle-aged adults with a head injury in their remote past had impaired memory compared to gender, age, and education matched control participants, consistent with previous results in the study of memory, aging, and TBI. The present findings extended previous results by demonstrating that these individuals also had smaller bilateral hippocampi, and had reduced neural activity during memory performance in cortical regions important for memory retrieval. These results indicate that a history of mTBI may be one of the many factors that negatively influence cognitive and brain health in aging.http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00041/fullAgingHippocampusfMRIMTBIrelational memory |
| spellingShingle | Jim M Monti Jim M Monti Michelle W Voss Ari ePence Edward eMcAuley Edward eMcAuley Arthur F Kramer Arthur F Kramer Arthur F Kramer Neal J Cohen Neal J Cohen Neal J Cohen History of mild traumatic brain injury is associated with deficits in relational memory, reduced hippocampal volume, and less neural activity later in life Frontiers in Aging Neuroscience Aging Hippocampus fMRI MTBI relational memory |
| title | History of mild traumatic brain injury is associated with deficits in relational memory, reduced hippocampal volume, and less neural activity later in life |
| title_full | History of mild traumatic brain injury is associated with deficits in relational memory, reduced hippocampal volume, and less neural activity later in life |
| title_fullStr | History of mild traumatic brain injury is associated with deficits in relational memory, reduced hippocampal volume, and less neural activity later in life |
| title_full_unstemmed | History of mild traumatic brain injury is associated with deficits in relational memory, reduced hippocampal volume, and less neural activity later in life |
| title_short | History of mild traumatic brain injury is associated with deficits in relational memory, reduced hippocampal volume, and less neural activity later in life |
| title_sort | history of mild traumatic brain injury is associated with deficits in relational memory reduced hippocampal volume and less neural activity later in life |
| topic | Aging Hippocampus fMRI MTBI relational memory |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00041/full |
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